2015
DOI: 10.1590/s0102-86502015001000002
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Abstract: PURPOSE:To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs. METHODS:Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg per os). The animals were autoimplanted subcutaneously with 4x4-mm uterine fragments to induce endometr… Show more

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Cited by 8 publications
(6 citation statements)
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“…It can be seen that the interaction between glandular epithelial cells and stromal cells is essential in the formation of endometriosis lesions (39). Our results showed a 100% success rate in inducing endometriosis using mixed human immortalized endometriosis cells, which is better than other induced endometriosis models (40)(41)(42). These lesions are characterized by the presence of endometriosis glands lined with cylindrical and flattened epithelial cells and surrounded by dense stromal cells in the subcutaneous adipose tissue.…”
Section: Discussionmentioning
confidence: 59%
“…It can be seen that the interaction between glandular epithelial cells and stromal cells is essential in the formation of endometriosis lesions (39). Our results showed a 100% success rate in inducing endometriosis using mixed human immortalized endometriosis cells, which is better than other induced endometriosis models (40)(41)(42). These lesions are characterized by the presence of endometriosis glands lined with cylindrical and flattened epithelial cells and surrounded by dense stromal cells in the subcutaneous adipose tissue.…”
Section: Discussionmentioning
confidence: 59%
“…In January 2015, Edson Ximenes Gomes Pereira et al published a similar study about an animal model that could be used to understand the pathophysiology of endometriosis and the effects of certain pharmacological agents on endometriotic animals [ 31 ]. The study used 53-month-old rats that were divided into four groups according to the pharmacological agent with which each was treated: (1) the estradiol group, (2) the medroxyprogesterone acetate group, (3) the triptorelin pamoate group, and (4) the acetylsalicylic acid [ 17 ].…”
Section: Resultsmentioning
confidence: 99%
“…The results showed that the weight of the endometrioma and hemiuterus was linked to the pharmacological agents provided to the animals. Moreover, the experimental model of subcutaneous endometriosis is a good option for researchers due to its reproducibility, cost-effectiveness, and facile implementation [ 31 ].…”
Section: Resultsmentioning
confidence: 99%
“…The method described by Pereira et al [ 25 ] was used to induce endometriosis. Briefly, thirty adult female Wistar rats were anesthetized with Diazepam (10 mg/kg: i.p.)…”
Section: Methodsmentioning
confidence: 99%
“…At these doses, the ethanol extract of P. americana seeds was found to prevent tamoxifen-induced endometrial hyperplasia in rats [20]. e method described by Pereira et al [25] was used to induce endometriosis. Briefly, thirty adult female Wistar rats were anesthetized with 2…”
Section: Justification Of the Doses Usedmentioning
confidence: 99%