Development of a primary culture system of rat kidney cortical cells to evaluate the nephrotoxicity of xenobiotics

In Vitro Models for Nephrotoxiciry Screening and Risk Assessment

“…16 '17 They offer systems in which the direct effects of chemicals can be evaluated and manipulated under precisely controlled conditions, in order to distinguish direct and indirect effects at a cellular and subcellular level. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation.…”

In Vitro Models for Nephrotoxiciry Screening and Risk Assessment

“…16 '17 They offer systems in which the direct effects of chemicals can be evaluated and manipulated under precisely controlled conditions, in order to distinguish direct and indirect effects at a cellular and subcellular level. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation.…”

In Vitro Models for Nephrotoxiciry Screening and Risk Assessment

“…16 '17 They offer systems in which the direct effects of chemicals can be evaluated and manipulated under precisely controlled conditions, in order to distinguish direct and indirect effects at a cellular and subcellular level. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation.…”

In Vitro Models for Nephrotoxiciry Screening and Risk Assessment

“…16 '17 They offer systems in which the direct effects of chemicals can be evaluated and manipulated under precisely controlled conditions, in order to distinguish direct and indirect effects at a cellular and subcellular level. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation. This insight has also been used to help screen new chemicals for their potential nephrotoxicity.S, [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The complexity of the kidney does, however, demand a careful match between the in vitro system and the in vivo situation.…”