Development of facial palsy following COVID-19 vaccination: A systematic review

Khurshid, Maman; Ansari, Iflah; Ahmad, Hafsa; Ghaffar, Hafsa; Khurshid, Aiman; Shahid, Abia; Essar, Mohammad Yasir; Ullah, Irfan; Cheema, Huzaifa Ahmad

doi:10.1016/j.amsu.2022.104758

Cited by 8 publications

(12 citation statements)

References 52 publications

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“…This could be elucidated by the variation in sample size and baseline characteristics. However, our results are in agreement with Khurshid et al [ 49 ] in the case that the majority of symptoms have appeared following the first dose of the vaccines.…”

Section: Discussionsupporting

confidence: 93%

“…In previous systematic reviews conducted by Shahsavarinia et al [ 10 ] and Khurshid et al [ 49 ], the most notable comorbidities identified among these studies were hypertension followed by diabetes and dyslipidemia, which is consistent with our study. At the same time, in the current study, we conducted the analytical test to determine the discrepancy between the variables and prognosis.…”

Section: Discussionsupporting

confidence: 92%

“…On the other hand, our study represented that (62.8%) of the patients had unilateral-side complaints. As evidenced by Khurshid et al [ 49 ], most of the patients (53.45%) presented with bilateral facial weakness.…”

Section: Discussionmentioning

confidence: 86%

“…Our findings are in the same direction as the former reviews performed by Sriwastava et al [ 50 ] and Shahsavarinia et al [ 10 ] in terms of the association between the type of vaccines and the incidence of facial palsy. Unlikely, Khurshid et al [ 49 ] reported that most of the cases had bell’s palsy after taking the AstraZeneca vaccine. This could be elucidated by the variation in sample size and baseline characteristics.…”

Section: Discussionmentioning

confidence: 99%

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Bell’s Palsy and COVID-19 Vaccines: A Systematic Review and Meta-Analysis

et al. 2023

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Introduction: Once the COVID-19 pandemic was declared, the world was waiting for the clue that would be able to cut down the progression of the disease. Vaccines play a crucial role in reducing the disease and saving many people worldwide. However, there are several side effects of these vaccines, like pain, fatigue, fever, and neurological defects like Bell’s palsy. In this systematic review, we presented evidence about the occurrence of Bell’s palsy followed by COVID-19 vaccination. Methods: We searched PubMed, SCOPUS, EBSCO, and Web of Science (WOS) from inception till October 2022. The quality assessment was conducted using the Joanna Briggs Institute, National Institute of Health, and Newcastle-Ottawa. The analysis was conducted on SPSS. Results: Thirty-five records were involved in our study. The results of our cases revealed that most of the patients (62.8%) experienced unilateral facial paralysis. Also, the majority of the cases were reported after the first dose, and most cases were after Pfizer, AstraZeneca, and Sputnik V vaccines, respectively. The patients who were treated with corticosteroids, IVIG, and anti-viral drugs, showed marked recovery afterward. Conclusion: The rate ratio of Bell’s palsy after COVID-19 vaccination was 25.3 per 1,000,000. The ratio was higher after the first dose compared to the second dose and was higher among those who took Oxford/AstraZeneca vaccine compared to other vaccines. However, this condition was reported in a small number of cases among a large number of vaccinated people worldwide. It is important to note that the benefits of getting vaccinated far outweigh any potential risks.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Bell’s Palsy and COVID-19 Vaccines: A Systematic Review and Meta-Analysis

et al. 2023

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“…We believe that our patient had BPFP as a result of COVID-19, as there was a close relationship between this infection and facial nerve palsy and other secondary causes were excluded. In addition to SARS-CoV-2 infection, paralysis of this nerve is reported to be associated with anti-COVID-19 vaccination, although the pathophysiological mechanism remains unclear [ 15 , 16 ]. We hypothesized that the possible etiopathogenesis of facial paralysis in COVID-19 and post-vaccination patients is similar.…”

Section: Discussionmentioning

confidence: 99%