Intern. Med. volume 35, issue 8, P660-662 1996 DOI: 10.2169/internalmedicine.35.660 View full text
Ken SATOH, Ikuo MIURA, Akihiko CHUBACHI, Seiko UTSUMI, Hirokazu IMAI, Akira B. MIURA

Abstract: A 42-year-old womanwith Crow-Fukase syndrome developed acute myeloid leukemia (M6: FABclassification)following treatment with alkylating agents (a total of2,500 mg ofmelphalan and 9,800 mg of cyclophosphamide). Chromosome analysis of the bone marrow showed 49,XX,der(l;7)(qlO;plO), +8, +19, +21 in therapy-related myelodysplastic syndrome with additional chromosomes 8, and 12 and two additional chromosomes 21 in acute leukemia. Because of the risk of therapy-related leukemia, alkylating agents should be used wi…

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