2020
DOI: 10.1007/s11357-020-00175-3
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Abstract: Increased availability of cannabis and cannabinoid-containing products necessitates the need for an understanding of how these substances influence aging. In this study, zebrafish (Danio rerio) were exposed to different concentrations of THC (0.08, 0.4, 2 μM) during embryonic-larval development and the effects on aging were measured 30 months later and in the offspring of the exposed fish (F1 generation). Exposure to 0.08 μM THC resulted in increased male survival at 30 months of age. As the concentration of T… Show more

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Cited by 12 publications
(15 citation statements)
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“…Indeed, while high doses of THC can cause memory deficits [ 41 ], low doses of THC have been shown to slow or halt Alzheimer’s disease (AD) progression by reducing the amyloid beta, which is the main component of the amyloid plaques found in the brains of people affected by AD [ 42 , 43 ], and to restore cognitive function in old mice [ 44 ]. Taken together, these findings reinforce the suggestion that the THC doses and patient age determine the beneficial versus detrimental effects of THC on neuronal health [ 27 ]. Moreover, the dose seems to influence the resultant behavioral phenotype, as low doses may induce anxiolytic effects, whereas high THC doses generally cause the opposite responses [ 45 ].…”
Section: Introductionsupporting
confidence: 84%
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“…Indeed, while high doses of THC can cause memory deficits [ 41 ], low doses of THC have been shown to slow or halt Alzheimer’s disease (AD) progression by reducing the amyloid beta, which is the main component of the amyloid plaques found in the brains of people affected by AD [ 42 , 43 ], and to restore cognitive function in old mice [ 44 ]. Taken together, these findings reinforce the suggestion that the THC doses and patient age determine the beneficial versus detrimental effects of THC on neuronal health [ 27 ]. Moreover, the dose seems to influence the resultant behavioral phenotype, as low doses may induce anxiolytic effects, whereas high THC doses generally cause the opposite responses [ 45 ].…”
Section: Introductionsupporting
confidence: 84%
“…Zebrafish treated with WIN55,212-2 at 0.5 and 1 μg/mL showed no activity, even in darkness, whereas this was lethal if applied at 10 μg/mL [ 111 ]. Chronic early-life treatment with THC (0.6 mg/L) did not affect the locomotor abilities in 30-month-old zebrafish, which suggests that this psychoactive cannabinoid has no long-term effects on swimming behavior if used at low doses [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
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“…A further survey of the literature for the purpose of this study revealed ample evidence suggestive of hormesis for numerous aquatic organisms and various pollutants and emerging contaminants in dozens of publications, of which only a few selected examples are cited here (older examples can also be traced in the therein references). These examples include a plethora of species, such as of algae (microphytes) [38][39][40][41][42][43][44][45][46][47][48][49] , aquatic flowering plants [50] , organism-attached biofilms [51] , crustaceans [52][53][54][55][56][57] , cyanobacteria [49,[58][59][60][61] , fishes [62][63][64][65][66][67][68][69] , macrophytes [70][71][72][73][74][75] , marine polychaete [76] , mollusks (e.g., clams and mussels) [77,78] , periphyton [79] , phytoplankton [80] , sea anemones [81,82] , and snails [83] . Responses suggestive of hormesis were found for molecular (molecules...…”
mentioning
confidence: 99%