Di‐n‐butyltin aminoarylcarboxylates: structure, properties and in vitro antitumor activity

Abstract

4 ] (3) are described. Complex 3 adopts a structure with a tetranuclear Sn 4 (m 3 -O) 2 core. All tin atoms are five-coordinate and form bonds with three oxygen atoms and two butyl ligands. Two carboxylates are bridging and two are terminal ligands. IR and NMR spectra indicate that the same structure is adopted by complexes 1 and 2. The molecular and electronic structures of complex 1 of C i symmetry have been studied using the semi-empirical PM3 formalism. The calculated structure and bond distances agree with X-ray data. All complexes are effective antitumor agents.

On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3-amino and 4-aminobenzoic acids

“…In particular the 1 J SnC coupling of the a-carbon of the alkyl or aryl tin substituent or in its absence the 2 J SnH of the b-hydrogen are indicative of the coordination environment of tin [28][29][30]. In the cases of the studied compounds where it was possible to observe such a splitting it is apparent that in chloroform the coupling constants vary between 360 and 400 Hz, indicating a tetrahedral environment for tin and therefore monomeric units with monodentate or at least extremely asymmetric chelating carboxylate, while in DMSO the corresponding values lie well above 440 Hz and in 1a reach even 526 Hz, indicating a higher coordination number [31].…”