1999
DOI: 10.1080/109158199225477 View full text |Buy / Rent full text
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Abstract: 4-(2,4-Dichlorophenoxy)butyric acid (2,4-DB) is principallyused in the USA on peanuts, soybeans, and alfalfa. The developmental toxicity in rats (25/group) was studied at dose levels of 0, 31.25, 62.5, and 125 mg/kg/day. The maximum tolerated dose (MTD) was clearly exceeded at 125 mg/kg/day, as evidenced by a net weight loss in the dams during the dosing period, resulting in four dams totally resorbing their fetuses.The no-observed-effectlevel (NOEL) for maternal toxicity was 31.25 mg/kg/day based on a slight,… Show more

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