Developmental delay in P300 production in children at high risk for developing alcohol-related disorders

Hill, Shirley Y.; Shen, Sa; Locke, Jeannette; Steinhauer, Stuart R.; Konicky, Colleen; Lowers, Lisa; Connolly, John F.

doi:10.1016/s0006-3223(99)00032-3

Cited by 115 publications

(147 citation statements)

References 55 publications

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“…This finding appears to be most strongly related to age (younger children/adolescents in contrast to adults), gender (boys have lower P300 than girls) and the density of alcoholism cases within the family. Our longitudinal follow-up of the same children at yearly intervals shows that developmental trajectories of P300 amplitude differ between risk groups [Hill et al, 1999c] and variation in trajectory pattern may be associated with risk for developing a childhood or adolescent psychiatric disorder [Hill and Shen, 2002]. An association between P300 amplitude at age 10 and later development of alcohol problems was seen in 18 year olds in our laboratory [Hill et al, 1995c].…”

Section: Discussionmentioning

confidence: 67%

A genome wide search for alcoholism susceptibility genes

Hill

Shen

Zezza

et al. 2004

American J of Med Genetics Pt B

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115

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Alcoholism is currently one of the most serious public health problems in the US. Lifetime prevalence rates are relatively high with one in five men and one in 12 women meeting criteria for this condition. Identification of genetic loci conferring an increased susceptibility to developing alcohol dependence could strengthen prevention efforts by informing individuals of their risk before abusive drinking ensues. Families identified through a double proband methodology have provided an exceptional opportunity for gene-finding because of the increased recurrence risks seen in these sibships. A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4 cM and genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17.

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Section: Discussionmentioning

confidence: 67%

A genome wide search for alcoholism susceptibility genes

Hill

Shen

Zezza

et al. 2004

American J of Med Genetics Pt B

Self Cite

115

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“…This relationship is modulated by biological factors (Polich and Kok, 1995), differences among paradigms (DiTraglia and Polich, 1991;Stenberg, 1994), and psychopathology (Iacono et al, 2002(Iacono et al, , 2003Justus et al, 2001). These effects could be related to individual differences for attentional resource capabilities that may stem from variability for neurotransmitter function (Hill et al, 1998(Hill et al, , 1999Polich and Criado, 2006).…”

Section: Applied P300 Characteristicsmentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

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The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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“…Alternatively, the differences may arise due to altered topography of the cognitive potentials in younger versus the older subjects. Moreover, Hill et al (1999)also report gender differences in the P3 growth trajectories. They observe lower starting amplitudes and a slower decrease in visual P3 amplitudes with age in high risk boys and a faster growth rate and higher amplitudes of P3 in high risk girls in contrast to the respective low risk groups.…”

Section: P300 Amplitude Changesmentioning

confidence: 95%

“…However, with more difficult visual paradigms the effect sizes for the two age groups converged. Hill and colleagues in their studies on developmental patterns of P300 in children and adolescents postulated that a developmental delay resulted in the lowered amplitudes of P300 seen in high risk children (Hill et al, 1999). The authors also suggested that the visual P3 amplitudes had a 'theoretical point of convergence' around the age of 22 for high risk and low risk subjects.…”

Section: P300 Amplitude Changesmentioning

confidence: 99%

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

117

136

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Background-Visual P300 is consistently lower in alcohol dependent individuals, their offspring and subjects at risk. Delta and theta event related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 millisecond post-stimulus window (corresponding to the zone of P3 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers.Methods-EEG was recorded during the performance of visual oddball task. The S-Transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitudes for the target.Results-The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group.Conclusions-The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

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Developmental delay in P300 production in children at high risk for developing alcohol-related disorders

Cited by 115 publications

References 55 publications

A genome wide search for alcoholism susceptibility genes

A genome wide search for alcoholism susceptibility genes

Updating P300: An integrative theory of P3a and P3b

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

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