Device for modeling of intra-arterial circulation: application in experimental cardiology

Germanova, Olga; Germanov, Vladimir; Shchukin, Y.; Germanov, Andrey; Galati, Giuseppe

doi:10.1093/eurheartj/ehab724.0299

Cited by 5 publications

(7 citation statements)

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“…Secondly, in our work, we focused on studying the features of hemodynamics and kinetics during the passage of the pulse wave of the first post-extrasystolic contraction in the arteries, showing its potential danger. Moreover, our clinical findings were subsequently confirmed by the experimental part of the work using the "Device for the modeling of intra-arterial circulation", which is described in detail in a previously published article [19].…”

Section: Methodssupporting

confidence: 73%

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Premature Ventricular Contractions as an Additional Risk Factor for the Arterial Thromboembolism

Germanova¹,

Galati²,

Воронин³

et al. 2023

ArveMED

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Premature ventricular contractions (PVCs) are not included in the risk factors for arterial thromboembolism. Aim: To determine the relationship between PVCs and the development of arterial thromboembolic complications. Methods: The study included 440 patients with PVCs 700 or more per 24 hours, control group - 88 people with PVCs less than 700. All patients underwent laboratory and instrumental studies: lipid spectrum, hemostasis indicators; 24-hours ECG monitoring; echocardiography (EchoCG); Doppler ultrasound and digital sphygmography (SG) of the main arteries; ultrasound of the aorta branches, renal arteries. According to the indications - stress EchoCG with physical exercises, coronary angiography, pancerebral angiography, renal arteries angiography, computed tomography, magnetic resonance imaging of the brain. All patients of the main group were divided into 2 subgroups, depending on the moment of occurrence of PVCs ventricular systole in the cardiac cycle, regardless of the ectopic center: subgroup A (120) - patients with PVCs before the peak of transmitral blood flow; subgroup B (320) - after the peak of the transmitral blood flow. Patients were observed during 1 year and the development of arterial thromboembolic events was analyzed. Results: According to the main clinical, laboratory and instrumental data, patients of subgroups A, B and the control group were equivalent. Also, during 1 year, a statistically significantly higher development of arterial thromboembolic events was observed in subgroup A. When comparing linear blood flow velocity and volumetric blood flow, there was a significant increase in parameters during the spreading of the first post-extrasystolic contraction wave. A similar trend was observed in the parameters of the kinetics of the arterial vascular wall (velocity, acceleration, power, work). Conclusion: PVCs are an additional risk factor for arterial thromboembolic events. The main danger is not the PVC itself, but the wave of the first post-extrasystolic contraction, which can become the starting point for the instability of atherosclerotic plaques, leading to tears, parietal thrombosis, and embolism in the arterial vessels.

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Section: Methodssupporting

confidence: 73%

“…However, in these patients all traditional risk factors for the development of stroke were excluded. A number of foreign studies described a higher incidence of strokes in patients with frequent PVCs [14][15][16][17][18][19]. However, until now, PVCs has not been included in the list of risk factors for arterial thromboembolic events.…”

Section: Introductionmentioning

confidence: 99%

Premature Ventricular Contractions as an Additional Risk Factor for the Arterial Thromboembolism

Germanova¹,

Galati²,

Воронин³

et al. 2023

ArveMED

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“…Выявленные клинические закономерности были подтверждены нами экспериментальной работой с применением разработанного и запатентованного "Устройства для моделирования внутриартериального кровообращения" [15].…”

Section: Discussionunclassified

Maximum time between cardiac cycles in atrial fibrillation for assessing the risk of arterial thromboembolism

