Development of innovative paclitaxel-loaded small PLGA nanoparticles: Study of their antiproliferative activity and their molecular interactions on prostatic cancer cells

Broc-Ryckewaert, Delphine Le; Carpentier, Rodolphe; Lipka, Emmanuelle; Daher, Sameh; Vaccher, Claude; Betbeder, Didier; Furman, Christophe

doi:10.1016/j.ijpharm.2013.05.018

Cited by 55 publications

(23 citation statements)

References 55 publications

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“…6B), the increased transport of FITC-DEX cannot be readily attributed to cell death (and the consequent development of ''leaky holes'' in the monolayers); increased cytotoxicity is however noticeable with high doses (4 mg/mL) at long incubation times (>72 h). While PLA-DEX nanoparticles were seen to increase the transport of FITC-DEX to some extent (possibly via non-specific nanoparticle-cell interaction) [40], data appear to support the hypothesis that the alkylglyceryl modification could possibly increase barrier permeability via mediated opening of the tight junctions. This is further supported by data from ECIS experiments, which revealed transient drops in TEER values upon the application of nanoparticles.…”

Section: Resultsmentioning

confidence: 52%

Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation

et al. 2015

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Section: Resultsmentioning

confidence: 52%

Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation

et al. 2015

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“…NPs-Aln were spherical as shown by AFM observations and demonstrated a negative zeta potential (ca. À28 mV), which can be attributed to the presence of the ionized carboxyl groups of PLGA on the particles' surface (Le Broc-Ryckewaert et al, 2013). Interestingly, unloaded nanoparticles were slightly bigger (ca.…”

Section: Properties Of Aln-loaded Plga Nanoparticlesmentioning

confidence: 98%

Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

Posadowska

Pařízek

Filová

et al. 2015

International Journal of Pharmaceutics

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“…NPs can be surface modified using targeting ligands, such as transferrin,16 hyaluronic acid,17 trastuzumab,18 and peptides,19 to improve their tumor targeting and cellular internalization.…”

Section: Introductionmentioning

confidence: 99%

Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting

Choi¹,

Park²

2016

DDDT

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The purpose of this study was to develop the surface modification of docetaxel nanocrystals (DTX-NCs) with apo-Transferrin human (Tf) for improving the cellular uptake and cytotoxicity of DTX. DTX-NCs were prepared by a nanoprecipitation method, and the surface modified with Tf by an adsorption method (Tf-DTX-NCs). The morphology and particle size of DTX-NCs and Tf-DTX-NCs were characterized using a field emission scanning electron microscope and zetasizer. An in vitro drug release study was performed in phosphate-buffered saline containing 0.5% (w/v) Tween 80 for 24 hours. Cellular uptake was studied at 0.5, 1, and 2 hours. A cytotoxicity study was performed using the A549 (human lung cancer) cell line after 24-, 48-, and 72-hour treatments. The mean sizes were 295±97 and 398±102 nm for DTX-NCs and Tf-DTX-NCs, respectively. Tf-DTX-NCs and DTX-NCs exhibited rapid drug release, whereas DTX (pure) was slowly released. Tf-DTX-NCs showed higher cellular uptake than DTX-NCs in confocal microscopic and quantitative studies. Moreover, at DTX concentration of 100 µg/mL, Tf-DTX-NCs (82.6%±0.8%) showed higher cytotoxicity than DTX-NCs (77.4%±4.1%) and DTX (pure; 20.1%±4.6%) for 72-hour treatment. In conclusion, Tf-DTX-NCs significantly improved the cellular uptake and cytotoxicity of DTX in the A549 cell line.

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Development of innovative paclitaxel-loaded small PLGA nanoparticles: Study of their antiproliferative activity and their molecular interactions on prostatic cancer cells

Cited by 55 publications

References 55 publications

Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation

Nanoparticles of alkylglyceryl-dextran-graft-poly(lactic acid) for drug delivery to the brain: Preparation and in vitro investigation

Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate

Development of docetaxel nanocrystals surface modified with transferrin for tumor targeting

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