Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging

Kanazaki, Kengo; Sano, Kohei; Makino, Akihiro; Shimizu, Yoichi; Yamauchi, Fumio; Ogawa, Satoshi; Ding, Ning; Yano, Tetsuya; Temma, Takashi; Ono, Masahiro; Saji, Hideo

doi:10.1016/j.nano.2015.07.007

Cited by 37 publications

(24 citation statements)

References 35 publications

(43 reference statements)

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“…Furthermore, 20-nm IONPs alone (without scFv) increased photoacoustic signal in neither N87 nor SUIT2 tumors. Berlin Blue staining of N87 and SUIT2 tumors treated with SNP20 has revealed that N87 tumors uptake relatively greater amounts of IONPs (62). These results all indicate that scFv offers a high degree of specificity toward HER2-expressing cells/ tumors and can serve as an efficient carrier of IONPs for imaging purposes.…”

Section: Use Of Scfv For Delivery Of Iron Oxide Nanoparticles For Tummentioning

confidence: 79%

“…Kanazaki and colleagues produced a trastuzumab-based scFv and used it to selectively deliver iron oxide nanoparticles (IONPs) of different sizes (20,50 and 100 nm) to HER2-expressing cells and tumor xenografts (62). IONPs have a biodegradable nature and represent low cytotoxicity, making them a favorable probe for photoacoustic cancer imaging.…”

Section: Use Of Scfv For Delivery Of Iron Oxide Nanoparticles For Tummentioning

confidence: 99%

See 1 more Smart Citation

Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery

Safdari

Ahmadzadeh

Khalili

et al. 2016

Mol Med

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Section: Use Of Scfv For Delivery Of Iron Oxide Nanoparticles For Tummentioning

confidence: 79%

Section: Use Of Scfv For Delivery Of Iron Oxide Nanoparticles For Tummentioning

confidence: 99%

Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery

Safdari

Ahmadzadeh

Khalili

et al. 2016

Mol Med

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“…Other than MRI signal, IONP have been recognized as a PA contrast agent. Kanazaki et al conjugated the HER2 antibody on IONP, enabling NP to bind specifically on cells with HER2 expression on the cell surface then HER2‐positive tumors were observed under PA imaging . Therefore, the imaging methods of IONP are very different from QD and AuNP due to their unique magnetic properties.…”

Section: Intracellular Imaging Methods Of Metallic Npmentioning

confidence: 99%

Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways

Chen

Monteiro‐Riviere

Zhang

2016

WIREs Nanomed Nanobiotechnol

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Metallic nanoparticles (NP) have been used for biomedical applications especially for imaging. Compared to nonmetallic NP, metallic NP provide high contrast images because of their optical light scattering, magnetic resonance, X-ray absorption, or other physicochemical properties. In this review, a series of in vitro imaging techniques for metallic NP will be introduced, meanwhile their strengths and weaknesses will be discussed. By utilizing these imaging methods, the cellular uptake of metallic NP can be easily visualized to better understand the endocytic mechanisms of NP intracellular delivery. Several types of metallic NP that are used for imaging or as contrast agents such as quantum dots, gold, iron oxide, and other metallic NP will be presented. Cellular uptake of metallic NP and associated endocytic mechanisms highly depends upon the NP size, charge, surface coating, shape, or other factors such as cell type, cell differentiation status, cell surface status, external forces, protein binding, temperature, and the biological milieu. Classical endocytic routes such as lipid raft-mediated pathways, clathrin or caveolae-mediated pathways, macropinocytosis, and phagocytosis have been investigated, yet there is still a demand to determine other endocytic pathways. Knowing the different methodologies used to determine the endocytic pathways will increase the understanding of NP toxicity, cancer cell targeting, and imaging, so that surface coatings can be created for efficient cell uptake of metallic NP with minimal cytotoxicity WIREs Nanomed Nanobiotechnol 2017, 9:e1419. doi: 10.1002/wnan.1419 For further resources related to this article, please visit the WIREs website.

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“…To date, affinity ligands have been used to deliver SPIONs to a range of different targets, including tumor cells, tumor vasculature, and atherosclerotic plaques [11,48]. In addition to ligands that have been successfully used for these purposes [49,50], antibodies [51][52][53] and aptamers [54,55] are also routinely and successfully used.…”

Section: Functional Targetingmentioning

confidence: 99%

Physicochemical Properties of Magnetic Nanoparticles: Implications for Biomedical Applications In Vitro and In Vivo

Belanova¹,

Gavalas

Makarenko

et al. 2018

Oncol Res Treat

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Magnetic and superparamagnetic iron oxide nanoparticles are emerging as promising candidates for various applications in biology and medicine, and especially in oncology. These applications, however, require that a specific set of physical, chemical, and biological properties be combined in a given sample of nanoparticles for them to act as intended. Some of these properties are fundamental: They strictly determine the nanoparticles' behavior both in vitro and in vivo. These properties are the charge, the solution stability and zeta potential, and the coating of the nanoparticles. A certain combination of these properties may satisfy a researcher in an in vitro study, but other properties should also be considered when in vivo applications are planned. For in vivo experiments, additional determinants of the quality of nanoparticles are their size, shape, modifications with targeting moieties, and degradation/excretion pathways. All these properties are in the focus of the present review.

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Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging

Cited by 37 publications

References 35 publications

Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery

Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery

Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways

Physicochemical Properties of Magnetic Nanoparticles: Implications for Biomedical Applications In Vitro and In Vivo

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