Development of a novel tissue-engineered nitinol frame artificial trachea with native-like physical characteristics

Sakaguchi, Yasuyoshi; Satô, Toshihiko; Muranishi, Yusuke; Yutaka, Yojiro; Komatsu, Teruya; Omori, Koichi; Nakamura, Tatsuo; Date, Hiroshi

doi:10.1016/j.jtcvs.2018.04.073

Cited by 17 publications

(28 citation statements)

References 24 publications

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“…Nickel‐titanium (NiTi) metal alloys are a well‐established material system that can be initially formed into wires, springs, strips or plates, programmed to adopt a defined shape, and thermally actuated to return to that programmed shape on demand. NiTi alloys have previously been demonstrated to be compatible with a wide range of biomedical and implantable applications, and can be actuated as needed via electrical resistance heating. They are also readily available with defined operating behaviors from several commercial sources.…”

Section: Resultsmentioning

confidence: 99%

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

Kalashnikov

Moraes

2019

Adv Funct Materials

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Manipulating the shape of preformed living tissues can present a novel fabrication route toward complex biological architectures. However, external manipulation of tissues can be challenging to implement robustly at multiple length scales and with high degrees of freedom, particularly in soft fibrous tissue constructs. Here, a versatile platform is developed to drive soft tissue morphodynamics using embeddable shape memory actuators that generate multiscale, repetitive, and highly customized tissue deformation on demand. To achieve this, a thermally isolating coating technique is designed and developed for programmable shape memory wires, which protects surrounding biological materials from cytotoxic heating effects during wire actuation. The coated tissue actuators (CTAs) can then be embedded in engineered tissues and activated to produce both large-and small-scale tissue deformations in a highly customized and reproducible manner. Using this strategy, tissues can be forced to adopt specified shapes, with precise control over cell elongation and orientation within an encapsulating matrix. Furthermore, the system can produce predictable, highly localized, and customizable strains within fibrous matrices, capable of elongating cells and biasing their orientation within degrees of a desired direction. This strategy may hence have broad applicability in both applied tissue biofabrication and for fundamental studies of cell-matrix interactions.

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Section: Resultsmentioning

confidence: 99%

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

Kalashnikov

Moraes

2019

Adv Funct Materials

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“…A number of groups are addressing challenges seen in the clinic through focused and well-controlled preclinical work. Recent advancements in tracheal grafts are broadly focused on preventing adverse host response, [73][74][75] capturing complex native mechanical behavior, [76][77][78][79][80][81] and improving functional integration upon implantation. 76,[82][83][84][85] The Cho group of South Korea has developed a polymeric tracheal replacement graft designed with a ''bellows'' configuration, comprising polycaprolactone, to attempt to capture native-like structure and mechanical behavior.…”

Section: Preclinical Promisementioning

confidence: 99%

The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future

Greaney

Niklason

2021

Tissue Engineering Part B: Reviews

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The development of a tracheal graft to replace long-segment defects has thwarted clinicians and engineers alike for over 100 years. To better understand the challenges facing this field today, we have consolidated all published reports of engineered tracheal grafts used to repair long-segment circumferential defects in humans, from the first in 1898 to the most recent in 2018, totaling 290 clinical cases. Distinct trends emerge in the types of grafts used over time, including repair using autologous fascia, rigid tubes of various inert materials, and pretreated cadaveric allografts. Our analysis of maximum clinical follow-up, as a proxy for graft performance, revealed that the Leuven protocol has a significantly longer clinical follow-up time than all other methods of airway reconstruction. This method involves transplanting a cadaveric tracheal allograft that is first prevascularized heterotopically in the recipient. We further quantified graft-related causes of mortality, revealing failure modes that have been resolved, and those that remain a hurdle, such as graft mechanics. Finally, we briefly summarize recent preclinical work in tracheal graft development. In conclusion, we synthesized top clinical care priorities and design criteria to inform and inspire collaboration between engineers and clinicians toward the development of a functional tracheal replacement graft.

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“…Sakaguchi and colleagues 1 describe an artificial nitinol-frame trachea and believe that this novel construct shares physical characteristics with the native trachea. However, it is unclear if the force measurements of the symmetric tubular nitinol construct-with equal forces in all directions-are comparable to asymmetric native trachea because the measurements were only taken in 1 dimension (ie, anterior cartilaginous to posterior membranous airway) and how that compares with forces in the other dimension (ie, cartilaginous to cartilaginous airway).…”

Section: Jules Lin MDmentioning

confidence: 99%

Nitinol-frame artificial trachea: Knight in shining armor or wolf in sheep's clothing

Lin

2018

The Journal of Thoracic and Cardiovascular Surgery

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Development of a novel tissue-engineered nitinol frame artificial trachea with native-like physical characteristics

Abstract: The novel nitinol artificial trachea reproduced the physical characteristics of the native trachea. We have confirmed cell engraftment, good biocompatibility, and survival of 18 months or longer for this artificial trachea in canine models.

Cited by 17 publications

References 24 publications

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future

Nitinol-frame artificial trachea: Knight in shining armor or wolf in sheep's clothing

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