DI-n-Octyl phthalate (DOP), a relatively ineffective peroxisome inducing straight chain isomer of the environmental contaminant DI(2-ethylhexyl)phthalate (DEHP), enhances the development of putative preneoplastic lesions in rat liver

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

“…The molecular features were extracted by screening the detected nodes at various retention times per minute, with a minimum intensity of 6,000 counts, and aligned with previously detected compounds considering adducts ([M + H] + , [M+2H] + , and [M-H] - ). The identified derivative metabolites were (peak A) P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ); (peak B) aloe-emodin ( Rehman et al, 2018 ); (peak C) oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ); (peak D) di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ); (peak E) apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ); (peak F) chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ); (peak G) nonacosan-10-ol, ( Yao et al, 2011 ); (peak H) lyciumate ( Rehman et al, 2019 ); and (peak I) betulinic acid ( Yao et al, 2011 ), and means m/z implies measured m/z.…”

“… Base peak chromatograms of the L. shawii methanolic extract were extracted, and tentatively identified secondary metabolites are as follows: P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ) (A), aloe-emodin ( Rehman et al, 2018 ) (B), oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ) (C), di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ) (D) , apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ) (E) , chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ) (F) , nonacosan-10-ol ( Yao et al, 2011 ) (G) , lyciumate ( Rehman et al, 2019 ) (H) , betulinic acid ( Yao et al, 2011 ) (I) , and m/z implies measured m/z . …”

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

“…The molecular features were extracted by screening the detected nodes at various retention times per minute, with a minimum intensity of 6,000 counts, and aligned with previously detected compounds considering adducts ([M + H] + , [M+2H] + , and [M-H] - ). The identified derivative metabolites were (peak A) P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ); (peak B) aloe-emodin ( Rehman et al, 2018 ); (peak C) oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ); (peak D) di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ); (peak E) apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ); (peak F) chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ); (peak G) nonacosan-10-ol, ( Yao et al, 2011 ); (peak H) lyciumate ( Rehman et al, 2019 ); and (peak I) betulinic acid ( Yao et al, 2011 ), and means m/z implies measured m/z.…”

“… Base peak chromatograms of the L. shawii methanolic extract were extracted, and tentatively identified secondary metabolites are as follows: P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ) (A), aloe-emodin ( Rehman et al, 2018 ) (B), oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ) (C), di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ) (D) , apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ) (E) , chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ) (F) , nonacosan-10-ol ( Yao et al, 2011 ) (G) , lyciumate ( Rehman et al, 2019 ) (H) , betulinic acid ( Yao et al, 2011 ) (I) , and m/z implies measured m/z . …”

Development and validation of a GC Orbitrap-MS method for the analysis of phthalate esters (PAE) and bis(2-ethylhexyl)adipate (DEHA) in atmospheric particles and its application for screening PM 2.5 from Curitiba, Brazil

“…18 DOP is a straight-chain DEHP isomer commonly used as an alternative plasticiser. 19 PAEs and DEHA have been previously observed in PM samples collected from various locations, e.g. rural (PM 2.5 from Guayama, Puerto Rico), 20 suburban (PM 2.5 from Mohali, India), 21 urban industrial (PM 2.5 from Guangzhou, China) 22 and urban residential (PM 2.5 and PM 10 from Mexico City, Mexico).…”

“…S5 †). Out of twenty samples, the pollutants were observed in the following number of PM 2.5 lter samples: DEHA (19), DEHP (15), DBP (5), and DOP (1). To the best of our knowledge, this is the rst report on the presence of PAEs and DEHA in PM of any size from Brazil.…”

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

“…Base diet concentrations of DEHP were measured at < 0.002%. Target doses of DEHP were based on the dose range of effects in prior long-term mouse and rat studies (David et al, 1999;Kluwe et al, 1982), whereas target doses of DNOP were based on effects described in previous short-term rat studies, including liver weight, histology, PPAR␣ activity, and promotional effects on diethylnitrosamine-induced hepatic foci (described in DeAngelo et al, 1986;Kavlock et al 2002). Estimated human dose equivalents of 0.12, 0.60, and 1.20% DEHP diets in mice are 13, 65, and 130 mg/kg/day, respectively (Kluwe et al, 1982).…”

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

“…The molecular features were extracted by screening the detected nodes at various retention times per minute, with a minimum intensity of 6,000 counts, and aligned with previously detected compounds considering adducts ([M + H] + , [M+2H] + , and [M-H] - ). The identified derivative metabolites were (peak A) P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ); (peak B) aloe-emodin ( Rehman et al, 2018 ); (peak C) oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ); (peak D) di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ); (peak E) apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ); (peak F) chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ); (peak G) nonacosan-10-ol, ( Yao et al, 2011 ); (peak H) lyciumate ( Rehman et al, 2019 ); and (peak I) betulinic acid ( Yao et al, 2011 ), and means m/z implies measured m/z.…”

“… Base peak chromatograms of the L. shawii methanolic extract were extracted, and tentatively identified secondary metabolites are as follows: P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ) (A), aloe-emodin ( Rehman et al, 2018 ) (B), oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ) (C), di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ) (D) , apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ) (E) , chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ) (F) , nonacosan-10-ol ( Yao et al, 2011 ) (G) , lyciumate ( Rehman et al, 2019 ) (H) , betulinic acid ( Yao et al, 2011 ) (I) , and m/z implies measured m/z . …”