2022

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Aim. To assess the development of thromboembolic events in different types of atrial fibrillation (AF), which differ in the maximum time between cardiac cycles.Material and methods. The main group included 80 patients with permanent AF, while the control one — 88 people without AF. The following investigations were performed: echocardiography, 24-hour electrocardiographic (ECG) monitoring; ultrasound of extracranial arteries, aortic branches, lower limb arteries; sphygmography of the common carotid and posterior tibial arteries. If required, coronary angiography, cerebral angiography, brain computed tomography were performed. According to 24-hour ECG monitoring, all patients of the main group were divided into 2 subgroups (A and B) depending on the maximum time between cardiac cycles in AF: subgroup A (n=42) — patients with a maximum time between cardiac cycles <1,5 seconds, subgroup B (n=38) — ≥1,5. The followup period lasted 1 year. During the follow-up period, the development of arterial thromboembolic events was analyzed.Results. The patients were comparable in key paraclinical characteristics and comorbidity profile. One-year follow-up period revealed a significantly higher incidence of stroke, transient ischemic attack, myocardial infarction, and distal arterial embolism of lower limb arteries in subgroup B. With an increase in the maximum time between cardiac cycles in AF, an increase in hemodynamic parameters of arterial vessels occurred as both proximal and distal arteries. A similar trend was also observed in the analysis of arterial kinetic parameters.Conclusion. Not only the fact of AF presence is important for assessing the risk of arterial thromboembolism, but also its features. The most unfavorable for prognosis is AF with a maximum time between cardiac cycles ≥1,5 seconds. An increase in intra-arterial hemodynamic parameters after a long pause between ventricular contractions in AF without intracardiac thrombosis can become a key factor in the development of complications with existing plaques, which can become a source of distal embolism.

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“…Клинические закономерности, полученные в данной работе, также были подтверждены экспериментальным исследованием с использованием разработанного и запатентованного нами «Устройства для моделирования внутриартериального кровообращения» [19]. Эта полезная модель позволила нам, имитируя распространение пульсовых волн при ЭС в артериальном сосуде, визуализировать и выразить в числовом выражении гемодинамические параметры при различных вариантах ЭС.…”

Section: Discussionunclassified

“…При этом на этапе обследования у этой категории больных были исключены общеизвестные факторы риска развития инсультов. В ряде зарубежных работ отмечается более высокая частота встречаемости инсультов у пациентов, имеющих частую ЭС [14][15][16][17][18][19]. Однако до сих пор ЭС не включена в перечень факторов риска артериальных тромбоэмболических событий.…”

Section: Introductionunclassified

Extrasystoles: relationship with arterial thromboembolic complications

Germanova

Germanov

Shchukin

2022

Science and Innovations in Medicine

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Aim to determine the relationship between extrasystoles (ES) and the development of arterial thromboembolic complications. Material and methods. The study included 440 patients with ES 700 or more per 24 hours, control group 88 people with ES less than 700. All patients underwent laboratory and instrumental examinations: lipid spectrum, hemostasis indicators; 24-hours ECG monitoring; echocardiography (EchoCG); Doppler ultrasound and digital sphygmography (SG) of the main arteries; ultrasound of the aorta branches, renal arteries. According to the indications, the patients were administered: stress EchoCG with physical exercises, coronary angiography, pancerebral angiography, renal arteries angiography, computed tomography, magnetic resonance imaging of the brain. All patients of the main group were divided into 2 subgroups, depending on the moment of occurrence of ES ventricular systole in the cardiocycle, regardless of the ectopic center: subgroup A (120) patients with ES before the peak of transmitral blood flow; subgroup B (320) after the peak of the transmitral blood flow. Patients were observed during 1 year and the development of arterial thromboembolic events was analyzed. Results. According to the main clinical, laboratory and instrumental data, patients of subgroups A, B and the control group were equivalent. Also, during 1 year follow-up, a significantly higher development of arterial thromboembolic events was observed in subgroup A. When comparing the linear blood flow velocity and volumetric blood flow, there was a significant increase in parameters during the spreading of the first post-extrasystolic contraction wave. A similar trend was observed in the parameters of the kinetics of the arterial vascular wall (velocity, acceleration, power, work). Conclusion. Extrasystoles are an additional risk factor for arterial thromboembolic events. The main danger is not the ES itself, but the wave of the first post-extrasystolic contraction, which can become the starting point for the instability of atherosclerotic plaques, leading to tears, parietal thrombosis, and embolism along the arterial vessel.

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Device for modeling of intra-arterial circulation: application in experimental cardiology

Cited by 5 publications

References 0 publications

Premature Ventricular Contractions as an Additional Risk Factor for the Arterial Thromboembolism

Premature Ventricular Contractions as an Additional Risk Factor for the Arterial Thromboembolism

Maximum time between cardiac cycles in atrial fibrillation for assessing the risk of arterial thromboembolism

Extrasystoles: relationship with arterial thromboembolic complications

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