Development of cortical electrical activity in the rat

Deza, Luis María Ramírez de las Casas; Eidelberg, E.

doi:10.1016/0014-4886(67)90129-x

Cited by 134 publications

(37 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in good agreement with that of Nakayama et al (1978) in the adult rat. (Hyvarinen, 1966;Deza & Eidelberg, 1967;Huttenlocher, 1967;Henderson et al 1971), although the spontaneous firing rates of lateral hypothalamic neurones in 8-21 day old rats have already reached characteristically low adult levels (Almli, McMullen & Golden, 1976). According to Boulant & Bignall (1973) The events which determine the increase in firing rates of preoptic and anterior hypothalamic neurones during the postnatal period are not known.…”

Section: Resultsmentioning

confidence: 99%

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Hori¹,

Shinohara²

1979

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Single unit activities were recorded from the neurones in the preoptic area and anterior hypothalamus of developing new-born rats (aged 1-24 days old) during thermal stimulation of the brain. During the first 2 weeks of life, about 80 % of these neurones had low spontaneous firing rates between 0.1 and 5 impulses/sec at 38 0C hypothalamic temperature (Thyp).2. Out of 640 units studied, 118 units increased the firing rate upon elevation of ThyP (warm-units) and fourteen showed the opposite type of response to temperature changes (cold-units),. Warm-units were founcli the rats of all the age span studied and cold-units were recorded in the rats more than 8 days old.3. Thermal coefficients of warm-units and cold-units varied between +0i11 and +2-47 and between -0.10 and -0*49 impulses/sec. 0C, respectively. Number of warm-units with higher rates of firing and greater thermal coefficients, comparable to those of warm-units in the adult, gradually increased with growth. The thermal responsiveness of warm-units, when expressed by Q10, are already high even in the immediate neonatal period. Their Q10 values were in the range between 2 and 38X5 (mean 6.4).4. Units responding to extrahypothalamic temperatures were only found in the rats more than 14 days old.5. All the six warm-units tested increased the firing rates following subcutaneous injections of capsaicin, while the majority of thermo-unresponsive units were not affected by this drug.6. It is suggested that thermo-responsive neurones in the preoptic area and anterior hypothalamus in the new-born rat have attained some degree of electrophysiological maturity, despite their slowly firing characteristics.

show abstract

Section: Resultsmentioning

confidence: 99%

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Hori¹,

Shinohara²

1979

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…In addition, the LTS rhythm may contribute to the generation of certain kinds of electroencephalographic (EEG) rhythms of the forebrain. Normal rats have slow, irregular EEGs at early ages, and these develop into faster, more complex and regular patterns with maturation (Deza and Eidelberg, 1967;Gramsbergen, 1976;Snead and Stephens, 1983). Furthermore, the absence of interneuronal gap junctions is associated with a decrease in gamma oscillations in the connexin36 knock-out mouse (Buhl et al, 2003).…”

Section: Significance Of the Lts Cell Synchronizing Mechanismmentioning

confidence: 99%

Abrupt Maturation of a Spike-Synchronizing Mechanism in Neocortex

Long¹,

Cruikshank²,

Jutras³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

Synchronous activity is common in the neocortex, although its significance, mechanisms, and development are poorly understood. Previous work showed that networks of electrically coupled inhibitory interneurons called low-threshold spiking (LTS) cells can fire synchronously when stimulated by metabotropic glutamate receptors. Here we found that the coordinated inhibition emerging from an activated LTS network could induce correlated spiking patterns among neighboring excitatory cells. Synchronous activity among LTS cells was absent at postnatal day 12 (P12) but appeared abruptly over the next few days. The rapid development of the LTS-synchronizing system coincided with the maturation of the inhibitory outputs and intrinsic membrane properties of the neurons. In contrast, the incidence and magnitude of electrical synapses remained constant between P8 and P15. The developmental transformation of LTS interneurons into a synchronous, oscillatory network overlaps with the onset of active somatosensory exploration, suggesting a potential role for this synchronizing system in sensory processing.

