Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil

Williamson, Joseph R.; Chang, Katherine; Rowold, Edwin; Marvel, Joyce; Tomlinson, Martha Scott; Sherman, William R.; Ackermann, Karen; Kilo, Charles

doi:10.1016/0026-0495(86)90186-1

Cited by 28 publications

(19 citation statements)

References 32 publications

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“…The increases in granulation tissue polyol levels and 125 Ialbumin permeation of granulation tissue vessels, as well as the decreased plasma levels of IGF-I, in sham-operated diabetic rats (vs. sham-operated nondiabetic rats) are consistent with previous observations in this animal model (20)(21)(22)(23)(24)28). The finding that granulation tissue polyol levels fell dramatically in 2-day insulin-pump diabetic rats and did not differ significantly from those of 2-day sham-operated control rats is consistent with the normalization of plasma glucose levels in these rats as well as with numerous reports demonstrating that the polyol content of cells and tissues is related to ambient glucose levels in vivo and that polyol levels increase during incubation of cells and tissues in vitro in media containing high concentrations of glucose (14)(15)(16)(35)(36)(37).…”

Section: Discussionsupporting

confidence: 90%

“…Because TMS sorbitol does not separate from TMS dulcitol or TMS mannitol, we have reported all levels as polyol. Details of these techniques are described in previous publications (21,22). Statistics.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, increased polyol metabolism in diabetic animals has also been linked to the development of morphological (17)(18)(19) and functional (20)(21)(22)(23)(24)(25) changes in the microvasculature. The effect of rapid normalization of glycemia on polyol metabolism and vascular function in diabetic rats is unknown.…”

mentioning

confidence: 99%

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Effect of Rapid Normalization of Plasma Glucose Levels on Microvascular Dysfunction and Polyol Metabolism in Diabetic Rats

et al. 1988

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Effects of rapid normalization of plasma glucose levels (by insulin infused via Alzet pumps implanted intraperitoneally) on plasma insulin-like growth factor I (IGF-I) levels, granulation tissue polyol levels, and vascular permeation by 125I-labeled albumin were examined in male Sprague-Dawley rats with streptozocin-induced (60-65 mg/kg) diabetes. Two days after implantation of pumps, plasma insulin levels were twice normal levels and remained elevated (1.4-2.5 times normal) throughout the remainder of the study. Plasma glucose levels and granulation tissue polyol levels were normalized within 2 days after initiation of insulin treatment. Plasma IGF-I levels were significantly increased (2 times) by 2 days, but were not normalized until 7 days. In contrast, 125I-albumin permeation normalized at a much slower relatively linear rate and was still not completely normal after 14 days of insulin treatment. In view of 1) previous studies demonstrating that diabetes-induced increases in 125I-albumin permeation in this tissue are linked to increased metabolism of glucose to sorbitol and 2) the rapid normalization of tissue polyol levels in this study, the relatively linear rate of normalization of vascular permeability over 14 days in these studies suggests that impaired vascular barrier functional integrity in this model is mediated by structural and/or functional vascular alterations associated with sustained increased polyol metabolism rather than by increased polyol levels per se and/or by readily reversible functional and metabolic alterations associated with acute increases in polyol metabolism.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

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Effect of Rapid Normalization of Plasma Glucose Levels on Microvascular Dysfunction and Polyol Metabolism in Diabetic Rats

et al. 1988

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“…Williams et al report that sorbinil markedly diminishes the increase in 125 I-albumin permeation of new vessels formed after onset of diabetes without the need to normalize blood glucose levels. 155 Vessels formed prior to diabetic insult do not show pathological increases in permeability. 155 …”

Section: Aldose Reductase Inhibitionmentioning

confidence: 97%

Abnormal angiogenesis in diabetes mellitus

Martin

Komada

Sane

2002

Medicinal Research Reviews

409

274

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The adverse long-term effects of diabetes mellitus have been well described and involve many organ systems. While diabetes management has largely focused on control of hyperglycemia, the presence of abnormalities of angiogenesis may cause or contribute to many of the clinical manifestations of diabetes. When compared with non-diabetic subjects, diabetics demonstrate vascular abnormalities of the retina, kidneys, and fetus. Diabetics have impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. In each of these conditions, and possibly in diabetic neuropathy as well, abnormalities of angiogenesis can be implicated in the pathogenesis. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. In this review, the clinical features, molecular mechanisms, and potential therapeutic options of abnormal angiogenesis in diabetes will be reviewed.

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“…We have recently reported that diabetes-induced increased vascular permeability and polyol levels in new tissue formed in diabetic rats (27) are prevented by castration (27) and by an inhibitor of aldose reductase (29,30). Diabetes-induced increases in collagen crosslinking, which appear to be mediated by lysyl oxidase (31), were prevented by castration (which did not affect plasma glucose levels) but were unaffected by the aldose reductase inhibitor.…”

Section: Introductionmentioning

confidence: 98%

Galactose ingestion increases vascular permeability and collagen solubility in normal male rats.

et al. 1987

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In view of the similarity of cataracts and neuropathy in galactosefed and diabetic rats, the present experiments were undertaken to determine whether consumption of galactose-enriched diets (10, 25, or 50% by weight) also increases collagen crosslinking and permeation of vessels by 125I-albumin analagous to that observed in diabetic rats. The observations in these experiments: (a) demonstrate that consumption of galactose-enriched diets for 3 wk selectively increases '25I-albumin permeation of the same vascular beds affected in diabetic rats and by diabetic vascular disease in humans (i.e., the aorta and vessels in the eye, kidney, sciatic nerve, and new tissue formed in the diabetic milieu); (b) demonstrate that the susceptibility of the vasculature to aldose reductase-linked injury (increased permeability) varies greatly in different tissues; (c) indicate that collagen solubility (crosslinking) changes in galactose-fed rats differ sharply from those in diabetic rats; and (d) provide new evidence that consumption of galactose-enriched diets induces a hypogonadal state in male rats.

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Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil

Cited by 28 publications

References 32 publications

Effect of Rapid Normalization of Plasma Glucose Levels on Microvascular Dysfunction and Polyol Metabolism in Diabetic Rats

Effect of Rapid Normalization of Plasma Glucose Levels on Microvascular Dysfunction and Polyol Metabolism in Diabetic Rats

Abnormal angiogenesis in diabetes mellitus

Galactose ingestion increases vascular permeability and collagen solubility in normal male rats.

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