J. Neurosci. Res. volume 86, issue 3, P537-543 2008 DOI: 10.1002/jnr.21521 View full text
|
|
Share
Hedi Liu, Qichen Hu, Amanda Kaufman, A. Joseph D'Ercole, Ping Ye

Abstract: AbstractRecent studies indicate that neural cell development in the central nervous system (CNS) correlates with a reduction in acetylation of histone core proteins. Moreover, histone hypoacetylation is thought to be important to oligodendrocyte lineage development. The mechanisms mediating the reduction in acetylation during postnatal neural development remain to be defined. To begin to understand these mechanisms, we investigated the expression of histone deacetylase 11 (HDAC11), a newly identified HDAC, in…

expand abstract