show abstract

“…The playful activities of the rats are complete by the stage of 35 days, and sexual maturity is attained by 50 to 60 days (Tilney, 1933). The end of the most rapid phase of myelination takes place around P30 (Norton and Poduslo, 1973) and adult spectral com position of electroencephalographic activity is reached by 4 weeks of postnatal life in the rat (Deza and Eidelberg, 1967;Yoshii and Tsukiyama, 1951). This quite active maturation phase translates into an increase in LCBF rates in the brain between P21 and P35.…”

Section: Correlation Between Lcbf and Lcmrgic In The Developing Ratmentioning

confidence: 99%

Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [¹⁴C]Iodoantipyrine Technique in Freely Moving Rats

Nehlig

Vasconcelos

Boyet

1989

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary:The postnatal changes in local cerebral blood flow in freely moving rats were measured by means of the quantitative autoradiographic e 4C]iodoantipyrine method. The animals were studied at 10, 14, 17, 21, and 35 days and at the adult stage. At 10 days after birth, rates of blood flow were very low and quite homogeneous in most cerebral structures except in a few posterior areas. From these relatively uniform levels, values of local ce rebral blood flow rose notably to reach a peak at 17 days in all brain regions studied. Rates of blood flow decreased between 17 and 21 days after birth and then increased from weaning time to reach the known characteristic dis tribution of the adult rat. The postnatal evolution of local cerebral blood flow in the rat is in good agreement with Local cerebral blood flow (LCBF) techniques have been extensively used to map changes in ce rebral metabolic rate in a variety of animal species including rat, cat, piglet, sheep, dog, monkey, and humans (Ca vazutti and Duffy, 1982; Flecknell et aI., 1983; Hascoet et aI. , 1988; Hosokawa et aI. , 1977; Kennedy et aI., 1972;Lassen and Ingvar, 1972; Plotkine et aI., 1986; Raichle et aI. , 1983; Reivich et aI., 1968 Reivich et aI., , 1969 Rosenberg et aI. , 1982; Sakurada et aI. , 1978;Sokoloff, 1961). Indeed, it has been shown in adult animals that in most phys iological or pharmacological states, functional ac tivity in the different structures of the central ner vous system regulates the local rate of energy me tabolism and that LCBF is coupled to local metabolic demand (Des Rosiers et aI., 1974; McCulReceived December 12, 1988; revised March 30, 1989; ac cepted April 7, 1989 579previous studies in other species such as dog and humans that also show higher rates of cerebral blood flow and glucose utilization at immature stages. However, in the rat, local cerebral blood flow and local cerebral glucose utilization are not coupled over the whole postnatal pe riod studied, since blood flow rates reach peak values at 17 days whereas glucose utilization remains still quite low at that stage. The high rate of cerebral blood flow in the 17-day-old rat may reflect the energetic and biosynthetic needs of the actively developing brain that are completed by the summation of glucose and ketone body utilization. Reivich, 1974;Sokoloff, 1961Sokoloff, , 1981. Studies performed in immature dogs (Gre goire et aI. , 1978) and in human infants and children (Chugani and Phelps, 1986; Chugani et aI., 1987;Kennedy and Sokoloff, 1957) were also able to show that, in newborns as in adults, cerebral blood flow and metabolism are tightly coupled.The e4C]iodoantipyrine autoradiographic method of Sakurada et al. (1978) requires catheterization of blood vessels in order to permit administration of the tracer and to facilitate collection of timed arte rial blood samples. For these reasons, this tech nique has been mostly used in animals of a quite large size such as adult rats (Ingvar et aI., 1981; McCulloch et aI. , 1982; Mraovitch et aI. , 1986) or c...

show abstract

Development of cortical electrical activity in the rat

Cited by 134 publications

References 20 publications

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Abrupt Maturation of a Spike-Synchronizing Mechanism in Neocortex

Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [¹⁴C]Iodoantipyrine Technique in Freely Moving Rats

Contact Info

Product

Resources

About

Development of cortical electrical activity in the rat

Cited by 134 publications

References 20 publications

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Hypothalamic thermo‐responsive neurones in the new‐born rat.

Abrupt Maturation of a Spike-Synchronizing Mechanism in Neocortex

Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [14C]Iodoantipyrine Technique in Freely Moving Rats

Contact Info

Product

Resources

About

Postnatal Changes in Local Cerebral Blood Flow Measured by the Quantitative Autoradiographic [¹⁴C]Iodoantipyrine Technique in Freely Moving Rats