Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy

Bocci, Velio; Zanardi, Iacopo; Huijberts, M. S. P.; Travagli, Valter

doi:10.1016/j.dsx.2010.05.014

Cited by 41 publications

(32 citation statements)

References 67 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It increases the production of interferon, tumor necrosis factor, and interleukin-2, activating the immune system 15. Nowadays, the bactericidal effects of ozone therapy have been studied in detail and have been extensively reported in hepatitis B, diabetes mellitus, degenerative diseases, ischemic diseases, and so forth 16–18. In addition, many studies have also reported on available scientific evidence concerning the beneficial properties of ozone therapy of pain, resulting in ozone therapy being widely used in pain management 19,20.…”

Section: Introductionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

View full text Add to dashboard Cite

IntroductionWe investigated the effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia (PHN).MethodsNinety-eight patients with PHN were enrolled in this study and randomly divided into a pharmacological therapy group and ozone autohemotherapy group (49 patients in each group). The PHN patients in the pharmacological therapy group were administered pharmacological therapy for 2 weeks, whereas PHN patients in the ozone autohemotherapy group were given ozone autohemotherapy (200 mL blood from patients, the concentration of medical ozone was set as 30 μg/mL using an ozone medical apparatus, 40 mL medical ozone was incubated in 200 mL autologous blood for 3–5 minutes) combined with pharmacological therapy for 2 weeks. The Visual Analog Scale (VAS), the 50% VAS reduction in the initial value, McGill Pain Questionnaire (MPQ), the Patients’ Global Impression of Change (PGIC) scale, and the World Health Organization Quality of Life (WHOQOL-BREF) instrument were used to evaluate the outcomes of all PHN patients before therapy and at 1 week, 1 month, and 3 months after therapy.ResultsForty-five patients in the pharmacological therapy group and 47 patients in the ozone autohemotherapy group completed the study. Compared with before therapy, the two groups showed significant improvements in VAS, MPQ, PGIC, and WHOQOL-BREF scores after therapy (P<0.05). Moreover, compared with the scores of the pharmacological therapy group, the ozone autohemotherapy group’s scores were significantly improved in the VAS, MPQ, PGIC, and WHOQOL-BREF as well as the 50% VAS reduction of the initial value after therapy (P<0.05). Finally, there were no statistically significant differences in adverse effects between groups after therapy (P>0.05).ConclusionThe results of this study demonstrated that ozone autohemotherapy combined with pharmacological therapy was superior to isolated pharmacological therapy in patients with PHN and was an effective and safe way to relieve PHN.

show abstract

Section: Introductionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

View full text Add to dashboard Cite

show abstract

“…6. Lipodistrophy, seemingly due to ineffective leptin activity or/and fatty acids dysmetabolism, represents another aspect of the metabolic syndrome (Bocci et al, 2011).…”

Section: Diabetic Complicationmentioning

confidence: 99%

Diabetes, Oxidative Stress and Tea

Alipoor¹,

Rad²,

Mehrabany³

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

View full text Add to dashboard Cite

“…M-OOT has the scope of modifying the biological response especially to restore and enhance the antioxidant capacity of patients affected by inflammatory and age-associated disease states including typical vascular diseases (stroke, chronic heart disease and peripheral arterial diseases), [10] the dry form of macular degeneration, [4] and insulin-resistant linked type 2 diabetes. [11] The m-OOT is intended as an unspecific protein therapy causing physiological immune stimulation in patients with recurring viral infections such as herpes type I and II. [4] Ozone should be generated only when necessary and no storage is possible.…”

Section: Reliable and Doubtful Methods Of Ozone Administrationmentioning

confidence: 99%

“…A debate on using OOT in diabetes for delaying complications and improving the quality of life has been proposed. [11] Use of ozone for herniated disks…”

Section: Effects Of Clinical Ozone In Diabetesmentioning

confidence: 99%

Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Bocci

Zanardi

Borrelli

et al. 2011

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

Objectives This review aims to highlight the advantages and safety of oxygen-ozone therapy (OOT) and to suggest ways to enhance its acceptance. Key findings The treatment of a herniated disk by injecting a gaseous oxygen-ozone mixture inside the nucleus pulposus is a great clinical success. However, the use of OOT lags for a number of reasons, including lack of standardization, the need for numerous treatments, lack of knowledge and even denial. Anecdotally, several million treatments by OOT have been performed worldwide indicating its usefulness, mainly in peripheral arterial diseases and age-related macular degeneration. The scepticism that accompanies the systemic use of ozone can only be overcome by demonstrating the validity of OOT in controlled and randomized clinical trials. Cheaper and quicker methods, such as ozonating physiological saline with successive infusion as well as ozone rectal insufflations, are becoming popular, however, such alternative procedures are erratic, unstable and liable to be toxic, with deleterious consequences, and are likely to discredit the beneficial use of ozone. Summary The approval of ozone in terms of both therapeutic efficacy and safety will depend on the results achieved by authoritative clinical trials.

show abstract

Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy

Cited by 41 publications

References 67 publications

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Diabetes, Oxidative Stress and Tea

Reliable and effective oxygen-ozone therapy at a crossroads with ozonated saline infusion and ozone rectal insufflation

Contact Info

Product

Resources

About