Development of the neurocranium after transsutural fixing by new, resorbable poly-L-lactide miniplates. a comparison to fixing with the common titanium miniplates

Antikainen, T.; Pernu, Hannu; Törmälä, P.; Kallioinen, Matti; Waris, Timo; Serlo, Willy

doi:10.1007/bf01400649

Cited by 16 publications

(3 citation statements)

References 21 publications

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“…This continuous decrease in integrity could anyway be positive in some applications, e.g. in bioabsorbable devices for cranial growth in children (Antikainen et al ., ), where compensatory bone lengthening (normalizing bone response) may take place, leading to a maintained overall skeletal morphology (Eppley and Sadove, ). For these purposes, more rapidly degrading materials, such as PLGA, are preferred because they soften with time and allow for device elongation without interfering with bone regrowth (Eppley and Sadove, ).…”

Section: Synthetic Polymersmentioning

confidence: 99%

Polymeric scaffolds as stem cell carriers in bone repair

Rossi

Santoro

Perale

2013

J Tissue Eng Regen Med

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Although bone has a high potential to regenerate itself after damage and injury, the efficacious repair of large bone defects resulting from resection, trauma or non-union fractures still requires the implantation of bone grafts. Materials science, in conjunction with biotechnology, can satisfy these needs by developing artificial bones, synthetic substitutes and organ implants. In particular, recent advances in polymer science have provided several innovations, underlying the increasing importance of macromolecules in this field. To address the increasing need for improved bone substitutes, tissue engineering seeks to create synthetic, three-dimensional scaffolds made from polymeric materials, incorporating stem cells and growth factors, to induce new bone tissue formation. Polymeric materials have shown a great affinity for cell transplantation and differentiation and, moreover, their structure can be tuned in order to maintain an adequate mechanical resistance and contemporarily be fully bioresorbable. This review emphasizes recent progress in polymer science that allows relaible polymeric scaffolds to be synthesized for stem cell growth in bone regeneration.

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Section: Synthetic Polymersmentioning

confidence: 99%

Polymeric scaffolds as stem cell carriers in bone repair

Rossi

Santoro

Perale

2013

J Tissue Eng Regen Med

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“…It avoids the unwanted effects of metallic implants in the skull [13] as it does not interfere with modern neuro-imaging. The results of careful experimental studies have shown that fixation with thin self-reinforced poly-L-lactide (SR-PLLA), like poly-L-lactide (PLLA) miniplates can be achieved in the cranium without any adverse effects such as delayed union or inflammatory or clinically manifested foreign-body reactions [1,7,8,9]. Successful clinical results were reported by Fuente del Campo et al [3], who operated on 32 patients, fixing their maxillary osteotomies with SR-PLLA plates.…”

Section: Introductionmentioning

confidence: 99%

A new technique for correction of trigonocephaly in an infant: application of an absorbable endocranial plate

Serlo

Ashammakhi²,

Törmälä

et al. 2000

Child's Nerv Syst

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We report on a new method of cranial bone osteofixation using absorbable material, which is applied endocranially to avoid the application of a thick, cosmetically inferior system epicranially in the frontal area. This is especially important in the correction of deformity in trigonocephaly cases. A 9-month-old boy presented with a prominent trigonocephalic deformity. Cranioplasty was performed, in which a supraorbital bar (bandeau) was removed, reinforced with a self-reinforced polylactide (SR-PLA) plate and reshaped to correct the deformity. The plate was applied on the inner side of the bony bar, with its ends fixed epicranially to the temporal bones by means of SR-PLA miniscrews. 3-D CT scans and rapid prototypes were used to evaluate the results. Stable and secure fixation was obtained, and the cosmetic result appeared excellent. No complications occurred during the postoperative period of 1 year. Hence, stabilisation of cranial bone can be achieved endocranially using an absorbable plate and screws, with an encouraging cosmetic result. The method is thought to be reliable.

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“…[ 7 8 9 ] However, in certain newborn rabbits, it was identified that placing even resorbable hardware could cause local asymmetry during the growth phase, which later was reversible. [ 10 ] All these studies involved critical areas such as coronal, frontal, or sagittal sutures. There are very less human studies in this aspect.…”

Section: Discussionmentioning

confidence: 99%

Rigid versus Resorbable Plate Fixation in Fronto-Orbital Advancement in Unicoronal Stenosis - A Retrospective Study

Balaji¹,

Balaji²

2022

Annals of Maxillofacial Surgery

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Introduction: Rigid plating fixation (RPF) and resorbable plating systems (RPS) advanced the field of reconstruction in craniomaxillofacial region. However, their performance in patients, particularly the effect on bone remodeling at site of hardware placement is not much documented. This manuscript aims to compare the performance of RPF and RPS in a cohort using a retrospective audit of case records. Methods: Archival records were searched for patients who had undergone cranial metal-RPF or RPS or combination for the correction of craniofacial deformities following inclusion-exclusion criteria. From records, data of the quality and quantity of bone formed along the site of plate fixation as compared with the adjacent site, accommodating or facilitating brain growth, and persistence of bone deformity at the site of hardware placement were collected at the end of the follow-up period. A total of 128 sites from 18 individuals (6 with exclusive metal-RPF and 12 with RPS) mean age of 7.45 ± 7.28 (Median 4; IQR of 8.88;2.6–11.5) who underwent cranial bone remodeling surgery formed the study group. Results: There was a statistically significant difference between the RPF and PRS system at the fronto-orbital suture ( P = 0.002) and coronal suture ( P = 0.036) with bone quality and quantity. Discussion: The RPF system was rigid but had a set of issues, while RPS has advantages and limitations. The qualitative difference in between the two systems is different. Due to inherent dissimilarity, the two systems cannot be interchanged and due diligence has to be exercised while deciding on the system. More prospective studies are needed to validate the findings.

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Development of the neurocranium after transsutural fixing by new, resorbable poly-L-lactide miniplates. a comparison to fixing with the common titanium miniplates

Cited by 16 publications

References 21 publications

Polymeric scaffolds as stem cell carriers in bone repair

Polymeric scaffolds as stem cell carriers in bone repair

A new technique for correction of trigonocephaly in an infant: application of an absorbable endocranial plate

Rigid versus Resorbable Plate Fixation in Fronto-Orbital Advancement in Unicoronal Stenosis - A Retrospective Study

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