Abstract:BackgroundPerchlorate is an environmental contaminant that blocks iodine uptake into the thyroid gland and reduces thyroid hormones. This action of perchlorate raises significant concern over its effects on brain development.ObjectivesThe purpose of this study was to evaluate neurologic function in rats after developmental exposure to perchlorate.MethodsPregnant rats were exposed to 0, 30, 300, or 1,000 ppm perchlorate in drinking water from gestational day 6 until weaning. Adult male offspring were evaluated … Show more
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