Dexmedetomidina retal em ratos: avaliação dos efeitos sedativos e sobre a mucosa

Hancı, Volkan; Gülle, Kanat; Karakaya, Kemal; Yurtlu, Serhan; Akpolat, Meryem; Yuce, Mehmet Fatih; Yüce, Fatma Zehra; Turan, İşıl Özkoçak

doi:10.1016/j.bjan.2013.09.004

Cited by 3 publications

(2 citation statements)

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“…The unclear image of tissue after HE staining caused tissue scoring could not completely made. The inflamed colon should show mucus depletion, epithelium destruction, edema, erosion of the colonic crypts and infiltration of inflammatory cells (Hanci et al, 2015;Minaiyan et al, 2021;Radulovic et al, 2018). Macroscopically, colon condition was clearly improved.…”

Section: Apium Graveolens Ethanolic-extract Restore Enterobacteriacea...mentioning

confidence: 99%

“…Colitis is triggered with single per rectal administration of 4% AA. Five hundred microliter of AA is per rectally injected with 1 mL syringe and 22 G canula, following per rectal application previously explained by (Hanci et al, 2015). Animal treatment with EES and 5-ASA are done for five consecutive days starting the sixth days of per rectal AA administration.…”

Section: Animal Maintenance and Treatmentmentioning

confidence: 99%

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Apium graveolens Herbs Ethanolic-Extract Improve Acetic Acid–Induced Colitis Condition in Rats

Sahid,

Dewangga,

Saputra

et al. 2024

Indonesian J Pharm

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Colitis is a growing gastrointestinal inflammation condition that affect individual all around the globe. No specific treatment for colitis condition is available at the moment and this disease can develop into colorectal cancer. Phytochemical in Apium graveolens (AG) are potential as anti-inflammation and antioxidant. This study aimed to investigate the potency of AG ethanolic-extract (EES) in improving acetic acid (AA) – induced colitis in rats. Rats with colitis induced by acetic acid were treated with 5-ASA and several concentrations (100, 300, and 900 mg/kg) of EES. Colitis severity was determined by scoring of macroscopic condition including body weight, colon, and faeces condition. In addition, colon tissues conditions were observed with haematoxylin-eosin staining. Colon permeability is determined by measuring urine glucose level. The observation of the change in Enterobacteriaceae population is investigated using PCR. Apium graveolens ethanolic-extract shows highest improvement of colitis condition at concentration of 900 mg/kg, based on macroscopic observation and disease severity index. At this dose, no blood existed on the faeces and the faeces consistency is solid. Group receiving lower dose of EES still shows blood existence and less solid faeces. The EES dose dependently return the population of Enterobacteriaceae which increase upon AA treatment. Apium graveolens is potential to be use as preventive or treatment for colitis.

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Section: Apium Graveolens Ethanolic-extract Restore Enterobacteriacea...mentioning

confidence: 99%

Section: Animal Maintenance and Treatmentmentioning

confidence: 99%

Apium graveolens Herbs Ethanolic-Extract Improve Acetic Acid–Induced Colitis Condition in Rats

Sahid,

Dewangga,

Saputra

et al. 2024

Indonesian J Pharm

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Sedation With Intracloacal Administration of Dexmedetomidine and Ketamine in Yellow-bellied Sliders ( Trachemys scripta scripta )

Morici

Interlandi

Costa

et al. 2017

Journal of Exotic Pet Medicine

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Models of Ischemic Stroke (Review)

Голубев

2020

Obŝaâ reanimatologiâ

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The incidence of ischemic stroke remains high in many countries, despite a declining trend in the incidence of brain circulation disorders. Limited knowledge of the pathogenesis, diagnosis, clinical presentation, and treatment of this life-threatening disease can be complemented by modelling of ischemic stroke on animals, particularly, in rodents (rats, mice).The aim of review: to provide a rationale for choosing an optimal model of human ischemic stroke.Among more than 300 primary literature sources from various databases (Scopus, Web of science, RSCI, etc.), 84 sources were selected for evaluation, of which 72 were published in the recent years (2015–2019). The criteria for exclusion of sources were low relevance and outdated data.The review examined six experimental models of acute cerebrovascular events including middle cerebral artery occlusion, embolic stroke model; phototrombosis; models using thrombin, endothelin-1 and electrocoagulation of the middle cerebral artery.The review outlines the factors inﬂuencing reliability and reproducibility of research results, related to adherence to the rules of animal accommodation and acclimatization, nutrition and care, selection of anesthesia and pain relief methods, compliance with aseptic techniques, monitoring of basic physiological parameters at all stages of the ischemic stroke modeling experiment, with humane withdrawal of animals from the experiment.It was concluded that the model of ischemic stroke, based on the occlusion of the middle cerebral artery, is most promising as being the closest to features of human ischemic stroke and enabling to obtain reproducible results in the experiment.

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Dexmedetomidina retal em ratos: avaliação dos efeitos sedativos e sobre a mucosa

Cited by 3 publications

References 36 publications

Apium graveolens Herbs Ethanolic-Extract Improve Acetic Acid–Induced Colitis Condition in Rats

Apium graveolens Herbs Ethanolic-Extract Improve Acetic Acid–Induced Colitis Condition in Rats

Sedation With Intracloacal Administration of Dexmedetomidine and Ketamine in Yellow-bellied Sliders ( Trachemys scripta scripta )

Models of Ischemic Stroke (Review)

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