Development of FRET Biosensor to Characterize CSK Subcellular Regulation
Mingxing Ouyang,
Yujie Xing,
Shumin Zhang
et al.
Abstract:C-terminal Src kinase (CSK) is the major inhibitory kinase for Src family kinases (SFKs) through the phosphorylation of their C-tail tyrosine sites, and it regulates various types of cellular activity in association with SFK function. As a cytoplasmic protein, CSK needs be recruited to the plasma membrane to regulate SFKs’ activity. The regulatory mechanism behind CSK activity and its subcellular localization remains largely unclear. In this work, we developed a genetically encoded biosensor based on fluoresce… Show more
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