Development of pH-sensitive and antibacterial gelatin/citric acid/Ag nanocomposite hydrogels with potential for biomedical applications

Shafagh, Nima; Sabzi, Mohammad; Afshari, Mehdi

doi:10.1007/s10965-018-1661-9

Cited by 41 publications

(19 citation statements)

References 46 publications

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“…Saito et al reported the use of a citric acid derivative, obtained through the modification of citric acid carboxyl groups with N-hydroxysuccinimide in presence of 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide hydrochloride, for the preparation of crosslinked type A porcine skin gelatin gels [25]. More recently, Shafagh et al reported the use of citric acid to crosslink porcine skin gelatin in presence of Ag nanoparticles to produce, through a green approach in which water was used as a solvent, gelatin/Ag nanocomposite hydrogels with swelling and a drug release behavior both depending on pH [26]. Uranga et al developed citric acid-crosslinked fish gelatin films, starting from an aqueous solution containing also glycerol and chitosan, with potentials for packaging applications since the presence of citric acid in the films did not produce any change of color, but improved both the light barrier and mechanical properties of the obtained films [27].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of Fish Gelatin Solution Containing Citric Acid: An Environmentally Friendly Approach to Prepare Crosslinked Gelatin Fibers

et al. 2019

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The majority of the crosslinking approaches employed to confer water resistance properties to electrospun gelatin mats are based on the use of potential cytotoxic agents, turning out to be not suitable for biomedical applications. Environmentally friendly chemical strategies based on the use of non-toxic agents are, therefore, strongly demanded. In the present work, the possibility to produce crosslinked electrospun fish gelatin mats by electrospinning an aqueous solution, containing citric acid as a crosslinking agent, is reported. The effect of pH on solution rheological properties, as well as on the electrospun mat morphology, chemistry, and crosslinking degree, is assessed. The increase of solution pH from 1.8 to 3.7 allows for obtaining fibers that maintain the fibrous morphology also in the mat. Subsequent thermal treatment of the electrospun mat (80 °C for 30 min) turns out to increase the crosslinking degree and morphological stability of the mat.

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Section: Introductionmentioning

confidence: 99%

Electrospinning of Fish Gelatin Solution Containing Citric Acid: An Environmentally Friendly Approach to Prepare Crosslinked Gelatin Fibers

et al. 2019

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“…The FTIR spectra of neat GE, GE/sepiolite (GE1‐Sep1) nanocomposite, and as‐received sepiolite powder are presented in Figure . The typical absorption bond of GE located at 1663 cm −1 is assigned to the carbonyl stretching vibration of Amide I . Amide II of GE exhibited the bending vibration of NH groups at 1544 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

“…Recently, several attempts have been made to composite the adsorbents with biopolymers, such as poly(vinyl alcohol), carrageenan, chitosan, alginate, cellulose, and silk fibroin which led to enhancement in their adsorption capacity. Gelatin (GE) is a natural biopolymer and has a long history of safe use in cosmetic, pharmaceutical and food industries . Surprisingly, to date, the application of GE for water treatment is rare in the literature, likely due to its insufficient stability and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Assembly of gelatin biopolymer to fibrous sepiolite clay for efficient dye removal from wastewater

Sabzi

Shafagh

Mohammadi

2019

J of Applied Polymer Sci

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This work aimed to fabricate nanocomposites using low‐cost and natural materials for fast and efficient dye adsorption from wastewater. To achieve this, fibrous sepiolite clay was incorporated into the gelatin (GE) biopolymer. The obtained nanocomposites were characterized by Fourier transform infrared spectroscopy and scanning electron microscope techniques. The effects of sepiolite/GE ratio, adsorbent dosage, solution pH, contact time, and initial dye concentration on the adsorption capacity of nanocomposites were well studied and optimized through batch adsorption study. Kinetics, isotherms, and thermodynamics analysis were also performed for methylene blue adsorption. The adsorption data were better fitted with the pseudo‐second‐order and Langmuir isotherm models. The prepared nanocomposites demonstrated a fast and efficient adsorption performance toward the MB dye with the maximum adsorption capacity as high as 684.8 mg g−1 within only an equilibrium time of 30 min, which revealed their promising potential in wastewater treatment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48266.

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“…The most commonly used metals are silver (Ag) and zinc oxide (ZnO) NPs, because these two metals can directly enter the bacterial cells to bind the DNA or oxidative metabolic enzymes, leading to hinder the bacteria metabolism or mutate the DNA. Both the hydrogels are good bactericidal materials against E. coli and S. aureus ( Shafagh et al, 2018 ; Neacsu et al, 2019 ). Crosslinked carboxymethyl chitosan (CMCh)/ZnO hydrogel, produced from in situ formation of ZnO nanorods in the crosslinked carboxymethyl chitosan (CMCh) matrix, is effective against E. coli and S. aureus ( Wahid et al, 2015 ).…”

Section: Classification and Properties Of Antibacterial Materialsmentioning

confidence: 99%

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Qiu

Luo

et al. 2020

Front. Bioeng. Biotechnol.

119

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Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients’ health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infection treatment. Therefore, it is urgent to develop new antibacterial drugs to meet clinical or civilian needs. Antibacterial polymers have attracted the interests of researchers due to their unique bactericidal mechanism and excellent antibacterial effect. This article reviews the mechanism and advantages of antimicrobial polymers and the consideration for their translation. Their applications and advances in medical device surface coating were also reviewed. The information will provide a valuable reference to design and develop antibacterial devices that are resistant to pathogenic infections.

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Development of pH-sensitive and antibacterial gelatin/citric acid/Ag nanocomposite hydrogels with potential for biomedical applications

Cited by 41 publications

References 46 publications

Electrospinning of Fish Gelatin Solution Containing Citric Acid: An Environmentally Friendly Approach to Prepare Crosslinked Gelatin Fibers

Electrospinning of Fish Gelatin Solution Containing Citric Acid: An Environmentally Friendly Approach to Prepare Crosslinked Gelatin Fibers

Assembly of gelatin biopolymer to fibrous sepiolite clay for efficient dye removal from wastewater

The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

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