Development of Antimicrobial Peptides from Amphibians

Mangoni, Maria Luisa; Casciaro, Bruno

doi:10.3390/antibiotics9110772

Cited by 16 publications

(9 citation statements)

References 24 publications

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“…The skin of amphibians is capable of secreting abundant peptides, in which AMPs have been studied most extensively [27]. Besides antibacterial activity, AMPs have been reported to exert many other pharmacological effects, such as anti-oxidation, anti-tumor, anti-septicemic, and anti-inflammatory activities [28][29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Xiong

Feng

et al. 2021

Viruses

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Several years have passed since the Zika virus (ZIKV) pandemic reoccurred in 2015–2016. However, there is still a lack of proved protective vaccines or effective drugs against ZIKV. The peptide brevinin-2GHk (BR2GK), pertaining to the brevinin-2 family of antimicrobial peptides, has been reported to exhibit only weak antibacterial activity, and its antiviral effects have not been investigated. Thus, we analyzed the effect of BR2GK on ZIKV infection. BR2GK showed significant inhibitory activity in the early and middle stages of ZIKV infection, with negligible cytotoxicity. Furthermore, BR2GK was suggested to bind with ZIKV E protein and disrupt the integrity of the envelope, thus directly inactivating ZIKV. In addition, BR2GK can also penetrate the cell membrane, which may contribute to inhibition of the middle stage of ZIKV infection. BR2GK blocked ZIKV E protein expression with an IC50 of 3.408 ± 0.738 μΜ. In summary, BR2GK was found to be a multi-functional candidate and a potential lead compound for further development of anti-ZIKV drugs.

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Section: Discussionmentioning

confidence: 99%

Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Xiong

Feng

et al. 2021

Viruses

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“…AMPs generated by a variety of vertebrates, invertebrates, and plants are an evolutionarily preserved constituent of the host’s innate immunity [ 56 ]. In addition to their main role of protection from harmful microorganisms invading the host, they also have roles involved in host immune modulation, such as endotoxin neutralization, chemotaxis, and healing injuries [ 57 ].…”

Section: Skin Immunologymentioning

confidence: 99%

“…Having this activity must be vital for metamorphs because metamorphosis-related corticosteroids repress the innate immune system through a transitional stage in which they have to adapt to both water and land [ 59 ]. All of these findings lead to common ground about AMPs, which is that they are vital for protection against pathogens with additional roles such as healing skin injuries, endotoxin neutralization, and chemotaxis [ 57 ].…”

Section: Skin Immunologymentioning

confidence: 99%

The Complex Bridge between Aquatic and Terrestrial Life: Skin Changes during Development of Amphibians

Çömden

Yenmiş

Çakır

2023

JDB

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Amphibian skin is a particularly complex organ that is primarily responsible for respiration, osmoregulation, thermoregulation, defense, water absorption, and communication. The skin, as well as many other organs in the amphibian body, has undergone the most extensive rearrangement in the adaptation from water to land. Structural and physiological features of skin in amphibians are presented within this review. We aim to procure extensive and updated information on the evolutionary history of amphibians and their transition from water to land—that is, the changes seen in their skin from the larval stages to adulthood from the points of morphology, physiology, and immunology.

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“…In addition to AMPs, other peptides isolated from urodeles can also have diverse pharmacological properties, such as antioxidant, and immunomodulatory activities (Coorens et al, 2017;Holthausen et al, 2017;Lee et al, 2019;Woodhams et al, 2020). Some examples of the last one is the neutralization of endotoxins, chemotaxis, and wound healing activities (Mangoni and Casciaro, 2020).…”

Section: Peptidesmentioning

confidence: 99%

The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians

et al. 2022

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Urodele amphibians (∼768 spp.), salamanders and newts, are a rich source of molecules with bioactive properties, especially those isolated from their skin secretions. These include pharmacological attributes, such as antimicrobial, antioxidant, vasoactive, immune system modulation, and dermal wound healing activities. Considering the high demand for new compounds to guide the discovery of new drugs to treat conventional and novel diseases, this review summarizes the characteristics of molecules identified in the skin of urodele amphibians. We describe urodele-derived peptides and alkaloids, with emphasis on their biological activities, which can be considered new scaffolds for the pharmaceutical industry. Although much more attention has been given to anurans, bioactive molecules produced by urodeles have the potential to be used for biotechnological purposes and stand as viable alternatives for the development of therapeutic agents.

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Development of Antimicrobial Peptides from Amphibians

Abstract: Since the discovery of magainins from the skin secretions of the African toad Xenopus laevis by Michael Zasloff in 1987, an increasing number of antimicrobial peptides (AMPs) has been identified in different anuran species and studied in detail [...]

Cited by 16 publications

References 24 publications

Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity

Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity

The Complex Bridge between Aquatic and Terrestrial Life: Skin Changes during Development of Amphibians

The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians

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