Developmental effects in Japanese medaka (Oryzias latipes) exposed to nonylphenol ethoxylates and their degradation products

Balch, Gordon C.; Metcalfe, Chris D.

doi:10.1016/j.chemosphere.2005.02.100

Cited by 54 publications

(48 citation statements)

References 13 publications

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“…The increased sensitivity to NP in reproduction, VTG induction, and lethal toxicity in F1 could be explained in 2 ways: full-life exposure and maternal transfer. As suggested by Seki et al [17] and Balch and Metcalfe [43], long-term exposure covering a more sensitive life stage, the early developmental stage from the fertilized egg stage, led to VTG induction, skewing of secondary sex characteristics in a female direction, and gonadal intersex (testis-ova) at rates comparable to those in the present study: 11.6 and 30 mg/L (8.7 mg/L in measured), respectively. In the full-life cycle test of linear NP using the same strain of medaka [18], 51.5 mg/L linear NP exposure of the first generation from the fertilized egg stage led to disappearance of the male phenotype and inability to produce the second generation.…”

Section: Increased Sensitivity In F1 Compared With F0supporting

confidence: 88%

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Medaka extended one‐generation reproduction test evaluating 4‐nonylphenol

Watanabe

Horie

Takanobu

et al. 2017

Enviro Toxic and Chemistry

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The medaka extended one-generation test (MEOGRT) was developed as a multigenerational toxicity test for chemicals, particularly endocrine-disrupting chemicals. Briefly, 3 generations of Japanese medaka (Oryzias latipes) are exposed to a chemical over a 20-wk period: 3 wk in the parental generation (F0), 15 wk in the first generation (F1), and 2 wk in the second generation (F2). The present study reports the first MEOGRT results concerning branched isomer mixtures of 4-nonylphenol (NP). Adult F0 medaka exposed to NP at 5 actual concentrations (1.27, 2.95, 9.81, 27.8, 89.4 µg/L) were unaffected in terms of reproduction, although vitellogenin in the male liver was increased dose-dependently at concentration of 2.95 µg/L and higher. In F1, in contrast, total egg (fecundity), fertile egg, and fertility decreased as NP increased; lowest-observed-effect concentrations (LOECs) for total egg, fertile egg, and fertility were 1.27, 1.27, 27.8 µg/L, respectively. In F1, but not in F0, secondary sex characteristics (i.e., anal fin papillae in males) were suppressed at 27.8 µg/L NP. Vitellogenin induction in adult male fish was slightly weaker in F1 than it was in F0, however. Gonadal sex abnormality and sex reversal occurred at 27.8 and 89.4 µg/L NP in F1 subadults. At 89.4 µg/L NP, all genotypic F1 males in breeding pairs had female phenotype, and some even demonstrated spawning. Concentrations of NP lower than 89.4 µg/L did not affect F2 survival or hatching. The highest detected NP level in environmental freshwater in Japan was approximately a half of the LOEC (1.27 µg/L for F1 fecundity); in other countries, however, environmental concentrations above the LOEC are reported, suggesting that NP may be affecting fish populations. Environ Toxicol Chem 2017;36:3254-3266. © 2017 SETAC.

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Section: Increased Sensitivity In F1 Compared With F0supporting

confidence: 88%

“…As anal fin papillae rarely disappear once they have developed [41], reduction of anal fin papillae was only observed in the F1 generation exposed to NP from oocyte development. Balch and Metcalfe [43] also demonstrated mixed secondary sex characteristics in medaka after 100-d NP exposure from hatching.…”

Section: Increased Sensitivity In F1 Compared With F0mentioning

confidence: 89%

Medaka extended one‐generation reproduction test evaluating 4‐nonylphenol

Watanabe

Horie

Takanobu

et al. 2017

Enviro Toxic and Chemistry

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“…Transcription of gonadotropin-releasing hormone receptor mRNA in the hermaphroditic fish Kryptolebias marmoratus was up-regulated following 4-t-octylphenol exposure but was inconsistent following 4-nonylphenol exposure (both at 300 ug/L for 96 h) [48]. Impairments in gonadal differentiation and development have been reported following aqueous exposure for the hermaphrotidic fish Rivulus marmoratus to nonylphenol at 150 mg/L and 300 mg/L [49]; for Cichlasoma dimerus to 4-t-octylphenol at 300 mg/L for 60 d [50]; and for Japanese medaka (O. latipes) to nonylphenol (29 mg/L) and nonylphenol ethoxylate mixtures (105 mg/L) for 100 d [36]. Exposure of carp (Cyprinus carpio) gonad microsomes to 1 mM 4-nonylphenol significantly affected both synthesis and metabolism of sex steroids [32].…”

