Development of a validated spectrofluorimetric method for assay of sotalol hydrochloride in tablets and human plasma: application for stability-indicating studies

Ibrahim, F.; El-Brashy, A.; El-Awady, Mohamed I.; Abdallah, Nora A.

doi:10.1515/chem-2019-0008

Cited by 9 publications

(3 citation statements)

References 22 publications

(25 reference statements)

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“…Therefore, several spectrofluorimetric methods were reported for the deter-mination of β-blockers in pharmaceutical formulations, biological samples, and the environment. [37][38][39][40] For example, Bakir et al in 2018 38 determined atenolol in a pharmaceutical formulation by a fluorimetric method based on the atenolol quenching effect on the photoluminescence of gold nanoparticles (AuNPs). Also, Abdewelwahab et al 37 studied the native fluorescence of bisoprolol and rosuvastatin in human plasma by spectrofluorimetry.…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of beta-blockers atenolol and bisoprolol fumarate residues in Senegal natural waters

Gueye

Diaw

Mbaye

et al. 2023

Maced. J. Chem. Chem. Eng.

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A spectrofluorimetric method was developed to determine residues of two β-blockers, atenolol (AT) and bisoprolol fumarate (BF), in Senegal's natural waters. The electronic absorption and fluorescence spectral properties of both β-blockers were investigated in several organic solvent mixtures [e.g., MeOH/H2O (60/40 v/v), cyclodextrins (β-cyclodextrin, HP-β-CD], and in the presence of surfactants (SDS, Triton X, Tween 80). After optimization, satisfactory analytical figures of merit were obtained for the determination of both β-blockers: concentration linear dynamic range of over one to two orders of magnitude, limits of detection (LODs) from 1.3 to 5.4 ng/ml for BF and from 1.2 to 3.7 ng/ml for AT, limits of quantification (LOQs) from 4.5 to 18.1 ng/ml for BF and from 4.0 to 12.5 ng/ml for AT. Relative standard deviations (RSDs) were between 2.1 and 5.3 %, according to the β-blockers. The spectrofluorimetric method was applied to the analysis of fortified river water and wastewater (effluent) collected in Senegal and France and spiked with both β-blockers. It yielded good recovery values, from 93.3 to 107.8 % for AT and from 97.4 to 108.9 % for BF. Our results demonstrated the simplicity, rapidity, and sensitivity of the spectrofluorimetric method to quantify residues of β-blockers in environmental waters.

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Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of beta-blockers atenolol and bisoprolol fumarate residues in Senegal natural waters

Gueye

Diaw

Mbaye

et al. 2023

Maced. J. Chem. Chem. Eng.

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“…Conductometric titration with a solution of argentum nitrate sotalol hydrochloride in the substance and drugs is described [12]. Fawzia A. Ibrahim and co-authors proposed a sensitive method of spectrofluorimetric determination of sotalol in dosage forms and plasma by its own fluorescence [13]. Another spectrofluorimetric technique is based on quenching the fluorescence intensity of the palmate complex with cucurbituril with sotalol [14].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric methods for quantitative determination of sotalol in tablets

