Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro

Berry, Catherine C.; Wells, S.; Charles, S.W.; Curtis, Adam

doi:10.1016/s0142-9612(03)00237-0

Cited by 481 publications

(284 citation statements)

References 28 publications

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“…Thus, rendering multicellular spheroids with magnetic functionality is deemed important for assembly of artificial tissues, and magnetic nanoparticles have been introduced into cells prior to fabrication of spheroids [9]. Importantly, PAH-stabilized MNPs are equally applicable to both primary and malignant cells, whereas earlier reports suggest different ways to functionalize cancer and normal cells [45,46]. Magnetic functionality in spherical tissue engineering blocks is pivotal for the effective positioning and retention of spheroids at desired areas during tissue build-up.…”

Section: Fabrication Of Layered Planar Tissue Constructs and Multicelmentioning

confidence: 99%

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

et al. 2015

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Regenerative medicine requires new ways to assemble and manipulate cells for fabrication of tissue-like constructs. Here we report a novel approach for cell surface engineering of human cells using polymer-stabilized magnetic nanoparticles (MNPs). Cationic polyelectrolyte-coated MNPs are directly deposited onto cellular membranes, producing a mesoporous semi-permeable layer and rendering cells magnetically responsive. Deposition of MNPs can be completed within minutes, under cell-friendly conditions (room temperature and physiologic media). Microscopy (TEM, SEM, AFM, and enhanced dark-field imaging) revealed the intercalation of nanoparticles into the cellular microvilli network. A detailed viability investigation was performed and suggested that MNPs do not inhibit membrane integrity, enzymatic activity, adhesion, proliferation, or cytoskeleton formation, and do not induce apoptosis in either cancer or primary cells. Finally, magnetically functionalized cells were employed to fabricate viable layered planar (two-cell layers) cell sheets and 3D multicellular spheroids.

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Section: Fabrication Of Layered Planar Tissue Constructs and Multicelmentioning

confidence: 99%

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

et al. 2015

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“…Magnetic nanoparticles ͑MNPs͒ are promising candidates for biomedical applications such as cell sorting and magnetic separation, [1][2][3] where target biological analytes are labeled with MNPs and then separated from the unwanted entities using a fluid-based magnetic separation technique. 4,5 For this application, the MNPs should be uniform in shape, size, and composition and exhibit high magnetic moment for low external applied field and low magnetic moment at zero field.…”

Section: Introductionmentioning

confidence: 99%

Structural and magnetic characterizations of high moment synthetic antiferromagnetic nanoparticles fabricated using self-assembled stamps

Koh

Wilson

et al. 2010

Journal of Applied Physics

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High-moment synthetic antiferromagnetic ͑SAF͒ nanoparticles were produced using 4 in. diameter stamps made by self-assembly and nanosphere lithography of latex nanospheres. This leads to a significant increase in particle yield over a pre-existing technique which utilizes a 1 cm 2 stamp patterned using e-beam lithography. Changes in nanopillar dimensions from the self-assembled stamps and variations in the associated processing conditions can lead to the fabrication of particles with different dimensions. We demonstrate that it is possible to produce reasonably uniformly sized SAFs with diameters from 70 nm upward using self-assembled stamps. The particles exhibit low remanence at low externally applied magnetic fields, and that the saturation magnetization more than double that for conventional iron oxide nanoparticles.

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“…13,14 There is evidence that bare IONs can reduce microfilament formation and disrupt actin distribution within the main bodies of the cells, resulting in smaller cells with smaller structures and a spherical shape.…”

mentioning

confidence: 99%

“…12,17,18 All these toxic effects could be significantly eliminated by use of biocompatible coatings, such as dextran, 13,14,17,19 …”

mentioning

confidence: 99%

Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)

Ebrahiminezhad¹,

Ghasemi²,

Rasoul‐Amini³

et al. 2012

Bulletin of the Korean Chemical Society

145

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Iron-oxide nanoparticles (IONs) with biocompatible coatings are the only nanostructural materials which have been approved by the FDA for clinical use. Common biocompatible coatings such as hydrocarbons, polymers, and silica have profound influences on critical characteristics of IONs. Recently, amino acids were introduced as a novel biocompatible coating. In the present study, the effects of amino acids on IONs synthesis and characteristics have been evaluated. Magnetite nanoparticles with L-arginine and L-lysine coatings were synthesised by a coprecipitation reaction in aqueous solvent and their characteristics were compared with naked magnetite nanoparticles. The results showed that amino acids can be a perfect coating for IONs and would increase particle stability without any significant effects on the critical properties of nanoparticles such as particle size and magnetization saturation value.

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Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro

Cited by 481 publications

References 28 publications

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

Structural and magnetic characterizations of high moment synthetic antiferromagnetic nanoparticles fabricated using self-assembled stamps

Impact of Amino-Acid Coating on the Synthesis and Characteristics of Iron-Oxide Nanoparticles (IONs)

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