Development of simple drift tube design for ion mobility spectrometry based on flexible printed circuit board material

Chantipmanee, Nattapong; Hauser, Peter C.

doi:10.1016/j.aca.2021.338626

Cited by 15 publications

(31 citation statements)

References 21 publications

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“…Tetrabutylammonium (T4) was to be used as an internal standard for quantification, and at 5 μM, it gave a single peak at 19.8 ms. This corresponds to a reduced mobility in nitrogen of 1.24 cm 2 V −1 s −1 , which is very close to the value of 1.25 cm 2 V −1 s −1 reported previously by our group for a different instrument [ 12 ] and within the range from 1.19 to 1.42 cm 2 V −1 s −1 found by Fernandez-Maestre in a literature survey [ 37 ]. As can also be seen from Fig.…”

Section: Resultssupporting

confidence: 90%

“…The instrument is based on the design reported by Reineke and Clowers and on our earlier implementation [ 2 , 12 ]. A schematic diagram of the instrument and its periphery is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…However, alternative ionization methods are possible in the form of corona discharges [ 5 , 6 ], UV-ionization [ 7 , 8 ], or low-temperature plasmas [ 9 – 11 ]. Electrospray ionization, as a further option, has the advantage of being suitable for liquid samples containing non-volatile species [ 2 , 12 ]. The study reported herein is a contribution to the exploration of the scope of potential applications of an in-house constructed IMS instrument with electrospray ionization.…”

Section: Introductionmentioning

confidence: 99%

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Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

Chantipmanee,

Hauser

2022

Anal Bioanal Chem

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The analysis of tobramycin was demonstrated successfully as an example for electrospray ionization on an open-source hardware ion mobility spectrometer. This instrument was assembled inexpensively in-house, and required only very few purpose-made components. The quantitative determination of tobramycin required 20 s for a reading. The calibration curve for the range from 50 to 200 μM was found to be linear with a correlation coefficient of r = 0.9994. A good reproducibility was obtained (3% relative standard deviation) and the limit of detection was determined as 8 μM. As the concentration of the active ingredient in the eye drops (ophthalmic solutions) is too high for the sensitivity of the instrument, the samples had to be diluted appropriately. Graphical abstract

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Section: Resultssupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

Chantipmanee,

Hauser

2022

Anal Bioanal Chem

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“…Ion-mobility spectrome-try can be used in conjunction with mass spectrometry to improve the specificity of the system. [96][97][98] Consequently, the combination with nanofluidic devices will allow for further improvement in specificity. Moreover, tandem mass spectrometry is another method used to enhance specificity.…”

Section: High Level Of Specificity and Selectivitymentioning

confidence: 99%

“…In particular, target analytes are present in complex biological samples. Ion‐mobility spectrometry can be used in conjunction with mass spectrometry to improve the specificity of the system 96‐98 . Consequently, the combination with nanofluidic devices will allow for further improvement in specificity.…”

Section: Perspectivesmentioning

confidence: 99%

Toward nanofluidics‐based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds

Chantipmanee¹,

2022

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Exploring unknown matter in an ultrasmall volume object, such as unknown subcellular matter in a single cell, requires an analytical technique that identifies unknown matter in terms of molecular structures and properties. Mass spectrometry is considered one of the best techniques for such analyses because it can identify unknown matter according to its mass‐to‐charge ratio. However, the use of mass spectrometry to identify unknown substances in such a small world has been greatly impeded due to the lack of tools to sample complex and heterogeneous analytes with ultrasmall volumes of the picoliter order, which is the volume order of a mammalian cell. We believe that nanofluidics would be an ideal tool to resolve this critical issue owing to its ability to sample such fluid samples with ultrasmall volumes ranging from the picoliter to zeptoliter order. Thus, the integration of such nanofluidic features into mass spectrometers would open up future avenues for the potential of mass spectrometry to explore unknown subcellular matter at a nano scale. In this perspective, we first discuss the applicability of microfluidics/nanofluidics to mass spectrometry, then address critical issues toward nanofluidics‐based mass spectrometry, and finally depict a personal outlook on the future of this field to resolve challenges on global and universal scales.

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A portable wireless‐sensor system from all‐in‐one sensor array based hybrid solid contact layer for point‐of‐care ion monitoring in river basin

et al. 2023

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The sensor arrays are considered as a promising way to aim at point-of-care (POC) testing for the detection of different ions in environment through the use of solid-contact ion-selective electrodes (SC-ISEs). However, the exorbitant equipment and intricate process for the production of SC-ISEs arrays has limit its application. Herein, the Au with nano-branched structure (Au NBS) and poly (3,4-ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT : PSS) were decorated on the surface of bare pad of traditional printed circuit boards coated with Au (Au-PCB) to construct a hybrid solid-contact layer including double-layer capacitance and pseudocapacitance of SC-ISEs synergistically, thus the multichannel SC-ISEs exhibited high stability and specificity. Overall, based on portable multichannel sensor and homemade APP (Ion Analysis), a wireless all-in-one sensor system was constructed to detect ions with the limit of NO 3 À , Cl À , Na + , K + , Ca 2 + and Mg 2 + as 0.047 mM, 0.039 mM, 0.022 mM, 0.066 mM, 0.045 mM and 0.024 mM, respectively. Besides, it can detect such ions in river basin successfully. With the cost of each electrode less than 0.5 $, this sensor arrays enable a wide range of hazardous ion monitoring in water environment. K E Y W O R D Sall-in-one electrode, ions, point-of-care testing, river basin, solid contact layer

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Development of simple drift tube design for ion mobility spectrometry based on flexible printed circuit board material

Cited by 15 publications

References 21 publications

Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

Toward nanofluidics‐based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds

A portable wireless‐sensor system from all‐in‐one sensor array based hybrid solid contact layer for point‐of‐care ion monitoring in river basin

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