Developmental Toxicity Evaluation of Methyl Tertiary-butyl Ether (MTBE) by Inhalation in Mice and Rabbits

Toxicity assessment of dimethyl carbonate following 28 days repeated inhalation exposure

“…DMC has low acute oral toxicity (LD 50 rat = 12,900 mg/kg, LD 50 mouse = 6000 mg/kg), and was found to be negative in mutagenicity tests (I.e., Ames and Comet analysis in vitro) performed on L-929 mouse fibroblasts [ 9 ]. As a result of a developmental toxicity test conducted by inhalation exposure of DMC to the mated female mice at a concentration of up to 3000 ppm per day for 6 hours, weight loss, growth retardation, and deformity of the mater and fetus were observed, so NOAEL (No Observed Adverse Effect Level) was confirmed as 1000 ppm [ 10 , 11 ]. This was almost the same as methanol (NOAEL 1000 ppm), a major metabolite of DMC [ 12 ].…”

Toxicology and Biodegradability of Tier Three Gasoline Blendstocks: Literature Review of Available Data

“…Upon completion of the testing, EPA did not ban the use of MTBE in gasoline, although many states did (EPA undated). Results of the Enforceable Consent Agreement testing have been published (Bevan et al 1997a;Bevan et al 1997b;Bird et al 1997;Daughtrey et al 1997;Lington et al 1997;McKee et al 1990;Miller et al 1997).…”