Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex

Itami, Chiaki; Huang, Jui-Yen; Yamasaki, Miwako; Watanabe, Masahiko; Lu, Hui-Chen; Kimura, Fumitaka

doi:10.1523/jneurosci.4280-15.2016

Cited by 22 publications

(36 citation statements)

References 56 publications

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“…This developmental change in the STDP rule may contribute to reorganization of thalamocortical and intracortical circuits (Itami & Kimura, ). Interestingly, the switch of STDP is associated with the developmental appearance of thalamus‐L2/3 synapses expressing cannabinoid type 1 receptor (Itami et al., ). It has been also suggested that GABAergic interneurons may control STDP rules and that GABA acts as switch of Hebbian synaptic plasticity (Paille et al., ).…”

Section: Discussionmentioning

confidence: 99%

Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex

Bourg

Yang

Stüttgen

et al. 2019

Eur J of Neuroscience

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Rhythmic whisking behavior in rodents fully develops during a critical period about 2 weeks after birth, in parallel with the maturation of other sensory modalities and the onset of exploratory locomotion. How whisker‐related sensory processing develops during this period in the primary somatosensory cortex (S1) remains poorly understood. Here, we characterized neuronal activity evoked by single‐ or dual‐whisker stimulation patterns in developing S1, before, during and after the occurrence of active whisking. Employing multi‐electrode recordings in all layers of barrel cortex in urethane‐anesthetized mice, we find layer‐specific changes in multi‐unit activity for principal and neighboring barrel columns. While whisker stimulation evoked similar early responses (0–50 ms post‐stimulus) across development, the late response (50–150 ms post‐stimulus) decreased in all layers with age. Furthermore, peak onset times and the duration of the late response decreased in all layers across age groups. Responses to paired‐pulse stimulation showed increases in spiking precision and in paired‐pulse ratios in all cortical layers during development. Sequential activation of two neighboring whiskers with varying stimulus intervals evoked distinct response profiles in the activated barrel columns, depending on the direction and temporal separation of the stimuli. In conclusion, our findings indicate that the temporal sharpening of sensory‐evoked activity coincides with the onset of active whisking.

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Section: Discussionmentioning

confidence: 99%

Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex

Bourg

Yang

Stüttgen

et al. 2019

Eur J of Neuroscience

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“…It remains unknown how LTP of the postsynapse is conveyed to the presynaptic terminal to elicit structural changes [36]. Retrograde messengers like nitric oxide, arachidonic acid, and eCBs may act as one potential mechanism of pre-post coordination of structural plasticity [37, 38]. …”

Section: Structural Changesmentioning

confidence: 99%

Closing the gap: long-term presynaptic plasticity in brain function and disease

Monday

Castillo

2017

Current Opinion in Neurobiology

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Synaptic plasticity is critical for experience-dependent adjustments of brain function. While most research has focused on the mechanisms that underlie postsynaptic forms of plasticity, comparatively little is known about how neurotransmitter release is altered in a long-term manner. Emerging research suggests that many of the features of canonical “postsynaptic” plasticity, such as associativity, structural changes and bidirectionality, also characterize long-term presynaptic plasticity. Research over the past few years has demonstrated that presynaptic plasticity is a potent regulator of circuit output and function. Moreover, aberrant presynaptic plasticity is a convergent factor of synaptopathies like schizophrenia, addiction, and Autism Spectrum Disorders, and may be a potential target for treatment.

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“…Illustration adapted from Itami et al . () with modifications. [Colour figure can be viewed at wileyonlinelibrary.com].…”

Section: Resultsmentioning

confidence: 80%

“…This pairing stimulation consistently resulted in t‐LTD (Fig. B), which was also consistent with our previous study (Itami et al ., ). As a whole, EPSPs decreased to 75.1 ± 7.4% of baseline as summarized in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Concurrently induced plasticity due to convergence of distinct forms of spike timing‐dependent plasticity in the developing barrel cortex

Itami

Kimura

2016

Eur J of Neuroscience

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Spike timing-dependent plasticity (STDP) has been demonstrated in a variety of neural circuits. Recent studies reveal that it plays a fundamental role in the formation and remodeling of neuronal circuits. We show here an interaction of two distinct forms of STDP in the mouse barrel cortex causing concurrent, plastic changes, potentially a novel mechanism underlying network remodeling. We previously demonstrated that during the second postnatal week, when layer four (L4) cells are forming synapses onto L2/3 cells, L4-L2/3 synapses exhibit STDP with only long-term potentiation (t-LTP). We also showed that at the same developmental stage, thalamus-L2/3 synapses express functional cannabinoid type 1 receptor (CB1R) and exhibit CB1R-dependent STDP with only long-term depression (t-LTD). Thus, distinct forms of STDP with opposite directions (potentiation vs. depression) converge in the target layer of L2/3 during the second postnatal week. As the canonical target layer of the thalamus is L4 and thalamic cells activate both L4 and L2/3 cells, in principle, thalamic activity could induce t-LTP at L4-L2/3 and t-LTD at thalamus-L2/3 simultaneously. In this study, we tested this possibility. We found that when spike timing stimulation was applied to the thalamus and L2/3 cells, synapses between the thalamus and L2/3 were weakened, whereas synapses between L4 and L2/3 were potentiated; therefore, converging STDP caused the predicted concurrent plasticity. We propose that developmentally transient convergences of STDP may play a role in shaping neural networks by facilitating L4-L2/3 formation and weakening aberrant thalamic innervation to L2/3, both driven by thalamic activity.

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Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex

Cited by 22 publications

References 56 publications

Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex

Temporal refinement of sensory‐evoked activity across layers in developing mouse barrel cortex

Closing the gap: long-term presynaptic plasticity in brain function and disease

Concurrently induced plasticity due to convergence of distinct forms of spike timing‐dependent plasticity in the developing barrel cortex

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