Development of new phosphated cellulose for application as an efficient biomaterial for the incorporation/release of amitriptyline

Bezerra, Roosevelt D.S.; Morais, Alan Ícaro Sousa; Osajima, Josy A.; Nunes, Lívio César Cunha; Filho, Edson Cavalcanti da Silva

doi:10.1016/j.ijbiomac.2016.01.063

Cited by 40 publications

(23 citation statements)

References 45 publications

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“…After this point, pH = 11, the proton retention decreases. This result shows that the pH of the medium affects the surface of the CN polymer, meaning that ions in the solution (H + or OH − ) can interact with the active sites of the CN polymer, thereby changing the charge balance of this polymer [ 3 ]. This result also shows that the incorporation of amino groups, on the cellulose surface, changed the pH pzc graph of CN polymer compared to the pristine microcrystalline cellulose at different pH values.…”

Section: Resultsmentioning

confidence: 99%

“…The CN polymer presented more efficient AMI adsorption in aqueous media than unmodified polymer. A previous study showed that the maximum adsorption capacity of pristine cellulose was 20.23 ± 0.80 mg·g −1 at pH 5 and 298 K [ 3 ]. Thus, incorporation of amino groups on cellulose has promoted an increase in the maximum adsorption capacity of 206.77% (CN polymer: q e = 62.06 ± 2.10 mg·g −1 at pH 7 and 298 K).…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, the supernatant was separated by centrifugation at 3500 rpm for 15 min [ 9 ]. The drug concentration was determined for each time by UV/Vis from calibration curves at a wavelength λ = 239 nm, which corresponds to the length of maximum absorption of the drug (all the experiments were in triplicate, with limit of detection 1.0 mg L −1 ), and the amount adsorbed of the adsorbent, q (mg·g −1 ) was calculated by Equation (3) [ 3 ]:

where V (L) is the volume of the drug solution, C 0 (mg·L −1 ) is the initial concentration of the drug solution, C f (mg·L −1 ) is the concentration of the drug solution after adsorption at each time, t and m (g) the mass of the adsorbent.…”

Section: Methodsmentioning

confidence: 99%

“…Examples of drugs found in water bodies are psychiatric ones, such as anxiolytics, sedatives and antidepressants. These medications are among the most prescribed around the world, and consequently, have been frequently found in water bodies [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The extensive use of AMI has resulted in its frequent detection in wastewater, surface runoff and effluent from sewage treatment plants, and as such, these waters could potentially reach agricultural land through the application of municipal biosolids or reclaimed water use [ 4 ]. Therefore, many techniques for the removal of this contaminant from aqueous media have been studied, such as: advanced oxidation processes (UV radiation and Fenton reagent) [ 5 ], membrane bioreactors [ 6 ], distillation membranes [ 7 ], and adsorption [ 2 , 3 , 4 ], among other techniques.…”

Section: Introductionmentioning

confidence: 99%

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Direct Modification of Microcrystalline Cellulose with Ethylenediamine for Use as Adsorbent for Removal Amitriptyline Drug from Environment

Bezerra

Leal

Silva³

et al. 2017

Molecules

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Cellulose derivatives have been widely used as adsorbents for the removal of micropollutants such as drugs, dyes, and metals, due to their abundance, low cost and non-contaminating nature. In this context, several studies have been performed searching for new adsorbents (cellulose derivatives) efficient at contaminant removal from aqueous solutions. Thus, a new adsorbent was synthesized by chemical modification of cellulose with ethylenediamine in the absence of solvent and applied to the adsorption of amitriptyline (AMI) in aqueous solution. The modification reaction was confirmed by X-ray Diffraction (XRD), elemental analysis, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetry/Differential Scanning Calorimeter (TG/DSC), solid state Nuclear Magnetic Resonance of 1H and 13C (1H-NMR and 13C-NMR). Moreover, the effectiveness of reaction was confirmed by computational calculations using Density Functional Theory (DFT) at level B3LYP/6-31G(d). This adsorption process was influenced by pH, time, concentration, temperature and did not show significant changes due to the ionic strength variation. Through these experiments, it was observed that the maximum adsorption capacity of AMI by CN polymer at 298 K, 300 min, and pH 7 was 87.66 ± 0.60 mg·g−1.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Direct Modification of Microcrystalline Cellulose with Ethylenediamine for Use as Adsorbent for Removal Amitriptyline Drug from Environment

Bezerra

Leal

Silva³

et al. 2017

Molecules

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Recent Progress on Cellulose‐Based Ionic Compounds for Biomaterials

Yang

Zeng

et al. 2020

Advanced Materials

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Cellulose and hemicelluloses represent the most abundant biomaterials on the Earth and represent major structural components in cell walls of plant that provide them with sufficient mechanical Glycans play important roles in all major kingdoms of organisms, such as archea, bacteria, fungi, plants, and animals. Cellulose, the most abundant polysaccharide on the Earth, plays a predominant role for mechanical stability in plants, and finds a plethora of applications by humans. Beyond traditional use, biomedical application of cellulose becomes feasible with advances of soluble cellulose derivatives with diverse functional moieties along the backbone and modified nanocellulose with versatile functional groups on the surface due to the native features of cellulose as both cellulose chains and supramolecular ordered domains as extractable nanocellulose. With the focus on ionic cellulose-based compounds involving both these groups primarily for biomedical applications, a brief introduction about glycoscience and especially native biologically active glycosaminoglycans with specific biomedical application areas on humans is given, which inspires further development of bioactive compounds from glycans. Then, both polymeric cellulose derivatives and nanocellulose-based compounds synthesized as versatile biomaterials for a large variety of biomedical applications, such as for wound dressings, controlled release, encapsulation of cells and enzymes, and tissue engineering, are separately described, regarding the diverse routes of synthesis and the established and suggested applications for these highly interesting materials.

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