Development of systemic sarcoidosis and xanthoma planum during multiple sclerosis treatment with interferon‐beta 1a: Case Report

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

“…This hypothesis is further supported by the observed development of sarcoid-like granulomatous disease in patients administered IFN-α, e.g. as a treatment for hepatitis C infection [94][95][96]. Conversely, the same phenomenon has been reported repeatedly in patients receiving anti-CTLA-4 or anti-PD-1 therapy (e.g.…”

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

“…This hypothesis is further supported by the observed development of sarcoid-like granulomatous disease in patients administered IFN-α, e.g. as a treatment for hepatitis C infection [94][95][96]. Conversely, the same phenomenon has been reported repeatedly in patients receiving anti-CTLA-4 or anti-PD-1 therapy (e.g.…”

Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

“…We reviewed 24 case reports (27 cases) of IFN-α-induced sarcoidosis (Table 1 ) [ 5 – 28 ] and 6 case reports (6 cases) of IFN-β-induced sarcoidosis (Table 2 ) [ 29 – 34 ] that were published between January 2009 and November 2018. All the cases were diagnosed based on histological evaluation.…”

Advance in pathogenesis of sarcoidosis: Triggers and progression

“…In recent years, several reports suggested that patients treated with drugs such as interferon-α (IFN-α), immune checkpoint inhibitors, and BRAF inhibitors may develop sarcoidosis as a result of drug effects [ [67] , [68] , [69] , [70] , [71] , [72] ]. Investigators observed that the histopathologic features of nodular granulomas in these treated patients were consistent with sarcoidosis granulomas which provided clinical evidence for drug antigens.…”

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

“…This hypothesis is further supported by the observed development of sarcoid-like granulomatous disease in patients administered IFN-α, e.g. as a treatment for hepatitis C infection [94][95][96]. Conversely, the same phenomenon has been reported repeatedly in patients receiving anti-CTLA-4 or anti-PD-1 therapy (e.g.…”

Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

“…We reviewed 24 case reports (27 cases) of IFN-α-induced sarcoidosis (Table 1 ) [ 5 – 28 ] and 6 case reports (6 cases) of IFN-β-induced sarcoidosis (Table 2 ) [ 29 – 34 ] that were published between January 2009 and November 2018. All the cases were diagnosed based on histological evaluation.…”

Advance in pathogenesis of sarcoidosis: Triggers and progression

“…In recent years, several reports suggested that patients treated with drugs such as interferon-α (IFN-α), immune checkpoint inhibitors, and BRAF inhibitors may develop sarcoidosis as a result of drug effects [ [67] , [68] , [69] , [70] , [71] , [72] ]. Investigators observed that the histopathologic features of nodular granulomas in these treated patients were consistent with sarcoidosis granulomas which provided clinical evidence for drug antigens.…”

Moving target: shifting the focus to pulmonary sarcoidosis as an autoimmune spectrum disorder

“…This hypothesis is further supported by the observed development of sarcoid-like granulomatous disease in patients administered IFN-α, e.g. as a treatment for hepatitis C infection [94][95][96]. Conversely, the same phenomenon has been reported repeatedly in patients receiving anti-CTLA-4 or anti-PD-1 therapy (e.g.…”

Interferon-induced sarcoidosis with uveitis as the initial symptom: a case report and review of the literature

“…We reviewed 24 case reports (27 cases) of IFN-α-induced sarcoidosis (Table 1 ) [ 5 – 28 ] and 6 case reports (6 cases) of IFN-β-induced sarcoidosis (Table 2 ) [ 29 – 34 ] that were published between January 2009 and November 2018. All the cases were diagnosed based on histological evaluation.…”

Advance in pathogenesis of sarcoidosis: Triggers and progression

“…In recent years, several reports suggested that patients treated with drugs such as interferon-α (IFN-α), immune checkpoint inhibitors, and BRAF inhibitors may develop sarcoidosis as a result of drug effects [ [67] , [68] , [69] , [70] , [71] , [72] ]. Investigators observed that the histopathologic features of nodular granulomas in these treated patients were consistent with sarcoidosis granulomas which provided clinical evidence for drug antigens.…”