volume 93, issue 0, P3-O-114 2020
DOI: 10.1254/jpssuppl.93.0_3-o-114
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Abstract: 【Background and Objective】 Since mammalian cardiomyocytes exit from cell cycle immediately after birth, the regenerative activity is limited in adult mammalian hearts. The aim of this study is to construct a screening system of the compounds that induce the cell cycle activity in mammalian cardiomyocytes, using Geminin-mAG1, a Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) that is stabilized in S/G2/M phases. 【Methods and Results】 We generated adenovirus vector expressing the FUCCI and infected …

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