Development of Thrombosis Models in the Rabbit

Stepnick, David W.; Hayden, Richard E.; Hogikyan, Norman D.

doi:10.1001/archotol.1994.01880330075014

Cited by 26 publications

(32 citation statements)

References 12 publications

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“…The purpose of our study was to investigate the potential benefit of topically applied recombinant human tissue factor pathway inhibitor (rhTFPI) on venous anastomses. To test this, the rat venous tuck model was utilized as described by Stepnick et al and others 7–9. Rates of patency versus a control were compared.…”

Section: Introductionmentioning

confidence: 99%

Seasonal patterns of birth for subjects with bulimia nervosa, binge eating, and purging: Results from the National Women's Study

Brewerton

Dansky

O’Neil

et al. 2011

Intl J Eating Disorders

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Section: Introductionmentioning

confidence: 99%

Seasonal patterns of birth for subjects with bulimia nervosa, binge eating, and purging: Results from the National Women's Study

Brewerton

Dansky

O’Neil

et al. 2011

Intl J Eating Disorders

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“…For the poor suture technique used for microsurgical anastomosis, we modified an inverting suture technique previously described by other groups, that applied an inverting suture over half the circumference of the common iliac artery. 3,8,10,12 That previously described technique provides a continuous thrombogenic stimulus, because intravascular blood flow is exposed to adventitia containing thrombogenic collagen, and it has been shown to cause microembolization of distal tissues at the microcirculatory level. 8,10 Our present study is a first setting for evaluating the long-term effect of poor suture technique, as a modification of the previously described technique, at the level of the main supply artery by monitoring peripheral tissue perfusion distal to the anastomotic site.…”

Section: Discussionmentioning

confidence: 99%

“…Other groups described an inverting suture over half the circumference of the common iliac artery. 3,8,10,12 That suture technique provided a continuous thrombogenic stimulus due to intravascular blood flow exposed to adventitia containing thrombogenic collagen. This previous suture technique was shown to cause microembolization of distal tissues at the microcirculatory level.…”

Section: Experimental Groupsmentioning

confidence: 99%

“…2À5,8,9 Short-term effects on skeletal muscle microcirculation, with acute decreases in capillary perfusion, have been demonstrated using various models, including an inverting arterial suture model. 10 However, it is not known if the decrease in tissue perfusion is only temporary, or if this is a long-lasting effect. If there is persistent patency of the sutured feeding artery, autogenous fibrinolysis should be sufficient to maintain long-term tissue perfusion at the microcirculatory level.…”

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confidence: 99%

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Impact of poor microsurgical suture technique on tissue perfusion in a rat model

et al. 2003

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This study was designed to evaluate the effect of poor suture technique in microsurgical small-vessel anastomosis on tissue microcirculation. Eighteen male Sprague-Dawley rats were divided into three groups of six animals each: sham control group, regular suture group (control), and inverting suture group. In the regular suture group, a standard single-stitch suture technique was used for microsurgical reanastomosis of the transected common iliac artery. In the inverting suture group, a suture technique was applied inverting the vessel wall, thus simulating poor suture technique. After 24 h, intravital microcirculatory measurements were obtained in the cremaster muscle flap. The inverting suture caused a significant drop in capillary perfusion from 6.40 (sham control) and 5.65 (regular suture) to 1.81 capillaries per visual field (P < 0.005). A poor microsurgical anastomosis may result in a significant reduction of peripheral tissue perfusion, although blood flow through the main feeding vessel is maintained.

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“…1,2,5 This effect has been shown in experimental thrombosis models. 6 However, it is not known if an arterial crush injury may decrease tissue perfusion at the microcirculatory level by dislodging microthrombi downstream into the microvascular bed.…”

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confidence: 99%

Arterial crush injury causes decrease in tissue perfusion at the level of the microcirculation in skeletal muscle flap

et al. 1999

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This study was designed to evaluate the effects of crush injuries to the feeding arteries of a muscle flap on microcirculatory haemodynamics. Eighteen male Sprague-Dawley rats were divided into three experimental groups for intravital microscopy of the cremaster muscle flap. Group 1 served as control. In group 2 the common iliac artery and in group 3 additionally the lower abdominal aorta was crushed with a Kocher clamp (17.4 N) over 5 min. Microcirculatory parameters (red blood cell velocity, vessel diameter, and capillary perfusion) were monitored before and 2 h after crush. In the one-level crush group, red blood cell velocities significantly decreased by 39.17% (P=0.046) in first order arterioles and by 32. 91% (P=0.0106) in second order arterioles. In capillary perfusion, a drop of 48.02% (P=0.0039) was noted. In the two-level crush group, red blood cell velocities significantly dropped over 32.06% (P=0. 0250) in first order arterioles, 35.91% (P=0.0065) in second order arterioles, and 45.69% (P=0.0782) in first order venules. Capillary perfusion was reduced by 20.16% (P=0.374). Arterial crush injuries as possible thrombogenic insults may result in a significant decrease in skeletal muscle perfusion although the blood supply through the crushed supplying vessel is maintained.

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Development of Thrombosis Models in the Rabbit

Cited by 26 publications

References 12 publications

Seasonal patterns of birth for subjects with bulimia nervosa, binge eating, and purging: Results from the National Women's Study

Seasonal patterns of birth for subjects with bulimia nervosa, binge eating, and purging: Results from the National Women's Study

Impact of poor microsurgical suture technique on tissue perfusion in a rat model

Arterial crush injury causes decrease in tissue perfusion at the level of the microcirculation in skeletal muscle flap

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