Development and validation of a GC Orbitrap-MS method for the analysis of phthalate esters (PAE) and bis(2-ethylhexyl)adipate (DEHA) in atmospheric particles and its application for screening PM 2.5 from Curitiba, Brazil

“…18 DOP is a straight-chain DEHP isomer commonly used as an alternative plasticiser. 19 PAEs and DEHA have been previously observed in PM samples collected from various locations, e.g. rural (PM 2.5 from Guayama, Puerto Rico), 20 suburban (PM 2.5 from Mohali, India), 21 urban industrial (PM 2.5 from Guangzhou, China) 22 and urban residential (PM 2.5 and PM 10 from Mexico City, Mexico).…”

“…S5 †). Out of twenty samples, the pollutants were observed in the following number of PM 2.5 lter samples: DEHA (19), DEHP (15), DBP (5), and DOP (1). To the best of our knowledge, this is the rst report on the presence of PAEs and DEHA in PM of any size from Brazil.…”

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

“…Base diet concentrations of DEHP were measured at < 0.002%. Target doses of DEHP were based on the dose range of effects in prior long-term mouse and rat studies (David et al, 1999;Kluwe et al, 1982), whereas target doses of DNOP were based on effects described in previous short-term rat studies, including liver weight, histology, PPAR␣ activity, and promotional effects on diethylnitrosamine-induced hepatic foci (described in DeAngelo et al, 1986;Kavlock et al 2002). Estimated human dose equivalents of 0.12, 0.60, and 1.20% DEHP diets in mice are 13, 65, and 130 mg/kg/day, respectively (Kluwe et al, 1982).…”

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies

“…The molecular features were extracted by screening the detected nodes at various retention times per minute, with a minimum intensity of 6,000 counts, and aligned with previously detected compounds considering adducts ([M + H] + , [M+2H] + , and [M-H] - ). The identified derivative metabolites were (peak A) P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ); (peak B) aloe-emodin ( Rehman et al, 2018 ); (peak C) oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ); (peak D) di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ); (peak E) apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ); (peak F) chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ); (peak G) nonacosan-10-ol, ( Yao et al, 2011 ); (peak H) lyciumate ( Rehman et al, 2019 ); and (peak I) betulinic acid ( Yao et al, 2011 ), and means m/z implies measured m/z.…”

“… Base peak chromatograms of the L. shawii methanolic extract were extracted, and tentatively identified secondary metabolites are as follows: P-coumaric acid (4-hydroxycinnamic acid) ( Pei et al, 2016 ) (A), aloe-emodin ( Rehman et al, 2018 ) (B), oxalic acid isobutyl pentyl ester (2-methylpropyl pentyl ethanedioate) ( Singariya et al, 2015 ) (C), di-n-octyl phthalate (dioctyl 1,2 benzenedicarboxylate) ( DeAngelo et al, 1986 ) (D) , apigenin (4,5,6-trihydroxy flavone) ( Shukla and Gupta, 2010 ) (E) , chrysophanol-8-O-β-D-glucoside ( Rehman et al, 2016 ) (F) , nonacosan-10-ol ( Yao et al, 2011 ) (G) , lyciumate ( Rehman et al, 2019 ) (H) , betulinic acid ( Yao et al, 2011 ) (I) , and m/z implies measured m/z . …”

Development and validation of a GC Orbitrap-MS method for the analysis of phthalate esters (PAE) and bis(2-ethylhexyl)adipate (DEHA) in atmospheric particles and its application for screening PM 2.5 from Curitiba, Brazil

“…18 DOP is a straight-chain DEHP isomer commonly used as an alternative plasticiser. 19 PAEs and DEHA have been previously observed in PM samples collected from various locations, e.g. rural (PM 2.5 from Guayama, Puerto Rico), 20 suburban (PM 2.5 from Mohali, India), 21 urban industrial (PM 2.5 from Guangzhou, China) 22 and urban residential (PM 2.5 and PM 10 from Mexico City, Mexico).…”

“…S5 †). Out of twenty samples, the pollutants were observed in the following number of PM 2.5 lter samples: DEHA (19), DEHP (15), DBP (5), and DOP (1). To the best of our knowledge, this is the rst report on the presence of PAEs and DEHA in PM of any size from Brazil.…”

Comparative Time Course Profiles of Phthalate Stereoisomers in Mice

“…Base diet concentrations of DEHP were measured at < 0.002%. Target doses of DEHP were based on the dose range of effects in prior long-term mouse and rat studies (David et al, 1999;Kluwe et al, 1982), whereas target doses of DNOP were based on effects described in previous short-term rat studies, including liver weight, histology, PPAR␣ activity, and promotional effects on diethylnitrosamine-induced hepatic foci (described in DeAngelo et al, 1986;Kavlock et al 2002). Estimated human dose equivalents of 0.12, 0.60, and 1.20% DEHP diets in mice are 13, 65, and 130 mg/kg/day, respectively (Kluwe et al, 1982).…”