2015
DOI: 10.1038/srep16849
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Abstract: Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-кB(NF-кB) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-induced AKI is associated with inflammatory response, and to assess the effects of dexmedetomidine pretreatment on kidneys in rats following orthotopic autologous liver transplantation(OALT). Seventy-seven adult mal… Show more

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Cited by 48 publications
(36 citation statements)
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“…The significant increase in expression of NF‐κB, TLR2, and TLR4 within kidney tissues indicating that renal TLR4/NF‐κB pathway was activated. This result was in harmony with Yao et al . Following injury of renal tubular epithelial cells (TECs), a cascade of proinflammatory mediators that can lead to amplification of injury is activated.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…The significant increase in expression of NF‐κB, TLR2, and TLR4 within kidney tissues indicating that renal TLR4/NF‐κB pathway was activated. This result was in harmony with Yao et al . Following injury of renal tubular epithelial cells (TECs), a cascade of proinflammatory mediators that can lead to amplification of injury is activated.…”
Section: Discussionsupporting
confidence: 78%
“…[36] The significant increase in expression of NF-B, TLR2, and TLR4 within kidney tissues indicating that renal TLR4/NF-B pathway was activated. This result was in harmony with Yao et al [37] Following injury of renal tubular epithelial cells (TECs), a cascade of proinflammatory mediators that can lead to amplification of injury is activated. As TECs belong to the non-immune cells that express and upregulate TLR2 after ischemic injury, it might be hypothesized that this TEC-associated receptor as megalin plays a key role in the initiation of inflammation after renal ischemia.…”
Section: Discussionsupporting
confidence: 77%
“…In correspondence with previous electronmicroscopic and functional studies (Aoki et al, 1998;Hutchinson et al, 2011), we also found immunopositive staining in reactive astrocytes in the lesioned regions, which was most prominent during the 1 st month after post-TBI. This led us to investigate whether ATI affects the release of inflammatory cytokines, as suggested by previous studies in models of brain, lung, and kidney injury (Chi et al, 2015;Yao et al, 2015;Ren et al, 2016). Moreover, whether the alleviation of inflammation-related odema by ATI could explain some of the enhanced somatomotor recovery.…”
Section: Target Expression and Mechanisms Of Action Of Atimentioning
confidence: 86%
“…52 Western blot analyses were performed with anti-Brg1 (1:1000), anti-Nrf2 (1:1000), anti-HO-1 (1:250), anti-NQO1 (1:250), anti-lamin B2 (1:2000) and anti- β -actin (1:2000) antibodies.…”
Section: Methodsmentioning
confidence: 99%