Development of pH-responsive poly(γ-cyclodextrin) derivative nanoparticles

Oh, Nam Muk; Oh, Kyung Taek; Lee, Eun Seong

doi:10.1016/j.colsurfb.2014.04.017

Cited by 14 publications

(39 citation statements)

References 31 publications

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“…To prepare pH‐responsive nanogels, the starch (PEG x /DEAP y ) (10 mg) was dissolved in DMSO (15 mL) containing DTX (2 mg). The solution was dialyzed (Spectra/Por MWCO 15 kDa) against PBS/sodium tetraborate buffer (145/5 mM, pH 7.4) for 1 day and then lyophilized . In addition, the pH‐nonresponsive nanogels were prepared using the starch (PEG 0.25 /DOCA 0.30 ) by the same procedure as described above.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we developed pH‐responsive polysaccharidic nanogels using starch grafted with polyethylene glycol (PEG, to improve the stability of nanogels in body) and 3‐(diethylamino)propylamine (DEAP, to provide pH‐responsive properties to nanogels), hereafter denoted as starch (PEG/DEAP). Here, we utilized the nonprotonation/protonation properties of DEAP moieties (pK b ~ pH 7.0) depending on pH . The nonprotonated DEAP moieties at pH 7.4 can enhance the loading efficiency of a model antitumor drug (docetaxel [DTX]) when the lipophilicity of the soft starch core is increased, whereas the protonated DEAP moieties at pH 6.5 cause ion‐dipole interactions with hydroxyl groups rich in starch backbone.…”

Section: Introductionmentioning

confidence: 99%

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pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

Noh

Lim

Lee

2019

Polymers for Advanced Techs

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In this study, we report pH-responsive polysaccharidic nanogels comprising starch grafted with 3-(diethylamino)propylamine (DEAP, as an inner soft nanogel core) and poly(ethylene glycol) (PEG, as an outer hydrophilic nanogel shell). Here, the DEAP moieties (pK b~p H 7.0) enhance the lipophilicity of the nanogel core at pH 7.4, improving the loading efficiency of an antitumor model drug (docetaxel [DTX]) in the core. However, the DEAP moieties could be protonated below pH 7.0, resulting in the mediation of ion-dipole interactions with hydroxyl groups abundant in starch backbone. This event causes the electrostatic condensation of the nanogel core and enables the acceleration of drug release by squeezing of the core. We demonstrated that the nanogels selectively release the drug given a weakly acidic pH stimulus. These drug release trends are reversible with changes in pH. As a result, the nanogels are able to efficiently reduce MDA-MB-231 tumor cell population in acidic pH environments.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

Noh

Lim

Lee

2019

Polymers for Advanced Techs

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“…The cells were washed with a fresh RPMI‐1640 medium 3 times and incubated for an additional 12 hours. Cell viability was determined using a Cell Counting Kit‐8 …”

Section: Methodsmentioning

confidence: 99%

“…In contrast, natural particle‐forming polysaccharides are expected to enable a safe and useful strategy for drug delivery via introduction of functional groups. It is known that starch is easily eliminated from the human body and readily forms as microparticles that tend to stay where they are injected . These characteristics are beneficial to implant applications.…”

Section: Introductionmentioning

confidence: 99%

pH‐responsive starch microparticles for a tumor‐targeting implant

Kim¹,

Park

Lee

et al. 2018

Polymers for Advanced Techs

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Much progress has been made toward stimuli-responsive polysaccharide-based selective tumor therapy not only because polysaccharides have nontoxic biodegradability and biocompatibility but also because their stimuli-sensitive characteristics enable the proper transport of payloads into tumors. Here, we attempted to deliver an antitumor drug, doxorubicin (DOX), using starchbased microparticles coupled with pH-responsive 3-(diethylamino)propylamine. The microparticles of starch conjugated with 3-(diethylamino)propylamine (SDEAP) allowed for the change in hydrophobicity of SDEAPs in a pH-dependent manner. The results revealed that SDEAPs effectively carried and released DOX and selectively killed tumor cells under acidic condition. Overall, this study suggests that DOX-loaded SDEAPs can be further explored as a strategy for applications to acidic tumor-targeting implants owing to the drug-deliver efficiency and tumor selectivity.

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“…[47][48][49][50] In parallel, the synthesis of CD-polymers (poly-CDs) has been developed to a large extent with the purpose of combining the advantages of the polymers (high molecular weight and targeting capability) with the ability of CD to form inclusion complexes 51 (Fig.1). Most of the publications deal with 30 the synthesis of βCD-polymers since βCD interacts with the widest range of drugs, 11,52-55 but recent research has focused on γCD-and αCD-polymers due the appropriated cavity size of γCD to host large molecules, [56][57][58] and the ability of poly-αCD to tread along PEO chain forming syringeable gels. 59 35 Fig.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular cyclodextrin-based drug nanocarriers

2015

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Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances. CDs can perform as multifunctionalizable cores to which very diverse (macro)molecules and drugs can be conjugated. Grafting with amphiphilic molecules can lead to nanoassemblies exhibiting a variety of architectures. CDs can also polymerize with other CDs or can be used to functionalize preexisting polymers to form polymers/networks with enhanced capability to form inclusion complexes. Alternatively, CDs can be exploited as transient cross-linkers to form poly(pseudo)rotaxane-based networks or zipper-like assemblies. Combination of mutifunctionality and complexation ability of CDs has been shown to be useful to develop depot-like formulations and colloidal nanocarriers with improved performances regarding easiness of administration, protection of the encapsulated substances, control of the delivery rate, and cell interactions. The aim of this review is to provide an overall view of the diversity of designs of CD-based supramolecular nanosystems with a special focus on the advances materialized in the last five years, including clinical trials.

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Development of pH-responsive poly(γ-cyclodextrin) derivative nanoparticles

Cited by 14 publications

References 31 publications

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

pH‐responsive squeezing polysaccharidic nanogels for efficient docetaxel delivery

pH‐responsive starch microparticles for a tumor‐targeting implant

Supramolecular cyclodextrin-based drug nanocarriers

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