Development of single-phase silver-doped antibacterial CDHA coatings on Ti6Al4V with sustained release

Sikder, Prabaha; Koju, Naresh; Ren, Yufu; Goel, Vijay K.; Phares, Tamara L.; Lin, Boren; Bhaduri, Sarit B.

doi:10.1016/j.surfcoat.2018.02.100

Cited by 42 publications

(31 citation statements)

References 44 publications

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“…As a result, their initial structure and permeability got disrupted, thus resulting in death (Jung et al, ). Our group as well as Xu et al have studied the effect of Ag + on the morphology of such bacterial strains and have reported similar results (Sikder, Grice, et al, ; Sikder, Koju, et al, ; Xu et al, ).…”

Section: Discussionsupporting

confidence: 73%

“…Lim et al, in a recent review, focused on the fact that Ag‐doped HA (Ag‐HA) composites resulted in an uncontrolled release of Ag + release resulting in potential cytotoxicity (Lim, Chang, & San, ). This has been our experience with Ag‐doped coatings as well (Sikder, Koju, et al, ; Sikder, Grice, et al, ).…”

Section: Discussionmentioning

confidence: 72%

“…Contemporary research has taken advantage of these properties and has used Ag nanoparticles (Ag‐NP) or Ag + ions in various innovative forms, thereby opening up a whole new arena to inhibit SSI in implants (Lu et al, ; Xu et al, ). For instance, our group recently fabricated Ag‐doped calcium deficient‐hydroxyapatite (CD‐HA) coatings which prove to be active antibacterial agents against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ; Sikder et al, ). Thus, Ag when used either intrinsically or incorporated into another material matrix like HA, can exhibit useful antibacterial properties without inducing cytotoxicity (Lu et al, ; Surmeneva et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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This article reports for the first time our successful result in the synthesis of antibacterial single‐phase newberyite (NB, MgHPO4.3H2O), an important magnesium phosphate (MgP) bioceramic. The prime novelty lies in the fact that we explore novel MgPs as next‐generation orthopedic biomaterials as opposed to conventional calcium phosphates (CaP). While NB has already shown great promise, unlike its competitor struvite (ST, MgNH4PO4.6H2O), NB is not intrinsically antibacterial. Given the havoc created by surgical site infections (SSI) in orthopedics, it would be worthwhile to explore if antibacterial NB can be synthesized cost‐effectively. To accomplish that central goal, we used silver ion (Ag+) containing precursor solutions and exposed those to microwave irradiation. This action resulted in the rapid synthesis of NB microplatelets. Besides, three other specific objectives are addressed. First, Ag‐doping was optimized to preserve the single‐phase nature for sustained dopant release. Second, Ag+ release kinetics against common infection causing bacterial strains was analyzed. Finally, we inspected for any harmful effect of Ag‐doped NB on MC3T3 preosteoblasts. Interestingly, the single‐phase nature of NB microplatelets can be retained until 2 wt % Ag‐doping and they exhibit good antibacterial and cytocompatible properties. Even though 3 wt % Ag‐doped compositions (composites) were 100% antibacterial; they were cytotoxic.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

et al. 2019

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“…The growth of the Gram-positive bacterium was higher in comparison with the Gram-negative bacteria, because the bacterium Bacillus licheniformis has a thicker peptidoglycan layer in its membrane, which regulates and prevents the path of AgNPs in low concentrations to the cell as indicated by Mathew T. et al [4]. Similar results with a difference in antibacterial activity were observed by Sikder et al [62,63] when exploring antibacterial surfaces on PEEK and Ti6Al4V, and such studies were performed in the case of Gram-negative (E. coli) and gram-positive (S. aureus) bacteria. Apart from the difference in the diameter of inhibition zone, their research also presented SEM images which prove the variance in interactions of Ag + ions with negative and positive strains of bacteria.…”

Section: Antibacterial Testsupporting

confidence: 54%

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

et al. 2019

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The coating of polymeric substrate polyetheretherketone (PEEK) with silver nanoparticles (AgNPs) was carried out by a wet chemical route at room temperature. The coating process was developed from the Tollens reagent and D-glucose as reducing agent. The resulting composite exhibited antimicrobial activity. The PEEK films were coated with a single layer and two layers of silver nanoparticles in various concentrations. The crystallographic properties of the polymer and the silver nanoparticles were analyzed by X-ray diffraction (XRD). Fourier transform infrared spectra (FTIR) show the interaction between the silver nanoparticles with the polymeric substrate. Transmission electron microscope (TEM) images confirmed the obtaining of metallic nanoparticles with average sizes of 25 nm. It was possible to estimate the amount of silver deposited on PEEK with the help of thermogravimetric analysis. The morphology and shape of the AgNPs uniformly deposited on the PEEK films was ascertained by the techniques of scanning electron microscopy (SEM) and atomic force microscopy (AFM), evidencing the increase in the amount of silver by increasing the concentration of the metal precursor. Finally, the antibacterial activity of the films coated with Ag in Escherichia coli, Serratia marcescens and Bacillus licheniformis was evaluated, evidencing that the concentration of silver is crucial in the cellular replication of the bacteria.

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“…Ag-doped calcium deficient dydroxyapatite coated titanium [178] E coli 5 , Sa 6 showed antibacterial effect and sustained release over 14 days…”

Section: Coating Type Anti-bacterial Experiments Model * Resultsmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Development of single-phase silver-doped antibacterial CDHA coatings on Ti6Al4V with sustained release

Cited by 42 publications

References 44 publications

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

Silver (Ag) doped magnesium phosphate microplatelets as next‐generation antibacterial orthopedic biomaterials

Coating of Polyetheretherketone Films with Silver Nanoparticles by a Simple Chemical Reduction Method and Their Antibacterial Activity

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

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