Development of a scalable procedure for fine calcium alginate particle preparation

Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

“…Regarding the particles morphology, faster solvent evaporation rate (lower point boiling) usually leads to particles that are more porous due to shorter time for the droplets shrinkage [21,[27][28][29]. Finally, the air outlet temperature is dependent on other process variables [9,24]. Nandiyanto and Okuyama reviewed in detail the particle design (i.e.…”

“…The variables that affect the characteristics of the product and that can be tuned are (i) process parameters, (ii) properties of the liquid feed and (iii) equipment design (Table 1) [6,9,[22][23][24][25][26]. For example, high flow rate of the liquid feed, large nozzle diameter and high formulation concentration favor the formation of larger particles.…”

Hypoxia-mimicking bioactive glass/collagen glycosaminoglycan composite scaffolds to enhance angiogenesis and bone repair

“…An alternative strategy is to target the cellular Hypoxia Inducible Factor (HIF-1α) pathway, which responds to low oxygen concentration (hypoxia) and results in the activation of a cascade of pro-vasculogenic genes critical for angiogenesis, including VEGF mimicking the normal regenerative response [20]. Cobalt ions (Co 2+ ) have the potential to mimic hypoxia, they artificially stabilise the transcription factor HIF-1α [20,21], which then translocates into the nucleus to stimulate the upregulation of pro-vasculogenic genes such as VEGF [22]; this approach has been adopted as a potential neovascularisation strategy in a number of studies [23,24]. Recently, cobalt-releasing bioactive glasses have been developed [25], and their ability to activate the HIF pathway under normoxic conditions was demonstrated [26].…”

Production and characterization of alginate-starch-chitosan microparticles containing stigmasterol through the external ionic gelation technique

“…Biocompatible and biodegradable materials are preferable for use in microparticle production for medicines, food and pesticides products (Chan, 2011) Some encapsulation methods involve organic solvents or other reagents that are incompatible with many biological encapsulants. Solvents are toxic thereby limiting widespread applicability, whereas vitamins, hormones and unsaturated aliphatic compounds are important examples of heat or oxygen labile products (Ribeiro et al, 1999;Schoubben et al, 2010).…”