Development of sucrose stearate-based nanoemulsions and optimisation through γ-cyclodextrin

Klang, Victoria; Matsko, Nadejda B.; Raupach, Karoline; El-Hagin, Nivine; Valenta, Claudia

doi:10.1016/j.ejpb.2011.01.010

Cited by 62 publications

(34 citation statements)

References 41 publications

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“…However, polyethoxylated surfactants are sometimes viewed critically regarding their skin compatibility (Bergh et al, 1998). Thus, we attempted to partially replace the ethoxylated surfactant by the biodegradable and eudermic surfactant sucrose stearate (Klang et al, 2011a). A combination of Solutol HS 15 and the sugar surfactant S1670 (13 + 2) was found to lead to satisfying results.…”

Section: Nanoemulsion Characterisationmentioning

confidence: 98%

“…In recent years, a large number of studies has dealt with the optimisation of oil-in-water emulsions with particle sizes in the lower submicron range (Yilmaz and Borchert, 2005;Hoeller et al, 2009;Klang et al, 2011a). These systems, conveniently termed "nanoemulsions", are aimed at topical drug delivery or cosmetic applications on skin (Klang et al, 2011b;Patravale and Mandawgade, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

Schwarz

Klang

Karall

et al. 2012

International Journal of Pharmaceutics

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Section: Nanoemulsion Characterisationmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

Schwarz

Klang

Karall

et al. 2012

International Journal of Pharmaceutics

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“…21,22) These reports have shown that CDs may have a stabilizing effect on nanoemulsions including stabilizing zeta potential values. It is most likely that the CDs are incorporated into the interfacial film around the oil droplets.…”

Section: Fig 7 Cytotoxic Effects Of Lutein Loaded Vehicles On Rgc Cmentioning

confidence: 99%

“…19,20) For example, the addition of γCD in lipid emulsions enhances the transdermal delivery of steroidal drugs such as progesterone 21) and fludrocortisone. 22) However, the studies combining CD and nanoemulsions for ophthalmic formulations are rare according to our literature survey. Ocular drug delivery is one of the most challenging fields because of the critical and specific environment of the eyes.…”

Section: )mentioning

confidence: 99%

“…The mixed interfacial films are more flexible and thus more suitable to form stable droplets. 21,22) The proposed mechanism for HEβCD that enhancing the scleral accumulation of lutien was due to the enhanced stability on the nanoemulsions. Nevertheless further investigation shall be performed to confirm the speculation.…”

Section: Fig 7 Cytotoxic Effects Of Lutein Loaded Vehicles On Rgc Cmentioning

confidence: 99%

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<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Liu

Lai

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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Lutein is a macular pigment that contributes to maintaining eye health. The development of luteinladen nanocarriers for ocular delivery would have the advantages of user friendliness and cost-effectiveness. Nano-scaled vehicles such as cyclodextrin (CD) and nanoemulsion could overcome the barriers caused by the scleral structure. This study focused on the development of hybrid nanocarriers containing nanoemulsion and CD for scleral lutein accumulation. In the presence of the nanoemulsion, CD forms such as βCD and hydroxyethyl (HE) βCD increased the partition of lutein into the porcine sclera. A combination of nanoemulsion and 2% HEβCD enhanced lutein accumulation to 119 6 µg g 1 h 1 , which was 9.2-fold higher than that with lutein suspension alone. We explored the dose effect of CD in nanoemulsion on scleral lutein and found that the scleral accumulation of lutein was enhanced by increasing the CD content. The novel nanoemulsion had 95% drug-loading efficiency and low cytotoxicity in retinal cells. The CD-modified nanoemulsion not only improved the stability and entrapment efficacy of lutein in the aqueous system but also enhanced scleral lutein accumulation. An increase in the partition coefficient of lutein in porcine sclera when using the CDmodified nanoemulsion was also confirmed.

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Current challenges ahead in preparation, characterization, and pharmaceutical applications of nanoemulsions

Yousefpoor,

Esnaashari,

Baharifar

et al. 2023

WIREs Nanomed Nanobiotechnol

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Nanoemulsions (NEs) are emulsions with particle size of less than around 100 nm. Reviewing the literature, several reports are available on NEs, including preparation, characterization, and applications of them. This review aims to brief challenges that researchers or formulators may encounter when working with NEs. For instance, when selecting NE components and identifying their concentrations, stability and safety of the preparation should be evaluated. When preparing an NE, issues over scale‐up of the preparation as well as possible effects of the preparation process on the active ingredient need to be considered. When characterizing the NEs, the two major concerns are accuracy of the method and accessibility of the characterizing instrument. Also a highly efficient NE for clinical use to deliver the active ingredient to the target tissue with maximum safety profile is commonly sought. Throughout the review we also have tried to suggest approaches to overcome the challenges.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Development of sucrose stearate-based nanoemulsions and optimisation through γ-cyclodextrin

Cited by 62 publications

References 41 publications

Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Current challenges ahead in preparation, characterization, and pharmaceutical applications of nanoemulsions

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