Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers

Pai, Jing-Hong; Yang, Chih‐Tsung; Hsu, Hung-Yao; Wedding, A. B.; Thierry, Benjamin

doi:10.1016/j.aca.2017.04.015

Cited by 26 publications

(10 citation statements)

References 29 publications

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“…Figure 19 depicts the structure of compounds used to introduce carboxyl groups on AuNR. A characteristic that have in common is to include a terminal thiol function to create strong Au-S bonds and a carboxylic acid function at the other end, typically MUA [ 20 , 156 , 157 , 158 , 159 ], MHDA [ 160 , 161 ], or mercaptoPEG acid derivatives [ 162 , 163 , 164 , 165 , 166 , 167 ]. This general strategy has been applied to decorate AuNR with bioreceptors both in solution or once deposited on solid substrates (essentially glass slides) using the mercaptocarboxylic acids alone or in mixture with other thiols like mPEG-SH or 11-mercaptoundecanol in various proportions.…”

Section: Functionalization Methods Of Gold Nanorodsmentioning

confidence: 99%

“…Grafting of the antibody to the AuNR is then performed by one of the methods described in part 4. Occasionally, the reverse process by which the antibody is first grafted onto the AuNR in solution then the conjugate is immobilized onto glass slides treated with APTES and glutaraldehyde was also performed [ 164 ].…”

Section: Applications Of Aunrs In Lspr Biosensingmentioning

confidence: 99%

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Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Pellas

Mazouzi

et al. 2020

Biosensors

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Nanoparticles made of coinage metals are well known to display unique optical properties stemming from the localized surface plasmon resonance (LSPR) phenomenon, allowing their use as transducers in various biosensing configurations. While most of the reports initially dealt with spherical gold nanoparticles owing to their ease of synthesis, the interest in gold nanorods (AuNR) as plasmonic biosensors is rising steadily. These anisotropic nanoparticles exhibit, on top of the LSPR band in the blue range common with spherical nanoparticles, a longitudinal LSPR band, in all respects superior, and in particular in terms of sensitivity to the surrounding media and LSPR-biosensing. However, AuNRs synthesis and their further functionalization are less straightforward and require thorough processing. In this paper, we intend to give an up-to-date overview of gold nanorods in LSPR biosensing, starting from a critical review of the recent findings on AuNR synthesis and the main challenges related to it. We further highlight the various strategies set up to coat AuNR with a silica shell of controlled thickness and porosity compatible with LSPR-biosensing. Then, we provide a survey of the methods employed to attach various bioreceptors to AuNR. Finally, the most representative examples of AuNR-based LSPR biosensors are reviewed with a focus put on their analytical performances.

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Section: Functionalization Methods Of Gold Nanorodsmentioning

confidence: 99%

Section: Applications Of Aunrs In Lspr Biosensingmentioning

confidence: 99%

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Pellas

Mazouzi

et al. 2020

Biosensors

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“…Another group also reported a similar technique for the ultrasensitive detection of inorganic pyrophosphatase activity [98]. AuNR functionalisation with nucleic acids [99,100] as well as antibodies [93,101,102] has been widely reported. Kong's group developed a neoteric and cost-efficient sensor for the detection of bleomycin, a drug commonly administered in the treatment of lymphoma, ovarian as well as testicular cancer [103].…”

Section: Localised Surface Plasmon Resonance Sensors For Biomedical Dmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…One is to elongate the nanoparticle and sharpen its apexes. [13][14][15][16] The other way is to change the constituent materials of the nanoparticles, which also plays an important role in the sensor's RI sensitivity. 17,18 Although the RI sensitivity can be greatly improved to 665 nm/RIU through the two methods mentioned above, the sensors cannot work in a broader band because the absorption peaks of metal nanoparticles shi in the visible range.…”

Section: Introductionmentioning

confidence: 99%

Double-exponential refractive index sensitivity of metal–semiconductor core–shell nanoparticles: the effects of dual-plasmon resonances and red-shift

et al. 2018

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Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers

Cited by 26 publications

References 29 publications

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Recent Progress in Optical Sensors for Biomedical Diagnostics

Double-exponential refractive index sensitivity of metal–semiconductor core–shell nanoparticles: the effects of dual-plasmon resonances and red-shift

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