Diabetes impairs the late inflammatory response to wound healing

Fahey, Thomas J.; Sadaty, Anita; Jones, William G.; Barber, Annabel; Smoller, Bruce R.; Shires, G. Tom

doi:10.1016/0022-4804(91)90196-s

Cited by 249 publications

(159 citation statements)

References 19 publications

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“…40, 41 These conditions can be cause by a number of various pathophysiological conditions (diabetes, 42 venous stasis ulcer progression, 43 and others), though all causes generally lead to a hyper-inflammatory environment, particularly evidenced by the characteristic presence of neutrophils/high MMP activity that leads to high breakdown of new collagen during the wound healing process and inhibition of pro-healing factors (PDGF, TGF-B, and others). [44][45][46][47] This excessive inflammation phenotype leads to wounds that cannot resolve under normal circumstances, especially until the inflammation in the wound bed is controlled to a normal level and fibroblasts are able to effectively migrate into the wound space and synthesize new matrix.…”

Section: Chronic Skin Woundsmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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Section: Chronic Skin Woundsmentioning

confidence: 99%

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

2013

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“…Times of tissue harvest (day 1, 4, 7, and 10) were chosen based on results of time course assessments of liposomal IGF-1 gene transfer and the subsequent synthesis of IGF-1 protein. 30 Samples were immediately frozen in liquid nitrogen and stored at −80°C for further processing.…”

Section: Animalsmentioning

confidence: 99%

“…23,30 The liposome solution was made up of the cationic lipid DMRIE-C (1,2-dimyristyloxypropyl-3-dimethyl-hydroxyl ethyl ammonium bromide) and cholesterol in membrane-filtered water (DMRIE-C Reagent; Gibco BRL Life Technologies, Rockville, MD, USA). All lipid-DNA complexes were freshly prepared 2 h before injection.…”

Section: Animalsmentioning

confidence: 99%

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

et al. 2001

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“…Sildenafil dilates epicardial coronary arteries, improves endothelial dysfunction and inhibits platelet activation in patients with coronary artery disease (Halcox et al, 2002) and acutely enhances flow-mediated vasodilation in patient with heart failure (Hryniewicz et al, 2005). Wound healing constitutes a great challenge in the diabetic patients (Fahey et al, 1991). This challenge is seen both at the cellular and humoral levels involving white blood cells and their significant roles in the wound healing of diabetic rats administered sildenafil citrate (Tas et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

Mahre¹,

Umaru²,

Ngulde³

et al. 2017

Sokoto J. Vet. Sc.

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This study presents baseline data on the effect of sildenafil citrate on some of the haematological and biochemical parameters in wistar rats with diabetes and wound formation. Forty two albino rats weighing between 139 and 225 g were separated at random into seven groups (A, B, C, D, E, F and G) of six rats per group. Type 1 diabetes mellitus was induced in groups A, B, C and D by a single intra-peritoneal injection of 130 mg/kg Alloxan. Rats in group A were treated with orally dose of 50 mg/kg sildenafil citrate for 21 days and rats in group B were administered 10 IU of insulin intramuscularly once and sildenafil citrate as in Group A. The rats in group C were treated with a single dose of 10 IU of insulin intramuscularly, and rats in group D with only distilled water. Groups E and F were normal rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. Group G were normal rats without wound treated with sildenafil citrate as in Group A. Blood samples were taken before (day 0) and after the administration of the sildenafil citrate on day 7, 14 and 21. The results of the study showed significant decreased in red blood cells count from 6.28 ± 0.46 × 10 6 to 2.81 ± 0.46 × 10 6 in diabetic rats during the 14 days of treatment with sildenafil citrate, however, there was an indication that continues treatment for up to 21 days reduced the blood glucose and increased the red blood cells count and this may be an indication that sildenafil citrate improves insulin mediated glucose pathways.

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Diabetes impairs the late inflammatory response to wound healing

Cited by 249 publications

References 19 publications

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

Activity of mesenchymal stem cells in therapies for chronic skin wound healing

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

Haematological changes and wound healing effects of sildenafil citrate in diabetic albino rats

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