Development of novel alginate based hydrogel films for wound healing applications

Pereira, Rúben F.; Carvalho, Anabela; Vaz, Daniela C.; Gil, M.H.; Mendes, Ausenda; Bartolo, Paulo Jorge Da Silva

doi:10.1016/j.ijbiomac.2012.09.031

Cited by 366 publications

(212 citation statements)

References 45 publications

(89 reference statements)

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“…In addition, the increase in the alginate proportion caused an increase in the percentages of solid remains. This may be due to the duration of alginate in water rather longer than CMC and the formation of crosslink between Cu 2+ and carboxylate group occurring only in alginate portion [8]. …”

Section: Percentages Of Solid Remainmentioning

confidence: 99%

Alginate/Carboxymethyl Cellulose Hydrogel Films in Relation to Crosslinking with Glutaraldehyde and Copper Sulfate

Sritweesinsub

Charuchinda

2015

MATEC Web of Conferences

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Abstract. Alginate/carboxymethyl cellulose (CMC) hydrogel films using glutaraldehyde (GA) and/or copper sulfate (Cu 2+ ) as crosslinking agents were prepared. The ratios of alginate to CMC were varied at 0:10, 2:8, 4:6, 6:4, 8:2 and 10:0 in the presence of GA at 0, 2, 5% and/or copper sulfate of 0 and 0.02 mol. The Fourier Transform Infrared Spectroscopy (FTIR) spectra of hydrogels indicated the intermolecular interaction between CMC with GA and alginate with Cu 2+ . Using a couple of GA and Cu 2+ , as crosslinking agents, the hydrogels exhibited better swelling time than that of a crosslinking agent alone. The percentages of solid remains were increased by increasing both of alginate ratio and Cu 2+ content.

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Section: Percentages Of Solid Remainmentioning

confidence: 99%

Alginate/Carboxymethyl Cellulose Hydrogel Films in Relation to Crosslinking with Glutaraldehyde and Copper Sulfate

Sritweesinsub

Charuchinda

2015

MATEC Web of Conferences

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“…Due to their high water absorption rates, adhesion to the wound bed and increased pain during dressing changes, traditional dressings (e.g., gauze, cotton wool) are often employed as secondary dressings to allow the exudate drainage and to support the application of more effective products (e.g., skin substitutes) [77,115]. Traditional dressings have been largely replaced by modern dressings, which are capable of creating and maintaining a moist environment in the wound bed, ideally suited for cellular migration and proliferation [81,115,124,150,151]. A great deal of interest has been focused on advanced dressings with the ability to release bioactive substances directly into the wound bed [6,75,161,192].…”

Section: Therapeutic Options For Skin Reconstructionmentioning

confidence: 99%

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

et al. 2017

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Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in predefined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, preclinical results are summarized and future perspectives for the field are highlighted.

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“…The potential of chitosan in developing hydrogel-based transdermal drug delivery systems was demonstrated in several investigations. Tsai et al have successfully delivered berberine through the skin by incorporating in a hydrogel formulation for the treatment of leishmaniasis [45]. This polymer was also utilized in developing hydrogel-based matrix diffusion controlled and membrane permeation controlled transdermal systems of diltiazem.…”

Section: Hydrogels For Transdermal Delivery Of Drugsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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Development of novel alginate based hydrogel films for wound healing applications

Cited by 366 publications

References 45 publications

Alginate/Carboxymethyl Cellulose Hydrogel Films in Relation to Crosslinking with Glutaraldehyde and Copper Sulfate

Alginate/Carboxymethyl Cellulose Hydrogel Films in Relation to Crosslinking with Glutaraldehyde and Copper Sulfate

Advances in bioprinted cell-laden hydrogels for skin tissue engineering

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

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