DHF-BAHPC molecule exerts ameliorative antioxidant status and reduced cadmium-induced toxicity in zebrafish (Danio rerio) embryos

Mohankumar, Thangavel; Lalithamba, Haralur Shankaraiah; Krishnan, Manigandan; Muthaiyan, Arunachalam; Elangovan, Namasivayam

doi:10.1016/j.etap.2020.103425

Cited by 7 publications

(2 citation statements)

References 58 publications

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“…(2021) found that zebrafish embryo exposure to 10 µM bisphenol A (BPA) with 0.5 µM Cd or Cr for 96 h induced malformations, significantly increased oxidative stress and induced apoptosis, and showed a synergistic effect at common noneffective doses. Zebrafish have also been used for the research and development of detoxification substances and their mechanisms of action (Mohankumar et al., 2020). For example, dietary selenium supplementation was found to reduce the accumulation of MeHg in zebrafish muscle and enhance the elimination of MeHg in zebrafish polluted by mercury (Amlund et al., 2015).…”

Section: Research Progress In the Toxicological Assessment Of Hazards...mentioning

confidence: 99%

Zebrafish as model organisms for toxicological evaluations in the field of food science

Hou

Liu

Qin

et al. 2023

Comp Rev Food Sci Food Safe

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Food safety has long been an area of concern. The selection of stable and efficient model organisms is particularly important for food toxicology studies. Zebrafish (Danio rerio) are small model vertebrates, and 70% of human genes have at least one zebrafish ortholog. Zebrafish have advantages as model organisms due to their short life cycle, strong reproductive ability, easy rearing, and low cost. Zebrafish embryos have the advantage of being sensitive to the breeding environment and thus have been used as biosensors. Zebrafish and their embryos have been widely used for food toxicology assessments. This review provides a systematic and comprehensive summary of food toxicology studies using zebrafish as model organisms. First, we briefly introduce the multidimensional mechanisms and structure–activity relationship studies of food toxicological assessment. Second, we categorize these studies according to eight types of hazards in foods, including mycotoxins, pesticides, antibiotics, heavy metals, endocrine disruptors, food additives, nanoparticles, and other food‐related ingredients. Finally, we list the applications of zebrafish in food toxicology studies in line with future research prospects, aiming to provide a valuable reference for researchers in the field of food science.

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Section: Research Progress In the Toxicological Assessment Of Hazards...mentioning

confidence: 99%

Zebrafish as model organisms for toxicological evaluations in the field of food science

Hou

Liu

Qin

et al. 2023

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

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“…Fang et al pointed out that 7,8-DHF can attenuate oxidative stress injury of the optic nerve and retinal ganglion cells induced by chronic intermittent hypoxia, and its mechanism may be through the activation of the BDNF/TrkB signaling pathway [ 174 ]. DHF-BAHPC, a flavonoid derivative synthesized by Thangavel et al , has strong antioxidant activity and can scavenge free radicals 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), ferric reducing antioxidant power (FRAP), and H 2 O 2 in zebrafish [ 175 ]. Glutamate is an important excitatory neurotransmitter in CNS, but excessive glutamate can lead to neuronal dysfunction and degeneration, which is associated with the occurrence of neurodegenerative diseases, such as PD and AD [ 176 - 178 ].…”

Section: Development Potential and Challenges Coexistmentioning

confidence: 99%

7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development

Yang

Zhu

2022

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: 7,8-Dihydroxyflavone (7,8-DHF) is a kind of natural flavonoids, with the potential to cross the blood-brain barrier. 7,8-DHF effectively mimics the effect of brain-derived neurotrophic factor (BDNF) in the brain to selectively activate tyrosine kinase receptor B (TrkB) and downstream signaling pathways, thus playing a neuroprotective role. The preclinical effects of 7,8-DHF have been widely investigated in the neuropsychiatric disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), depression and memory impairment. Besides the effect on TrkB, 7,8-DHF could also function through fighting against oxidative stress, cooperating with estrogen receptors or regulating intestinal flora. This review focuses on the recent experimental studies on depression, neurodegenerative diseases and learning and memory function. Additionally, the structural modification and preparation of 7,8-DHF were also concluded and proposed, hoping to provide reference for the follow-up research and clinical drug development of 7,8-DHF in the field of neuropsychiatric disorders.

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7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance

2021

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DHF-BAHPC molecule exerts ameliorative antioxidant status and reduced cadmium-induced toxicity in zebrafish (Danio rerio) embryos

Cited by 7 publications

References 58 publications

Zebrafish as model organisms for toxicological evaluations in the field of food science

Zebrafish as model organisms for toxicological evaluations in the field of food science

7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development

7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance

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