Dexmedetomidine preconditioning protects against lipopolysaccharides-induced injury in the human alveolar epithelial cells

Zhang, Lei; Zhou, Xianjin; Li, Zhan; Wu, Xiaojing; Li, Wenlan; Zhao, Bo; Meng, Qingtao; Xia, Zhongyuan

doi:10.1016/j.bjane.2017.02.002

Cited by 3 publications

(4 citation statements)

References 34 publications

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“… 12 Previous studies have also reported that DEX prevents peroxidation by increasing SOD and decreasing MDA. 7 Our results also show that DEX preconditioning results in an increase of SOD activity and a decrease of MDA content in lung tissue during ischemia and reperfusion. These findings suggest that DEX pretreatment can prevent the oxidative damage of lung tissue during ischemia and reperfusion.…”

Section: Discussionsupporting

confidence: 73%

“…To date, the mechanism of ischemic preconditioning has been extensively studied and found that its protective effect can be mimicked by many drugs more safely, such as Dexmedetomidine (DEX). 6 , 7 …”

Section: Introductionmentioning

confidence: 99%

“…DEX is often used as a sedative in clinical and the researchers recently found that DEX can simulate the effect of pretreatment, and showed a protective effect on human alveolar epithelial cell in vitro. 7 There is evidence that DEX may have a protective effect on lung injury in vivo. Here we use a hemorrhagic shock model to investigate whether DEX pretreatment produces protection against lung injury.…”

Section: Introductionmentioning

confidence: 99%

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Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats

Zhang

Wang

Qiao

et al. 2019

Brazilian Journal of Anesthesiology (English Edition)

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats

Zhang

Wang

Qiao

et al. 2019

Brazilian Journal of Anesthesiology (English Edition)

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“…Chen et al found that Dex alleviated the lung inflammation and improved the lung function through affecting the oxygenation state and Cdyn and inhibiting inflammatory factors [9] . UTI is a protease inhibitor extracted from human urine, which can exert an antiinflammatory effect via inhibiting the hydrolysis of various enzymes [10] . It has been confirmed that UTI can reduce cardiopulmonary bypass-associated lung injury [11] .…”

mentioning

confidence: 99%

Protective Effects of Ulinastatin Combined with Dexmedetomidine on Patients Undergoing One Lung Ventilation

Fan¹,

Tian²,

Chen³

et al. 2021

ijps

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Fan et al.: Combined Effects of Ulinastatin and Dexmedetomidine on OLV PatientsTo evaluate the protective effects of ulinastatin combined with dexmedetomidine on patients undergoing one lung ventilation. A total of 100 patients who underwent thoracoscopic partial lobectomy in our hospital were selected and randomly divided into control group (Group N), ulinastatin pretreatment group (Group U), dexmedetomidine continuous pumping group (Group D) and combined treatment group (Group U+D) (n=25). Their intraoperative data and objective indices reflecting the lung function at T1, T2 and T3 were compared. The expression levels of inflammatory factors were compared at T0, T1, T2, T3 and T4. Lung dynamic compliance and oxygenation index rose first and then declined, while respiratory index declined first and then rose in all patients from T1 to T3. At T3, lung dynamic compliance and oxygenation index were significantly higher, while respiratory index was significantly lower in Group U+D than those in the other groups (p<0.05). lung dynamic compliance, oxygenation index and respiratory index had significant differences in Group U and D compared with those in Group N, but they had no significant differences between Group U and D (p>0.05). The levels of inflammatory factors rose first and then declined in all patients from T0 to T4. At T3 and T4, the levels of pro-inflammatory factors were significantly lower, while the level of anti-inflammatory factor was significantly higher in Group U+D than those in the other groups (p<0.05). The levels of inflammatory factors had significant differences in Group U and D compared with those in Group N (p<0.05), but they had no statistically significant differences between Group U and D (p>0.05). Group U+D had a significantly lower incidence rate of postoperative pulmonary complications and a significantly shorter length of stay after surgery than those of Group U, D and N (p<0.05). Dexmedetomidine and ulinastatin can alleviate the damage caused by one lung ventilation to the lung to a certain extent and the combination of them has the optimum effect.

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Pré‐condicionamento com dexmedetomidina protege contra lesão pulmonar em ratos com choque hemorrágico

Zhang

Wang

Qiao

et al. 2019

Brazilian Journal of Anesthesiology

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Dexmedetomidine preconditioning protects against lipopolysaccharides-induced injury in the human alveolar epithelial cells

Cited by 3 publications

References 34 publications

Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats

Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats

Protective Effects of Ulinastatin Combined with Dexmedetomidine on Patients Undergoing One Lung Ventilation

Pré‐condicionamento com dexmedetomidina protege contra lesão pulmonar em ratos com choque hemorrágico

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