Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs

Sifi, Amina; Adi-Bessalem, Sonia; Laraba-Djebari, Fatima

doi:10.1016/j.intimp.2018.06.013

Cited by 17 publications

(11 citation statements)

References 66 publications

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“…This economic benefit is reinforced by: (i) the lower cost of feeding and housing chickens, compared to other animals such as horses or sheep, and (ii) the ethical production of IgY from the egg yolk [129,131]. Recently, it has been reported that IgY antibodies effectively neutralize the Aah venom lethality, and could prevent its pathological effects [132].…”

Section: Advanced Scorpion Envenomation Therapiesmentioning

confidence: 99%

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Martin‐Eauclaire

Adi-Bessalem

Hammoudi-Triki

et al. 2019

Toxins

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Because of their venom lethality towards mammals, scorpions of the Androctonus genus are considered a critical threat to human health in North Africa. Several decades of exploration have led to a comprehensive inventory of their venom components at chemical, pharmacological, and immunological levels. Typically, these venoms contain selective and high affinity ligands for the voltage-gated sodium (Nav) and potassium (Kv) channels that dictate cellular excitability. In the well-studied Androctonus australis and Androctonus mauretanicus venoms, almost all the lethality in mammals is due to the so-called α-toxins. These peptides commonly delay the fast inactivation process of Nav channels, which leads to increased sodium entry and a subsequent cell membrane depolarization. Markedly, their neutralization by specific antisera has been shown to completely inhibit the venom’s lethal activity, because they are not only the most abundant venom peptide but also the most fatal. However, the structural and antigenic polymorphisms in the α-toxin family pose challenges to the design of efficient serotherapies. In this review, we discuss past and present accomplishments to improve serotherapy against Androctonus scorpion stings.

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Section: Advanced Scorpion Envenomation Therapiesmentioning

confidence: 99%

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Martin‐Eauclaire

Adi-Bessalem

Hammoudi-Triki

et al. 2019

Toxins

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“…In this study, the kinetic parameters of hFcγRn to quail IgY were also determined. Numerous studies addressed IgY [ 37 , 38 , 39 , 40 ], because IgY is closer to the functional characteristics of IgG [ 37 ], and the research cost of IgY antibody is low, while the damage to animals is small [ 38 , 39 ]. However, there are few studies on the transfer of IgY through hFcγRn to the body and its immunoprotection.…”

Section: Discussionmentioning

confidence: 99%

Study on FcγRn Electrochemical Receptor Sensor and Its Kinetics

Peng

Pang

2020

Molecules

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Neonatal γ-immunoglobulin (IgG) Fc receptor (FcγRn) is a receptor that transports IgG across the intestinal mucosa, placenta, and mammary gland, ensuring the balance of IgG and albumin in the body. These functions of FcγRn depend on the intracellular signal transduction and activation caused by the combination of its extracellular domain and IgG Fc domain. Nevertheless, there are still no kinetic studies on this interaction. Consequently, in the present study, we successfully constructed the human FcγRn (hFcγRn) electrochemical receptor sensor. The signal amplification system formed by chitosan nanogold-hFcγRn protein and horseradish peroxidase was used to simulate the cell signal amplification system in vivo, and the kinetic effects between seven IgG and hFcγRn receptors from different species were quantitatively measured. The results showed that the interaction of these seven IgGs with hFcγRn was similar to the catalytic kinetics of enzyme and substrate, and there was a ligand-receptor saturation effect. The order of the interconnect allosteric constants (Ka), which is similar to the Michaelis constant (Km), was human IgG < bovine IgG < horse IgG < rabbit IgG < sheep IgG < donkey IgG < quail IgY. The results showed that hFcγRn had the strongest ability to transport human IgG, which was consistent with the evolution of the system. Therefore, our hFcγRn electrochemical receptor sensor can be used to measure and evaluate the interconnected allosteric network. It is also an essential parameter of the interaction between hFcγRn and different IgGs and, thus, provides a new detection and evaluation method for immunoemulsion, therapeutic monoclonal antibody therapy, heteroantibody treatment, and half-life research.

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“…Parenteral administration of IgY has not been evaluated but may be of value as a single injection in situations such as the need for antivenom treatment. IgY-based antivenom given parenterally resulted in complete protection in animal models of lethal venomous bites and stings (318)(319)(320)(321).…”

Section: Principles Regarding the Clinical Use Of Igy Physicochemical Properties Of Chicken Igy Contribute To Safetymentioning

confidence: 99%

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

et al. 2021

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Antiviral, antibacterial, and antiparasitic drugs and vaccines are essential to maintaining the health of humans and animals. Yet, their production can be slow and expensive, and efficacy lost once pathogens mount resistance. Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile, primarily in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost. IgY antibodies can readily be generated in large quantities with minimal environmental harm or infrastructure investment by using egg-laying hens. We summarize a variety of IgY uses, focusing on their potential for the detection, prevention, and treatment of human and animal infections.

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Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs

Cited by 17 publications

References 66 publications

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Serotherapy against Voltage-Gated Sodium Channel-Targeting α-Toxins from Androctonus Scorpion Venom

Study on FcγRn Electrochemical Receptor Sensor and Its Kinetics

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

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