2004
DOI: 10.1007/s00280-004-0881-3 View full text |Buy / Rent full text
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Abstract: Helicobacter pylori infection is associated with histological gastritis, gastric atrophy, gastric cancer and mucosa-associated lymphoid tissue lymphoma in the stomach. However, gastric cancer only develops in a minority of infected individuals. Such clinical diversity is caused by variations in the interactions between H. pylori pathogenicity, host susceptibility, and environmental factors. Based on evidence from three prospective epidemiological studies, the International Agency for Research on Cancer and the… Show more

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“…However, H. pylori cannot survive in the metaplastic mucosa, so, some cases, which show no H. pylori infection but have atrophy and intestinal metaplasia in pathological findings, have a possibility to be the H. pylori false-negative cases [5,28,29]. The degree of atrophy and intestinal metaplasia, regarded as precancerous condition [7], is a reliable parameter of a persistent inflammatory condition induced by H. pylori infection. So, aberrant AID expression in non-neoplastic gastric mucosa may have a genotoxic effect linking a persistent inflammatory condition, as well as in the case of hepatocellular carcinoma, cholangiocarcinoma, and colitisassociated colorectal cancer [18][19][20].…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…However, H. pylori cannot survive in the metaplastic mucosa, so, some cases, which show no H. pylori infection but have atrophy and intestinal metaplasia in pathological findings, have a possibility to be the H. pylori false-negative cases [5,28,29]. The degree of atrophy and intestinal metaplasia, regarded as precancerous condition [7], is a reliable parameter of a persistent inflammatory condition induced by H. pylori infection. So, aberrant AID expression in non-neoplastic gastric mucosa may have a genotoxic effect linking a persistent inflammatory condition, as well as in the case of hepatocellular carcinoma, cholangiocarcinoma, and colitisassociated colorectal cancer [18][19][20].…”
Section: Discussionmentioning
“…Well-differentiated adenocarcinoma, which is associated with Helicobacter pylori infection, was considered to develop through sequential stages-such as chronic gastritis, atrophy, intestinal metaplasia, and dysplasia [3][4][5][6][7]. As for the carcinogenesis of early gastric cancer (GC), p53 mutation has been detected in 25-34% of early GC [6,8], and the occurrence of p53 mutation has been found more in well-differentiated adenocarcinoma [9].…”
Section: Introductionmentioning
“…In späteren Studien konnten die Ergebnisse, allerdings mit einer geringeren Assoziation, bestä-tigt werden [16,17]. Da aber die Prävalenz der Helicobacterinfektion sowohl in den Entwicklungsländern als auch in den Industrienationen sehr hoch ist, ließen sich auch bei einem moderatem Zusammenhang von 2-bis 3-fach etwa 60% der Magenkarzinome durch eine H.-pylori-Infektion erklären.…”
Section: Helicobacter-pylori-infektionunclassified
“…Although it has been reported that simple eradication of H Pylori without reversing the effects H Pylori has caused on gastric mucosa has limited efficacy in preventing gastric cancer, however there is a need for further investigation in this field [65][66][67] .…”
Section: Carcinoembryonic Antigen (Cea)mentioning