Development of gold(III) thiosemicarbazonate complex–loaded PLGA nanoparticles: characterization and sustained release studies

Silva, Raphael T. C.; Dalmolin, Luciana Facco; Moreto, Jéferson Aparecido; Oliveira, Carolina Gonçalves; Machado, Antônio Eduardo da Hora; Lopez, Renata Fonseca Vianna; Maia, Pedro Ivo da Silva

doi:10.1007/s11051-020-05064-6

Cited by 8 publications

(3 citation statements)

References 47 publications

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“…This might be in line with the amount of FA encapsulated which might be located at the edge of the PLGA surface facilitating the FA diffusion. 94 Other examples reported for drug-loaded PLGA NPs showing quasi-Fickian diffusion mechanisms can be found elsewhere. 95–98 A linear trend in a log–log plot of FA released versus incubation time also, confirmed this diffusion mechanism (Fig.…”

Section: Resultsmentioning

confidence: 91%

Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood–brain barrier in model membranes

et al. 2023

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Section: Resultsmentioning

confidence: 91%

Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood–brain barrier in model membranes

et al. 2023

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“…[176][177] In 2020, Silva et al developed PLGA nanoparticles as a delivery system for the gold complex, demonstrating controlled release behavior by utilizing the diffusion and relaxation properties of the polymeric matrix, with high encapsulation efficiency and stability over time. [178] In 2017, Vinuesa et al investigated the potential use of novel nanostructured formulations of benznidazole, emphasizing the potential for nanostructured formulations to improve Chagas disease treatment, but their toxicity and efficacy need careful consideration before clinical use. [179] In 2016, Scalise et al…”

Section: Nanomedicine Alternativesmentioning

confidence: 99%

“…In 2020, Silva et al . developed PLGA nanoparticles as a delivery system for the gold complex, demonstrating controlled release behavior by utilizing the diffusion and relaxation properties of the polymeric matrix, with high encapsulation efficiency and stability over time [178] . In 2017, Vinuesa et al .…”

Section: Treatmentmentioning

confidence: 99%

Alternative Approaches for the Treatment of Chagas Disease

Chaudhary,

Rajge,

Khandale

et al. 2024

ChemistrySelect

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Chagas disease (CD), or American trypanosomiasis, caused by the parasitic protozoa Trypanosoma cruzi, is a substantial global health burden. This comprehensive review explored the multifaceted landscape of CD treatment, providing a historical perspective on the development and discontinuation of benznidazole (BNZ) and nifurtimox (NF), the primary medications. Efforts towards a pediatric version of BZN in Brazil address demographic‐specific treatments, while concerns over drug resistance prompt the exploration of alternative medications like Amiodarone, Allopurinol, Posaconazole, Ravuconazole, and Fexinidazole, which were clinically tested as antichagasic drugs. In recent years, some of the synthesized derivative (1,3‐thiazoles, 4‐thiazolidinones, 2‐styrylquinolines, imidazole‐containing nitrophthalazine, and some others) were found to better activity as compared to standard drug. Traditional herbal alternatives (Resveratrol, curcumin, 1,8‐cineole, β‐pinene, and some others) rooted in traditional practices show promise, with various plant extracts exhibiting anti‐parasitic properties. The frontier of nanomedicine unfolds with studies on solid nanomedicines, PLA‐nanoparticles, ZIF‐8, BNZ carriers, and PLGA nanoparticles, showcasing improved drug delivery systems and controlled release mechanisms. The absence of a definitive vaccine accentuates ongoing research in recombinant antigens, peptide‐based vaccines, and nanoparticle formulations, with notable candidates like TcG1, TcG2, TcG4, MASPpep‐KLH, adenovirus vectors, Tc24 protein, and integrin activators. A novel strategy combining a recombinant protein vaccine with low dose BZN treatment presents promising results in a mouse model, emphasizing the urgency for further research and potential advancements in CD therapeutics.

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Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems

2023

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The discovery of the medicinal properties of gold complexes has fuelled the design and synthesis of new anticancer metallodrugs, which have received special attention due to their unique modes of action. Current research in the development of gold compounds with therapeutic properties is predominantly focused on the molecular design of drug leads with superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive research aims at improving the physicochemical properties of gold compounds, such as chemical stability and solubility in the physiological environment. In this regard, the encapsulation of gold compounds in nanocarriers or their chemical grafting onto targeted delivery vectors could lead to new nanomedicines that eventually reach clinical applications. Herein, we provide an overview of the state‐of‐the‐art progress of gold anticancer compounds, andmore importantly we thoroughly revise the development of nanoparticle‐based delivery systems for gold chemotherapeutics.

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Development of gold(III) thiosemicarbazonate complex–loaded PLGA nanoparticles: characterization and sustained release studies

Cited by 8 publications

References 47 publications

Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood–brain barrier in model membranes

Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood–brain barrier in model membranes

Alternative Approaches for the Treatment of Chagas Disease

Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems

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