Abstract:SUMMARY.A specific polarisation fluoroimmunoassay for the measurement of paracetamollevels in serum has been developed for use in emergency toxicological screening. It is based on the use of a fluorescein-labelled analogue and a sheep antiserum and exploits the rapid dissociation kinetics of the hapten-antibody complex to enable the label and antiserum to be combined as a single reagent. Paracetamollevels are determined by adding 5 I1L of serum to 1·5 mL of the single reagent, incubation at ambient temperature… Show more
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