Abstract:Fanconi anemia (FA) patients frequently develop oral squamous cell carcinoma (OSCC). This cancer in FA is diagnosed within the first 3-4 decades of life, and patients respond poorly to current treatments, mainly radiotherapy and chemotherapy. In addition, FA patients develop oral lesions very often that might precede malignant transformation. Research and translation of new chemopreventive and therapeutic strategies has been unsuccessful in part because disease models are scarce or do not fully reproduce the d… Show more
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