Maletska

Vasyuk

2022

SR: PS

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The aim of the work. To develop a method for spectrophotometric determination of sotalol with diazonium salts. Establish optimal conditions for the quantitative determination of sotalol in drugs. Validate the developed methodology. Materials and methods. Reagents and solvents used in the study were: diazole red 2J (obtained from NVF “Sinbias”), tablets “Sotalol Sandoz” 40 mg (Salyutas Pharma GmbH, series JZ1188), “Sotalol Sandoz” 80 mg (Salyutas Pharma GmbH, series KA0464) and “Sotalol Sandoz” 160 mg (Salyutas Pharma GmbH, series JY3504), methanol (LAB-SCAN, Ireland, batch № 5120/13), sodium carbonate (Sinbias) and purified water were also used. Analytical equipment: spectrophotometer “SPECORD-200” (Analytic Jena AG, Germany), scales laboratory electronic RADWAG XA 210.4Y, bath ultrasonic Sonorex Digitec DT100H, laboratory glassware of class A. All studies were conducted in the experimental pharmaceutical research department of the scientific medical laboratory center (SMLC) of the Zaporizhzhia State Medical University. Results and discussion. The technique of spectrophotometric determination of the quantitative content of sotalol based on its reaction with red diazole in water-methanol medium has been developed. The stoichiometric ratios of the reactive components as 1:1 were obtained by the methods of continuous changes and the saturation method. Validation of the developed on such indicators as linearity, precision, correctness and robustness is carried out. Based on these data, the developed method is correct and could be used in the quality control departments of chemical and pharmaceutical companies. Conclusions. A method of quantitative spectrophotometric determination of sotalol in the tablet dosage form “Sotalol Sandoz” 40 mg, “Sotalol Sandoz” 80 mg and “Sotalol Sandoz” 160 mg of industrial production was developed, validation characteristics were investigated: linearity, precision, correctness, range of application and robustness

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“… 22 Furthermore, indicators of the PR interval and QRS duration of the ECG were also used to evaluate atrioventricular and intraventricular conductivities. In order to validate and define the sensitivity of the experimental system, sotalol hydrochloride (Sol), an antiarrhythmic agent, which is known to prolong the PR interval and QT interval and widen the QRS duration, 23 was used as the positive control drug. In addition, an implantable telemetry system strongly recommended by ICH and CFDA in safety pharmacology studies and has been used in the pharmaceutical industry for safety evaluation, 24 was applied in the present study.…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

Liu

Wang

Wan

et al. 2020

DDDT

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Purpose: Anisodine hydrobromide (Ani) is isolated from the medicinal plant Anisodus tanguticus (Maxim.) Pascher for clinical use. Although considerable research regarding Ani has been reported, the safety profiles of Ani are currently unknown. This study investigated the cardiorespiratory effects of Ani in conscious dogs to provide clinicians a detailed safety profile of Ani on the cardiorespiratory system. Materials and Methods: Using the Latin square design, the study was divided into six phases, where in each phase, six telemetered beagle dogs received one dose of normal saline or sotalol hydrochloride or Ani (0.1, 0.4, 1.6, or 6.4 mg/kg). Electrocardiogram, blood pressure (BP) and respiratory parameters were collected before and after administration for 24 hours. Statistical comparisons were performed at scheduled time-points. Results: The heart rate was significantly increased, PR and QT C V intervals were significantly shortened in Ani 0.4, 1.6, 6.4 mg/kg treatment group after drug administration. Compared with the saline group, a significant increase in heart rate and shortening of PR, QT C V intervals were observed in the Ani 1.6, 6.4 mg/kg treatment groups from 5 min to 4 h time-points. Diastolic and mean BP were significantly increased in Ani 1.6, 6.4 mg/kg from 1 h to 2 h time-points compared to those of the saline control. Accelerated breathing was observed in the first 20 min after Ani 0.4, 1.6, and 6.4 mg/kg treatment, although not statistically significant. Furthermore, no significant differences were observed in any of the corresponding indexes of Ani 0.1 mg/kg treatment group at different time-points compared to those of the saline group. Conclusion: Ani may have adverse effects on the cardio-respiratory systems of dogs at doses above 0.4 mg/kg, whereas Ani 0.1 mg/kg was devoid of potentially deleterious effects on cardiorespiratory function.

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Development of a validated spectrofluorimetric method for assay of sotalol hydrochloride in tablets and human plasma: application for stability-indicating studies

Cited by 9 publications

References 22 publications

Spectrofluorimetric determination of beta-blockers atenolol and bisoprolol fumarate residues in Senegal natural waters

Spectrofluorimetric determination of beta-blockers atenolol and bisoprolol fumarate residues in Senegal natural waters

Spectrophotometric methods for quantitative determination of sotalol in tablets

<p>Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs</p>

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