Section: Discussionmentioning

confidence: 99%

Altered levels of endocrine biomarkers in juvenile barramundi (Lates calcarifer; Bloch) following exposure to commercial herbicide and surfactant formulations

Kroon

Hook

Metcalfe

et al. 2015

Enviro Toxic and Chemistry

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Agricultural pesticides that are known endocrine disrupting chemicals have been detected in waters in the Great Barrier Reef catchment and lagoon. Altered transcription levels of liver vitellogenin (vtg) have been documented in wild populations of 2 Great Barrier Reef fisheries species and were strongly associated with pesticide-containing runoff from sugarcane plantations. The present study examined endocrine and physiological biomarkers in juvenile barramundi (Lates calcarifer) exposed to environmentally relevant concentrations of commercial herbicide (ATRADEX(®) WG Herbicide, DIUREX(®) WG Herbicide) and surfactant (ACTIVATOR(®) 90) formulations commonly used on sugarcane in the Great Barrier Reef catchment. Estrogenic biomarkers (namely, liver vtg messenger RNA and plasma 17β-estradiol) increased following exposure to commercial mixtures but not to the analytical grade chemical, suggesting an estrogenic response to the additives. In contrast, brain aromatase (cyp19a1b) transcription levels, plasma testosterone and 11-ketotestosterone concentrations, and gill ventilation rates were not affected by any of the experimental exposures. These findings support the assertion that exposure to pesticide-containing runoff from sugarcane plantations is a potential causative agent of altered liver vtg transcription levels in wild barramundi. Whether exposure patterns in the Great Barrier Reef catchment and lagoon are sufficient to impair fish sexual and reproductive development and ultimately influence fish population dynamics remains to be determined. These findings highlight the need to consider both active and so-called inert ingredients in commercial pesticide formulations for environmental risk assessments.

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“…And they are suspected of being responsible for an increase in the disruption of the normal physiological functions of the endocrine systems of mammals, fish, birds, reptiles and invertebrates (Golden et al, 1998;Tyler et al, 1998). These chemicals include: natural estrogens, such as 17β-estradiol and estrone; synthetic estrogens, such as 17α-ethinylestradiol; as well as xeno-estrogens, such as alkylphenols (including nonylphenol and octylphenol) and Bisphenol A (Gray and Metcalfe, 1997;Staples et al, 1998;Hasselberg et al, 2004;Balch and Metcalfe, 2006). Also some persistent organochlorine pesticides (DDT derivatives, such as o, p′-DDT) have been proved to have estrogenic potency (Gaido et al, 1997;Soto et al, 1995;Bonefeld-Jorgensen et al, 2005;Greenlee et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Measurement of estrogenic activity in sediments from Haihe and Dagu River, China

Song

Jiang

et al. 2006

Environment International

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Sediments from two rivers in China, the Haihe and Dagu Rivers, were examined for estrogenic activity using an estrogen receptor (ER)-mediated in vitro bioassay system. ER-active compounds were isolated from sediments by Soxhlet extraction, and the crude extracts were fractionated using a florisil column into three fractions. The estrogenic activity of each extract was detected by measuring luciferase activity in the human breast cancer cell line MCF-7 transfected with a luciferase receptor gene. Significant estrogenic activity was observed in each total extract. The 17β-estradiol equivalents (E2-EQs) ranged from 8.24 to 95.28 ng E2 g − 1 dw. As a result, the relative estrogenic potencies of three fractions in this study descended in the order of Fraction 3 N Fraction 2 N Fraction 1. The results of the bioassay analysis indicated the heavy pollution status of these sites with estrogenic contaminants. In this study, five selected chemicals, the natural estrogens 17β-estradiol (E2) and estrone (E1), and the xeno-estrogens 4-octylphenol (OP), 4-nonylphenol (NP), and Bisphenol A (BPA) were also analyzed using the in vitro bioassay. The estrogenic activity of these chemicals were E2 N E1 N NP N OP N BPA.

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Developmental effects in Japanese medaka (Oryzias latipes) exposed to nonylphenol ethoxylates and their degradation products

Cited by 54 publications

References 13 publications

Medaka extended one‐generation reproduction test evaluating 4‐nonylphenol

Medaka extended one‐generation reproduction test evaluating 4‐nonylphenol

Altered levels of endocrine biomarkers in juvenile barramundi (Lates calcarifer; Bloch) following exposure to commercial herbicide and surfactant formulations

Measurement of estrogenic activity in sediments from Haihe and Dagu River, China

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