Dextrose prolotherapy and corticosteroid injection into rat Achilles tendon

Abstract

Dextrose was not deleterious to the tendinous tissue, as it did not change the mechanical and histological properties of Achilles tendons in rats. The data obtained in this study may help clinicians in their daily work as they suggest that injections of 12.5% dextrose caused no harm to the tendons, although the clinical importance in humans still needs to be defined.

The effect of sclerotherapy and prolotherapy on chronic painful Achilles tendinopathy—a systematic review including meta‐analysis

“…To make the information more easily accessible, we categorized the studies in three units consisting of sclerotherapy, prolotherapy, and animal studies. We identified nine studies assessing sclerosing agents, five dealing with prolotherapy, and four investigating one of the two interventions in animals . Regarding the study type, we obtained four randomized controlled trials comparing the injection intervention to placebo, alternative dosages, surgery or eccentric loading, seven non‐controlled prospective studies, two retrospective studies, and one case report .…”

“…The horses continued to prosper without revealing any signs of suffering during the post‐injection period until veterinary euthanasia. The most important finding from the controlled trial by Martins et al . was that administering a dextrose solution did not weaken tendons or alter their characteristics.…”

Conservative Management of Second Metatarsophalangeal Joint Instability in a Professional Dancer: A Case Report

“…1,30,31 A gentle irritant solution injected to a localized area creates a mild, controlled injury that stimulates the body's natural healing mechanisms to develop new collagen fibers, resulting in tightening of the weakened structure. 26,30,46,60 Additional treatments repeat this process, allowing a gradual build-up of tissue to restore the original strength of the area. Studies report that prolotherapy is helpful in treating tendinopathies and ligament sprains, 12,38,39,44,72 joint instabilities, 20,25,32,62,68,75,83 osteoarthritis, [57][58][59]61 and chronic musculoskeletal pain and low back pain when coupled with spinal manipulation or corticosteroid injections.…”

Technical Innovation Case Report: Ultrasound-Guided Prolotherapy Injection for Insertional Achilles Calcific Tendinosis

“…Prolotherapy is a relatively safe procedure, with no evidence that points towards decreased tensile strength or increased risk of tendon rupture [2, 4]. One study evaluated radiographic evidence of tendon repair under ultrasonography after prolotherapy treatment that showed reductions in size and severity of hypoechoic regions and intratendinous tears as well as improvements in neovascularity [3].…”