Development of implantable catheter flow sensor into inside of bronchi for laboratory animal

Shikida, Mitsuhiro; Matsuyama, Tomohiro; Yamada, Takayuki; Matsushima, Miyoko; Kawabe, Tsutomu

doi:10.1007/s00542-015-2663-8

Cited by 10 publications

(8 citation statements)

References 13 publications

(12 reference statements)

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“…As an alternative to the angiographic study, a development of implantable sensors was conducted, targeting thrombosis diagnosis. − Several devices have been implemented in the studies for the benefit of angiography-free monitoring. , Such devices have shown promise in aortic aneurysm follow-ups without the angiographic imaging method, but they are too bulky for easy implantation in small cerebral aneurysms (diameter <7 mm) due to the electronic components. Even though recent developments show miniaturized and implantable sensors, − the overall dimension and lack of mechanical compliance prohibit intravenous, conformal deployment to the highly contoured and tapered neurovascular vessels.…”

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confidence: 99%

Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

et al. 2018

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Random weakening of an intracranial blood vessel results in abnormal blood flow into an aneurysmal sac. Recent advancements show that an implantable flow diverter, integrated with a medical stent, enables a highly effective treatment of cerebral aneurysms by guiding blood flow into the normal vessel path. None of such treatment systems, however, offers post-treatment monitoring to assess the progress of sac occlusion. Therefore, physicians rely heavily on either angiography or magnetic resonance imaging. Both methods require a dedicated facility with sophisticated equipment settings and time-consuming, cumbersome procedures. In this paper, we introduce an implantable, stretchable, nanostructured flow-sensor system for quantification of intra-aneurysmal hemodynamics. The open-mesh membrane device is capable of effective implantation in complex neurovascular vessels with extreme stretchability (500% radial stretching) and bendability (180° with 0.75 mm radius of curvature) for monitoring of the treatment progress. A collection of quantitative mechanics, fluid dynamics, and experimental studies establish the fundamental aspects of design criteria for a highly compliant, implantable device. Hemocompatibility study using fresh ovine blood captures the device feasibility for long-term insertion in a blood vessel, showing less platelet deposition compared to that in existing implantable materials. In vitro demonstrations of three types of flow sensors show quantification of intra-aneurysmal blood flow in a pig aorta and the capability of observation of aneurysm treatment with a great sensitivity (detection limit as small as 0.032 m/s). Overall, this work describes a mechanically soft flow-diverter system that offers an effective treatment of aneurysms with an active monitoring of intra-aneurysmal hemodynamics.

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confidence: 99%

Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

et al. 2018

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“…Silicon flow sensors are highly attended in development of MEMS devices, because of their simple and efficient thermal and Perspective view of an implantable catheter flow sensor with the ability to anchor onto the inside of the animal's bronchus via its legs [56]. (C) Schematic cross-section view (not to scale) of a thermoelectronic airflow sensor [60].…”

Section: Silicon-based Hot-wire/film Mems Thermal Flow Sensorsmentioning

confidence: 99%

“…Numerous miniaturized flow sensors have been developed for monitoring biomedical signals, such as blood or intraocular pressure, intravascular blood flow, aspirated-and inspired-air flow, and breathing characteristics [52][53][54][55]. In this regard, an implantable catheter flow sensor established by Shikida et al, which was specified to sense breathing parameters of animal models after anchoring in the airway by means of legs [56]. The instrument was fabricated by insertion of patterned of an Au/Cr hot-film anemometer sensor into a heat shrinkable Teflon tube.…”

Section: Metallic-based Hot-wire/film Mems Thermal Flow Sensorsmentioning

confidence: 99%

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Design and applications of MEMS flow sensors: A review

Ejeian

Azadi

Razmjou

et al. 2019

Sensors and Actuators A: Physical

274

125

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“…Various micromachined flow sensors have been developed for applications such as inspired airflow, aspirated air flow and for certain other breathing characteristics. In this regard, for the measurement of breathing characteristics, an implantable catheter flow sensor has been developed [119]. The sensor has unique legs-like structures that help it in attaching to the walls of the air passage.…”

Section: ) Mems Flow Sensorsmentioning

confidence: 99%

MEMS Sensors for Diagnostics and Treatment in the Fight Against COVID-19 and Other Pandemics

et al. 2021

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As the world is going through an existential global health crisis, i.e., the outbreak of novel coronavirus-caused respiratory disease , the healthcare systems of all the countries require readily available, low cost and highly precise equipment for the rapid diagnostics, monitoring, and treatment of the disease. The performance and precision of this equipment are solely dependent on the sensors being used. The advancement in research and development of micro-electro-mechanical systems (MEMS) based sensors during recent years, has resulted in the improvement of the conventional equipment being used in biomedical and health care applications. Microfluidics (Lab-on-a-chip) and MEMS sensors are now being used extensively for quick and accurate detection, progression monitoring, and treatment of various diseases including Covid-19. The ongoing miniaturization and design improvements have resulted in more precise sensors and actuators for healthcare applications, even for micro and nanoscale measurements in drug delivery and other invasive applications. This article aims at reviewing the MEMS sensors being used or which can be used in the important equipment for the detection and treatment of Covid-19 or other pandemics. An insight into various designs and working principles of the research-based and commercially available MEMS sensors is presented. The study highlights the role and importance of MEMS sensors in the improvement of equipment with conventional sensors. MEMS sensors outperform the conventional sensors due to their small size (1µm-1mm), negligible weight, prompt response, precise measurements, portability, and ease of integration with electronic circuitry.

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Development of implantable catheter flow sensor into inside of bronchi for laboratory animal

Cited by 10 publications

References 13 publications

Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics

Design and applications of MEMS flow sensors: A review

MEMS Sensors for Diagnostics and Treatment in the Fight Against COVID-19 and Other Pandemics

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